The Toxicokinetics and Metabolism of Polychlorinated Dibenzo-p-Dioxins (PCDDs) and Dibenzofurans (PCDFs) and Their Relevance for Toxicity

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)

1990 • 1,872 citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

Organohalogen compounds

1995 • 1,125 citations

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

1978 • 1,054 citations

Chlorodibenzo-p-dioxins and chlorodibenzofurans are trace components of fly ash and flue gas of some municipal incinerators in The Netherlands

1977 • 837 citations

Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans

1986 • 707 citations

The cytochrome P-450 system in fish, aquatic toxicology and environmental monitoring

1992 • 626 citations

GLUTATHIONE S-TRANSFERASES: GENE STRUCTURE, REGULATION, AND BIOLOGICAL FUNCTION

1989 • 624 citations

Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children

1990 • 596 citations

Cancer Mortality in Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin

1991 • 542 citations

Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.

1990 • 522 citations

The Ah Locus: Genetic Differences in Toxicity, Cancer, Mutation, and Birth Defects

1989 • 458 citations

Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action

1990 • 446 citations

Microcontaminants and reproductive impairment of the Forster's tern on Green Bay, Lake Michigan-1983

1989 • 410 citations

2,3,7,8,-Tetrachlorodibenzo-p-dioxin: segregation of toxocity with the Ah locus.

1980 • 394 citations

Organochlorine contaminants in arctic marine food chains: identification, geographical distribution and temporal trends in polar bears

1988 • 383 citations

Receptor for Albumin on the Liver Cell Surface May Mediate Uptake of Fatty Acids and Other Albumin-Bound Substances

1981 • 382 citations

Cytochrome P-450 monooxygenase systems in aquatic species: carcinogen metabolism and biomarkers for carcinogen and pollutant exposure.

1991 • 370 citations

Highly toxic coplanar PCBs: Occurrence, source, persistency and toxic implications to wildlife and humans

1987 • 347 citations

The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat

1976 • 303 citations

Potencies of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners, relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin, for producing early life stage mortality in rainbow trout (Oncorhynchus mykiss)

1991 • 295 citations

2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) and Related Compounds as Antioestrogens: Characterization and Mechanism of Action

1991 • 289 citations

Control of Cytochrome P ₁ -450 Gene Expression by Dioxin

1985 • 272 citations

Environmental fate of combustion-generated polychlorinated dioxins and furans

1984 • 271 citations

Cytochrome P-450 Monooxygenase Systems in Aquatic Species: Carcinogen Metabolism and Biomarkers for Carcinogen and Pollutant Exposure

1991 • 264 citations

Binding of a metabolite of 3,4,3′,4′-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin

1986 • 260 citations

Estimates of the half‐life of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in Vietnam veterans of operation ranch hand

1989 • 254 citations

Characterization of the H4IIE rat hepatoma cell bioassay as a tool for assessing toxic potency of planar halogenated hydrocarbons in environmental samples

1991 • 244 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase by 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Evidence for a Receptor Mutation in Genetically Non-responsive Mice

1975 • 238 citations

Dynamics of organochlorine compounds in herring gulls: III. Tissue distribution and bioaccumulation in lake ontario gulls

1989 • 233 citations

Airborne dioxins and dibenzofurans: sources and fates

1986 • 231 citations

Bioaccumulation of super‐lipophilic chemicals in fish

1984 • 231 citations

Overview on environmental fate of chlorinated dioxins and dibenzofurans. Sources, levels and isomeric pattern in various matrices

1987 • 211 citations

Pharmacokinetics of 2,3,7,8-TCDD in man

1986 • 208 citations

The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein.

1990 • 204 citations

Distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J, DBA/2J, and B6D2F1/J mice.

1983 • 175 citations

Sources and fate of PCDDs and PCDFs: An overview

1985 • 172 citations

Disposition and excretion of 2,3,7,8-tetrachlorodibenzofuran in the rat

1980 • 167 citations

PCDD and PCDF body burden from food intake in the Federal Republic of Germany

1989 • 166 citations

Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin

1988 • 163 citations

Polychlorobiphenyls (PCBs), polychlorodibenzo-p-dioxins (PCDDs) and polychlorodibenzofurans (PCDFs) in human milk, blood and adipose tissue

1987 • 160 citations

Bioaccumulation and biotransformation of polychlorinated dibenzo‐p‐dioxins and dibenzofurans in fish

1990 • 155 citations

Genetic regulation of UDP-glucuronosyltransferase induction by polycyclic aromatic compounds in mice. Co-segregation with aryl hydrocarbon (benzo(alpha)pyrene) hydroxylase induction.

