Normal function of HERG K⁺ channels expressed in HEK293 cells requires basal protein kinase B activity

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

1999 • 997 citations

Properties of HERG Channels Stably Expressed in HEK 293 Cells Studied at Physiological Temperature

1998 • 716 citations

Cardiac Ionic Currents and Acute Ischemia: From Channels to Arrhythmias

1999 • 692 citations

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 • 673 citations

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

1996 • 631 citations

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.

1991 • 537 citations

The PI3K‒PDK1 connection: more than just a road to PKB

2000 • 503 citations

Molecular cloning and characterisation of a novel putative protein‐serine kinase related to the cAMP‐dependent and protein kinase C families

1991 • 485 citations

Peptide and Protein Library Screening Defines Optimal Substrate Motifs for AKT/PKB

2000 • 389 citations

herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells?

1998 • 261 citations

Rapid and slow components of delayed rectifier current in human atrial myocytes

1994 • 236 citations

HERG K+ channel, a regulator of tumor cell apoptosis and proliferation.

2002 • 215 citations

Potential Molecular Basis of Different Physiological Properties of the Transient Outward K ⁺ Current in Rabbit and Human Atrial Myocytes

1999 • 198 citations

A Novel Role for HERG K⁺ Channels: Spike‐Frequency Adaptation

1997 • 180 citations

Cyclic AMP regulates the HERG K+ channel by dual pathways

2000 • 158 citations

Akt-Dependent Potentiation of L Channels by Insulin-Like Growth Factor-1 Is Required for Neuronal Survival

1999 • 140 citations

IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1

2001 • 133 citations

Glucose‐ and arginine‐induced insulin secretion by human pancreatic β‐cells: the role of HERG K⁺channels in firing and release

2000 • 131 citations

Deletion of Protein Kinase A Phosphorylation Sites in the HERG Potassium Channel Inhibits Activation Shift by Protein Kinase A

1999 • 128 citations

Expression of Multiple Subtypes of Muscarinic Receptors and Cellular Distribution in the Human Heart

2001 • 120 citations

HERG‐ and IRK‐like Inward Rectifier Currents are Sequentially Expressed During Neuronal Development of Neural Crest Cells and their Derivatives

1997 • 114 citations

Phosphatidylinositol 3-Kinase Contributes to Cell Volume Regulation through Effects on ATP Release

1998 • 114 citations

Modulation of human erg K⁺ channel gating by activation of a G protein‐coupled receptor and protein kinase C

1998 • 90 citations

HERG Potassium Channel Activation Is Shifted by Phorbol Esters via Protein Kinase A-dependent Pathways

1998 • 90 citations

Activation of Akt during Simulated Ischemia/Reperfusion in Cardiac Myocytes

2000 • 84 citations

Type I and II models of diabetes produce different modifications of K⁺ currents in rat heart: role of insulin

1998 • 84 citations

Dysfunction of Delayed Rectifier Potassium Channels in an Inherited Cardiac Arrhythmi^a

1999 • 83 citations

Oxidative Preconditioning and Apoptosis in L-cells

2001 • 81 citations

Effects of diabetic cardiomyopathy on regional electrophysiologic characteristics of rat ventricle

2000 • 73 citations

Use-dependent 'agonist' effect of azimilide on the HERG channel.

1999 • 51 citations

Delayed afterdepolarizations and triggered activity in ventricular muscle from rats with streptozotocin-induced diabetes.

1985 • 48 citations

erg gene(s) expression during development of the nervous and muscular system of quail embryos

2000 • 37 citations

Different Subtypes of α1-Adrenoceptor Modulate Different K+ Currents via Different Signaling Pathways in Canine Ventricular Myocytes

2001 • 37 citations

Inhibition by wortmannin of M‐current in bullfrog sympathetic neurones

1995 • 29 citations