Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

1978 • 1,274 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

PATHOGENESIS OF TYPE 2 DIABETES: METABOLIC AND MOLECULAR IMPLICATIONS FOR IDENTIFYING DIABETES GENES

1997 • 701 citations

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

1997 • 549 citations

GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes

1997 • 359 citations

Insulin Signal Transduction and the IRS Proteins

1996 • 323 citations

Hexosamines and Insulin Resistance

1996 • 316 citations

Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.

1994 • 297 citations

GENETICS OF NON-INSULIN-DEPENDENT (TYPE-II) DIABETES MELLITUS

1996 • 220 citations

From receptor to transporter: insulin signalling to glucose transport

1997 • 211 citations

Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.

1997 • 144 citations

Control of Expression of Insulin Resistance and Hyperglycemia by Different Genetic Factors in Diabetic C57BL/6J Mice

1991 • 124 citations

The metabolic consequences of altered glucose transporter expression in transgenic mice

1996 • 60 citations

Overexpression of Ha-ras Selectively in Adipose Tissue of Transgenic Mice

1996 • 35 citations