1977 • 155 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin tissue distribution, excretion, and effects on clinical chemical parameters in guinea pigs

1979 • 155 citations

Mechanism of action and structure-activity relationships for the chlorinated dibenzo-p-dioxins and related compounds

1989 • 154 citations

Polychlorinated dibenzofurans (PCDFs): Effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity

1984 • 150 citations

The influence of phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin on glutathione s-transferase activity of rat liver cytosol

1978 • 148 citations

Toxicity and 7-ethoxyresorufin O-deethylase-inducing potency of coplanar polychlorinated biphenyls (PCBs) in chick embryos

1988 • 145 citations

Polychlorinated dibenzo-p-dioxins: Quantitative in vitro and in vivo structure-activity relationships

1986 • 139 citations

Polychlorinated dibenzofurans (PCDFs): Correlation between in vivo and in vitro structure-activity relationships

1985 • 139 citations

COMPARATIVE TOXICITY OF THREE HALOGENATED DIBENZOFURANS IN GUINEA PIGS, MICE, AND RHESUS MONKEYS

1979 • 138 citations

Embryotoxicity, teratogenicity, and aryl hydrocarbon hydroxylase activity in forster's terns on green bay, lake michigan

1987 • 135 citations

Cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species.

1984 • 134 citations

Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster

1980 • 131 citations

Influence of solvents and adsorbents on dermal and intestinal absorption of TCDD

1980 • 130 citations

Bioavailability of Dioxin in Soil from a 2,4,5-T Manufacturing Site

1986 • 126 citations

Toxic interaction of specific polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin: Increased incidence of cleft palate in mice

1985 • 125 citations

Polychlorinated dibenzo-p-dioxins and dibenzofurans in marine mammals in the Canadian North

1990 • 124 citations

Excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat.

1973 • 123 citations

An estimate of the maximum in vivo covalent binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to rat liver protein, ribosomal RNA, and DNA.

1979 • 123 citations

The Toxicokinetics of 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin in Mammalian Systems

1982 • 121 citations

Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: Effects on enzyme induction and immunotoxicity

1987 • 120 citations

Dioxin in Soil: Bioavailability After Ingestion by Rats and Guinea Pigs

1984 • 117 citations

Tissue Distribution, Metabolism, and Excretion of ¹⁴C‐TCDD in a TCDD‐Susceptible and a TCDD‐Resistant Rat Strain^a

1990 • 115 citations

Identification of polychlorinated dibenzofuran isomers in fly ash and PCB pyrolyses

1978 • 113 citations

Species differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and biotransformation in fish*1

1988 • 111 citations

Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse.

1977 • 109 citations

PCDD/PCDF in whole blood samples of unexposed persons

1989 • 109 citations

Immunosuppressive activities of polychlorinated biphenyls in C57BL/6N mice: Structure-activity relationships as Ah receptor agonists and partial antagonists

1990 • 109 citations

2,2′,4,4′,5,5′-Hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL6J mice

1989 • 105 citations

Dioxins and Dibenzofurans in Blood and Adipose Tissue of Agent Orange—Exposed Vietnam Veterans and Matched Controls

1988 • 104 citations

Chlorinated dibenzo-p-dioxins and chlorinated dibenzofurans in Canadian human adipose tissue

1985 • 104 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) as a potent and persistent thyroxine agonist: a mechanistic model for toxicity based on molecular reactivity.

