Antibiotic peptides and serine protease homologs in human polymorphonuclear leukocytes: defensins and azurocidin

Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes.

1990 • 540 citations

Crystal Structure of Defensin HNP-3, an Amphiphilic Dimer: Mechanisms of Membrane Permeabilization

1991 • 515 citations

Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.

1991 • 505 citations

Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters.

1988 • 436 citations

Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase [see comments]

1989 • 412 citations

Defensins: Endogenous antibiotic peptides of animal cells

1991 • 347 citations

Insect immunity: isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides.

1989 • 325 citations

Enteric defensins: antibiotic peptide components of intestinal host defense.

1992 • 310 citations

Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells

1989 • 293 citations

Antibiotic proteins of human polymorphonuclear leukocytes.

1989 • 273 citations

Defensins

1990 • 241 citations

The polymorphonuclear leukocyte

1978 • 235 citations

Mouse neutrophils lack defensins

1992 • 223 citations

Purification and Characterization of Human Neutrophil Peptide 4, a Novel Member of the Defensin Family

1989 • 222 citations

Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties.

1990 • 214 citations

Defensin-rich dense granules of human neutrophils

1987 • 209 citations

Cloning of the cDNA of a Human Neutrophil Bactericidal Protein

1989 • 203 citations

Cryptdins: antimicrobial defensins of the murine small intestine

1992 • 187 citations

Posttranslational processing of defensins in immature human myeloid cells

1992 • 180 citations

Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.

1992 • 163 citations

Defensin-rich dense granules of human neutrophils

1987 • 162 citations

Antibiotic proteins of human neutrophils.

1990 • 159 citations

Posttranslational processing of defensins in immature human myeloid cells

1992 • 152 citations

Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium

1990 • 146 citations

Cationic defensins arise from charge-neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity?

1992 • 128 citations

Activity of defensins from human neutrophilic granulocytes against Mycobacterium avium-Mycobacterium intracellulare

1992 • 111 citations

Solution structures of the rabbit neutrophil defensin NP-5

1988 • 105 citations

Insect immunity: expression of the two major inducible antibacterial peptides, defensin and diptericin, in Phormia terranovae.

1990 • 102 citations

Covalent structure of two novel neutrophile leucocyte‐derived proteins of porcine and human origin

1991 • 100 citations

Cloning the human lysozyme cDNA: inverted Alu repeat in the mRNA and in situ hybridization for macrophages and Paneth cells.

1988 • 99 citations

Structure of a novel human granulocyte peptide with anti-ACTH activity

1988 • 90 citations

Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase.

1990 • 89 citations

Characterization of defensin precursors in mature human neutrophils

1992 • 84 citations

Assignment of defensin gene(s) to human chromosome 8p23

1989 • 80 citations

Isolation and structure of corticostatin peptides from rabbit fetal and adult lung.

1988 • 80 citations

Amino acid sequence of CAP37, a human neutrophil granule‐derived antibacterial and monocyte‐specific chemotactic glycoprotein structurally similar to neutrophil elastase

1990 • 74 citations

A neutrophil-derived proteolytic inactive elastase homologue (hHBP) mediates reversible contraction of fibroblasts and endothelial cell monolayers and stimulates monocyte survival and thrombospondin secretion

1992 • 69 citations

Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes.

1991 • 69 citations

Human neutrophil peptide defensins induce single strand DNA breaks in target cells

1991 • 66 citations

Two-dimensional NMR studies of the antimicrobial peptide NP-5

1987 • 64 citations

Subcellular location and properties of bactericidal factors from human neutrophils.

1986 • 55 citations

Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases

1991 • 52 citations

Localization of the cryptdin locus on mouse chromosome 8

1989 • 50 citations

The isolation and identification of multiple forms of the neutrophil granule peptides from human leukemic cells.

1991 • 29 citations

Human neutrophil azurocidin synergizes with leukocyte elastase and cathepsin G in the killing of Capnocytophaga sputigena

1992 • 28 citations

Zymogen activation specificity and genomic structures of human neutrophil elastase and cathepsin G reveal a new branch of the chymotrypsinogen superfamily of serine proteinases.

1991 • 28 citations

Antibiotic proteins of human polymorphonuclear leukocytes

1989 • 24 citations

Subunit structure of high molecular weight mouse nerve growth factor

1988 • 10 citations