1985 • 103 citations

Specific binding of polyhalogenated aromatic hydrocarbon inducers of cytochrome P-450d to the cytochrome and inhibition of its estradiol 2-hydroxylase activity

1987 • 101 citations

Interactive effects of estradiol and 2,3,7,8-tetrachloro-dibenzo-p-dioxin on hepatic cytochrome P-450 and mouse uterus

1986 • 101 citations

Inductive effect on hepatic enzymes and acute toxicity of individual polychlorinated dibenzofuran congeners in rats

1981 • 101 citations

Reproductive Outcomes in Colonial Fish-Eating Birds: A Biomarker for Developmental Toxicants in Great Lakes Food Chains

1991 • 101 citations

PCDD/F in an agricultural food chain Part 1: PCDD/F mass balance of a lactating cow

1990 • 100 citations

A physiological pharmacokinetic description of the tissue distribution and enzyme-inducing properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat

1990 • 99 citations

Distribution and excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin in congenic strains of mice which differ at the Ah locus.

1986 • 98 citations

Dose-response immunotoxicities of commercial polychlorinated biphenyls (PCBs) and their interaction with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1989 • 96 citations

Presence of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in fish-eating birds and fish from The Netherlands

1987 • 95 citations

Tissue distribution, excretion and biological effects of in rats

1975 • 94 citations

Polychlorodibenzo-p-dioxin and pentachlorophenol residues in milk and blood of cows fed technical pentachlorophenol

1979 • 93 citations

PCDD and PCDF levels in human milk - dependence on the period of lactation

1989 • 92 citations

Aroclor 1254 as an antagonist of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin

1987 • 91 citations

Toxic significance of planar aromatic compounds in Baltic ecosystem — New studies on extremely toxic coplanar PCBs

1989 • 89 citations

Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin

1989 • 89 citations

Toxicity and fetotoxicity of TCDD, TCDF and PCB isomers in rhesus macaques (Macaca mulatta).

1985 • 88 citations

A physiologically based pharmacokinetic model for 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice

1988 • 86 citations

Comparative antiestrogenic activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in the female rat

1988 • 86 citations

Differential toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J mice congenic at the Ah locus

1990 • 85 citations

Tissue distribution and excretion of tritiated tetrachlorodibenzo-p-dioxin in non-human primates and rats

1976 • 85 citations

Identification of polychlorinated dibenzofurans (PCDFs) retained in patients with Yusho

1979 • 85 citations

Bioavailability of soil-bound TCDD: Dermal bioavailability in the rat

1988 • 84 citations

Hepatic Ah-receptor levels and the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on hepatic microsomal monooxygenase activities in a TCDD-susceptible and -resistant rat strain

1988 • 84 citations

Determination of polychlorinated dibenzofurans in tissues of patients with ‘Yusho’

1977 • 83 citations

Control of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Multiple dioxin-responsive domains 5'-ward of the cytochrome P1-450 gene.

1986 • 83 citations

Retention and excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin by rats

1975 • 83 citations

Bioconcentration potential of organic environmental chemicals in humans

1986 • 82 citations

Physiological model for the pharmacokinetics of 2,3,7,8-tetrachlorodibenzofuran in several species

1983 • 81 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin Levels in Adipose Tissue of Exposed and Control Persons in Missouri

1986 • 79 citations

Bioconcentration of PCDDs by fish: Effects of molecular structure and water chemistry

1985 • 79 citations

Han/Wistar Rats are Exceptionally Resistant to TCDD. I

1987 • 78 citations

Metabolismin vivoof 3,4,3′,4′-tetrachlorobiphenyl and toxicological assessment of the metabolites in rats

1987 • 75 citations

Transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) via placenta and milk, and postnatal toxicity in the mouse

1986 • 75 citations

Transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to the mouse embryo and fetus

1981 • 74 citations

Molecular interactions of toxic chlorinated dibenzo-p-dioxins and dibenzofurans with thyroxine binding prealbumin

1985 • 74 citations

Mono-ortho-chlorinated chlorobiphenyls: Toxicity and induction of 7-ethoxyresorufinO-deethylase (EROD) activity in chick embryos

1990 • 74 citations

Dioxin contamination and growth and development in great blue heron embryos

1991 • 73 citations

Disposition of octachlorodibenzo-p-dioxin (OCDD) in male rats*1

1988 • 73 citations

Comparison of polychlorinated dibenzodioxin levels with hepatic mixed‐function oxidase induction in great blue herons

1990 • 73 citations

Physiological implications of estrogen receptor modulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin

1988 • 72 citations

Chronic dietary intake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at 5 or 25 parts per trillion in the monkey: TCDD kinetics and dose-effect estimate of reproductive toxicity

1989 • 72 citations

Synergistic interactions of 2, 3, 7, 8-TCDD and 2, 2′, 4, 4′, 5, 5′-hexachlorobiphenyl in C57BL/6J and DBA/2J mice: Role of the Ah receptor

1987 • 71 citations

Yusho, with reference to Yu-Cheng

1989 • 70 citations

Morphologic lesions and acute toxicity in rainbow trout(Salmo Gairdneri)treated with 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin

1988 • 70 citations

Postnatal stimulation of hepatic microsomal enzymes following administration of TCDD to pregnant rats

1975 • 70 citations

Levels and patterns of PCDD and PCDF contamination in fish, crabs, and lobsters from Newark Bay and the New York Bight

1991 • 70 citations

Polychlorinated biphenyls and related compound interactions with specific binding sites for thyroxine in rat liver nuclear extracts

1987 • 69 citations

Mechanism of action of aryl hydrocarbon receptor antagonists: Inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression

1992 • 69 citations

Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rainbow trout*1

1986 • 68 citations

Dietary accumulation of four chlorinated dioxin congeners by rainbow trout and fathead minnows

1988 • 68 citations

Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in guinea pigs

1986 • 68 citations

Levels, trends and patterns of PCDDs and PCDFs in Scandinavian environmental samples

1989 • 68 citations

A Physiologically Based Pharmacokinetic Model for 2,3,7,8-Tetrabromodibenzo-p-dioxin (TBDD) in the Rat: Tissue Distribution and CYP1A Induction

1993 • 67 citations

Determination of polychlorinated dibenzofuran isomers retained in patients with Yusho

1978 • 65 citations

Organ-specific effects of long term feeding of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 1,2,3,7,8-pentachlorodibenzo-p-dioxin on I-compounds in hepatic and renal DNA of female Sprague-Dawley rats

1988 • 65 citations

Polychlorinated biphenyls, dibenzofurans and quaterphenyls in toxic rice-bran oil and in the blood and tissues of patients with PCB poisoning (Yu-Cheng) in Taiwan.

1985 • 64 citations

In vitro AHH induction by polychlorinated biphenyl and dibenzofuran mixtures: Additive effects

1985 • 64 citations

Polychlorinated dibenzofurans and polychlorinated dibenzo‐p‐dioxins in great lakes fish: A baseline and interlake comparison

1989 • 63 citations

Ingestion of soil contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic enzyme activities in rats

1986 • 63 citations

Assessment of relative toxicity of chlorinated dibenzo- -dioxins, dibenzofurans, and biphenyls in Lake Ontario salmonids to mammalian systems using toxic equivalent factors (TEP)

1989 • 63 citations

Teratogenic effects of polychlorinated dibenzofurans in combination in mice

1987 • 61 citations

Distribution and excretion of 2,3,7,8-tetrachlorodibenzofuran in C57BL/6J and DBA/2J mice

1981 • 61 citations

Stimulation of in vivo hepatic uptake and in vitro hepatic binding of [125I]2-lodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonist for the Ah receptor.

1989 • 60 citations

Multifunctional receptor model for dioxin and related compound toxic action: possible thyroid hormone-responsive effector-linked site.

1989 • 59 citations

Effect of microsomal enzyme inducers on the soluble enzymes of hepatic phase II biotransformation

1982 • 59 citations

Partitioning of in vivo bound PCDDs/PCDFs among various compartments in whole blood

1989 • 59 citations

Dietary accumulation and sustained hepatic mixed function oxidase enzyme induction by 2,3,4,7,8-pentachlorodibenzofuran in rainbow trout

1990 • 59 citations

Dioxin-like effects observed in male rats following exposure to octachlorodibenzo-p-dioxin (OCDD) during a 13-week study*1

1988 • 58 citations

Background levels in humans

1989 • 58 citations

Levels of PCDFs and PCDDs in samples of human origin and food in the Federal Republic of Germany

1987 • 57 citations

6-methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice

1989 • 57 citations

Toxicokinetics of eight 13C-labelled polychlorinated dibenzo-p-dioxins and - furans in lactating cows

1991 • 57 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and 2,3,7,8-tetrachlorodibenzofuran (TCDF) in pregnant C57BL/6N mice: distribution to the embryo and excretion

1985 • 56 citations

Toxicity and Bioconcentration of 2,3,7,8-TCDD to fathead minnows ( )

1986 • 56 citations

High affinity of 2,3,4,7,8-pentachlorodibenzofuran to cytochrome P-450 in the hepatic microsomes of rats

1986 • 56 citations

Comparative toxicity and biologic activity of chlorinated dibenzo-p-dioxins and furans relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

1985 • 56 citations

Correlation between acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and total body fat content in mammals

1990 • 56 citations

Organ specific induction of drug metabolizing enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat

1978 • 56 citations

Disposition of 2,3,7,8-tetrabromodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat: Biliary excretion and induction of cytochromes CYP1A1 and CYP1A2

1991 • 55 citations

Assessment of the EROD inducing potency of eleven 2,3,7,8- substituted PCDD/Fs and three coplanar PCBs in the chick embryo

1992 • 55 citations

Human body burden of polychlorinated dibenzofurans associated with toxicity based on the yusho and yucheng incidents*1

1990 • 55 citations

The presence of PCDDs and PCDFs in human breast milk from the Netherlands

1986 • 55 citations

Biological degradation of TCDD in rats

1979 • 54 citations

Determination of polychlorinated dibenzodioxins and dibenzofurans in human milk

1986 • 54 citations

Disposition and excretion of 2,3,4,7,8-pentachlorodibenzofuran in the rat*1

1987 • 54 citations

Limited PCB antagonism of TCDD-induced malformations in mice

1992 • 53 citations

Subchronic toxicity of some chlorinated dibenzofurans (PCDFs) and a mixture of PCDFs and chlorinated dibenzodioxins (PCDDs) in rats

1988 • 53 citations

Pharmacokinetics of [125I]-2-lodo-3,7,8-trichlorodibenzo-p-dioxin in mice: Analysis with a physiological modeling approach

1990 • 52 citations

TCDD (2, 3, 7, 8‐tetrachlorodibenzo‐p‐dioxin) is a tight binding inhibitor of cytochrome p‐450D

1989 • 52 citations

Accumulation of polychlorinated dibenzofurans in the livers of monkeys and rats

1980 • 51 citations

Teratogenicity of three polychlorinated dibenzofurans in C57BL/6N mice*1

1987 • 50 citations

Effects of TCDD-estradiol interactions in three strains of mice

1988 • 50 citations

Identification of metabolites of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) formed on incubation with isolated rat hepatocytes

1982 • 50 citations

Chemical and physical properties, analytical methods, sources and environmental levels of halogenated dibenzodioxins and dibenzofurans

1989 • 50 citations

2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin toxicity in yellow perch(Perca flavescens)

1988 • 49 citations

Rat metabolism of polychlorinated dibenzo-p-dioxins

1978 • 49 citations

Hepatic metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat and guinea pig*1

1985 • 49 citations

Polychlorinated Biphenyls, Dibenzofurans and Quaterphenyls in Toxic Rice-Bran Oil and in the Blood and Tissues of Patients with PCB Poisoning (Yu-Cheng) in Taiwan

1985 • 49 citations

Bioconcentration and disposition of 1,3,6,8‐tetrachlorodibenzo‐p‐dioxin and octachlorodibenzo‐p‐dioxin by rainbow trout and fathead minnows

1986 • 49 citations

Biotransformation, bioaccumulation and lethality of 2,8-dichlorodibenzo-p-dioxin: a proposal to explain the biotic fate and toxicity of PCDD's and PCDF's

1988 • 48 citations

Polychlorinated dibenzodioxins and dibenzofurans in human milk samples from Western Germany

1987 • 48 citations

Dibenzofurans a greater global pollutant than dioxins ?

1987 • 47 citations

Background human exposure to 2,3,7,8-TCDD

1985 • 47 citations

2,3,7,8-Tetrachlorodibenzofuran tissue distribution and excretion in guinea pigs

1981 • 47 citations

Synthesis, biologic and toxic effects of the major 2,3,7,8-tetrachlorodibenzo-p-dioxin metabolites in the rat

1986 • 46 citations

Relative Liver Tumour Promoting Activity and Toxicity of some Polychlorinated Dibeiizo‐p‐dioxin‐ and Dibenzofuran‐Congeners in Female Sprague‐Dawley Rats

1991 • 46 citations

Uptake and specific binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the olfactory mucosa of mice and rats.

1987 • 45 citations

Sources and emissions of PCDD/PCDF

1989 • 45 citations

Uptake and selective retention in rats of orally administered chlorinated dioxins and dibenzofurans from fly-ash and fly-ash extract

1983 • 44 citations

The in vivo biotransformation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat

1982 • 43 citations

Assessing the elimination of 2,3,7,8-TCDD from humans with a physiologically based pharmacokinetic model

1988 • 43 citations

Transfer of Polychiorinated Dibenzo-p-dioxins and Dibenzofurans to Fetal and Neonatal Rats

1987 • 42 citations

Partitioning of 2,3,7,8-chlorinated dibenzo-p-dioxins and dibenzofurans between adipose tissue and plasma lipid of 20 Massachusetts Vietnam veterans

1990 • 42 citations

MECHANISMS IN THE THERMAL FORMATION OF CHLORINATED COMPOUNDS INCLUDING POLYCHLORINATED DIBENZO-p-DIOXINS

1982 • 41 citations

Comparison of the polychlorinated dibenzo-p-dioxin and dibenzofuran in human tissue and human liver

1990 • 41 citations

P450 Genes: Evolution, Regulation, and Relationship To Human Cancer and Pharmacogenetics

1986 • 41 citations

Comparative toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in four (sub)strains of adult male rats

1985 • 40 citations

Effects of substituents on the cytosolic receptor-binding avidities and aryl hydrocarbon hydroxylase induction potencies of 7-substituted 2,3-dichlorodibenzo-p-dioxins. A quantitative structure-activity relationship analysis.

1985 • 40 citations

Persistence of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) in hepatic and adipose tissue of marmoset monkeys

1990 • 39 citations

Toxicity of 2,3,7,8-TCDD and short-term bioaccumulation by earthworms (oligochaeta)

1984 • 39 citations

Biotransformation and tissue distribution of 1,2,3,7-tetrachlorodibenzo-p-dioxin, 1,2,3,4,7-pentachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran in rainbow trout

1990 • 39 citations

Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and three polychlorinated dibenzofurans

1989 • 39 citations

In situ protein-DNA interactions at a dioxin-responsive enhancer associated with the cytochrome P1-450 gene.

1987 • 38 citations

Studies on the mechanism of absorption and distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat.

1986 • 38 citations

Bioavailability of PCDDs and PCDFs from bottom sediments and some associated biological effects in the carp (Cyprinus carpio)

1989 • 38 citations

Polychlorinated dibenzofurans (PCDFs)

1985 • 37 citations

Absorption and tissue distribution of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) in the rat

1989 • 37 citations

Age-related changes in dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran*1

1990 • 37 citations

2,3,7,8-tetrachlorodibenzo-p-dioxin and related dioxins and furans in snapping turtle () tissues from the upper St. Lawrence River

1986 • 37 citations

Transfer of polychlorinated dibenzo-p-dioxins and dibenzofurans to fetal and neonatal rats

1987 • 36 citations

Isomer dependent bioavailability of polychlorinated dibenzo-p-dioxins and dibenzofurans from municipal incinerator fly ash to carp

1987 • 36 citations

Uptake and depuration studies of PCDDs and PCDFs in freshwater fish

1986 • 36 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on I-compounds in hepatic DNA of sprague-dawley rats: Sex-specific effects and structure-activity relationships

1990 • 36 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin pretreatment of female mice altered tissue distribution but not hepatic metabolism of a subsequent dose

1990 • 35 citations

Quantitative structure-activity relationships: analysis of interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2-substituted analogues with rat, mouse, guinea pig, and hamster cytosolic receptor.

1987 • 35 citations

Biological half‐lives of chlorinated dibenzo‐p‐dioxins and dibenzofurans in rainbow trout (Salmo gairdneri)

1986 • 35 citations

Concentrations of PCDD and PCDF in human fat and liver samples

1989 • 35 citations

Fate of 2,3,7,8-tetrachlorodibenzofuran in the monkey

1981 • 35 citations

The control of cytochrome P-450 gene expression by dioxin

1989 • 35 citations

The metabolism of some pentachlorodibenzofurans in the rat

1987 • 34 citations

Halogenated aromatic compounds in automotive emissions from leaded gasoline additives

1986 • 34 citations

Tissue distribution and excretion of octachlorodibenzo-p-dioxin in the rat

1975 • 34 citations

Levels of PCDDS and PCDFS in human tissues and various foodstuffs in Japan

1987 • 33 citations

Toxicity and disposition of 2,3,4,7,8-pentachlorodibenzofuran (4PeCDF) in the Rhesus monkey (Macaca mulatta)

1988 • 33 citations

Bioavailability of soil-bound TCDD: Oral bioavailability in the rat

1988 • 33 citations

Bioavailability of 2,3,7,8-tetrachlorodibenzo-p-dioxin from municipal incinerator fly ash to freshwater fish

1985 • 33 citations

Influence of biotransformation on the accumulation of PCDDs from fly-ash in fish

1989 • 33 citations

2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin receptors regulate transcription of the cytochrome P₁‐450 gene

1987 • 33 citations

Comparative study of 3,4,3′,4′‐tetrachlorobiphenyl in male and female rats and female monkeys

1981 • 33 citations

Transfer of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) via placenta and through milk in a marmoset monkey

1990 • 33 citations

Clearance and tissue distribution of polychlorinated dibenzofurans in mice

1977 • 32 citations

6-substituted-1,3,8-trichlorodibenzofurans as 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists in the rat: structure activity relationships

1989 • 32 citations

Polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran levels in human breast milk from Vietnam compared with cow's milk and human breast milk from the North American continent

1987 • 32 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch*1

1986 • 32 citations

Effect of water chlorination upon levels of some polynuclear aromatic hydrocarbons in water

1976 • 31 citations

Studies on the metabolic fate of [14C]2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the mouse

1984 • 31 citations

PCDD and PCDF concentrations in different organs from infants

1990 • 31 citations

The Distribution of [14C]-2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and its Effect on the Vitamin A Content in Parenchymal and Stellate Cells of Rat Liver

1989 • 31 citations

Relative distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin human hepatic and adipose tissues

1990 • 31 citations

Statistical evaluations reflecting the skewness in the distribution of TCDD levels in human adipose tissue

1987 • 31 citations

Han/Wistar Rats Are Exceptionally Resistant to TCDD. II.

1987 • 30 citations

Determination of [3H]-2,3,7,8-tetrachlorodibenzo-p-dioxin in human feces to ascertain its relative metabolism in man

1990 • 30 citations

Effects on fish and wildlife populations

1989 • 30 citations

Acute and chronic toxicity and carcinogenesis in animals

1989 • 30 citations

Changes in hamster hepatic cytochrome p-450, ethoxycoumarin o-deethylase, and reduced nad(p):menadione oxidoreductase following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1986 • 30 citations

Human tissue levels of PCDDs and PCDFs from a fatal pentachlorophenol poisoning

1987 • 29 citations

Substituted polychlorinated dibenzofuran receptor binding affinites and aryl hydrocarbon hydroxylase induction potencies — A QSAR analysis

1986 • 29 citations

Pharmacok inetics and metabolism of 1,2,3,7,8-pentachlorodibenzo-p-dioxin in the rat

1986 • 29 citations

Effects of TCDD on vitamin A status and liver microsomal enzyme activities in a TCDD-susceptible and a TCDD-resistant rat strain

1990 • 29 citations

Acute oral toxicity of tcdd-metabolites in male guinea pigs

1982 • 28 citations

Effect of thyroid hormones on liver microsomal enzyme induction in rats exposed to 2,3,7,8,-tetra-chlorodibenzo-p-dioxin

1985 • 28 citations

The toxicological significance of 2, 3, 7, 8‐tetrachlorodibenzo‐p‐dioxin and related compounds in human adipose tissue

1987 • 28 citations

The effect of strong alkali on the determination of polychlorinated dibenzofurans (PCDFs) and polychlorinated dibenzo-p-dioxins (PCDDs)

1989 • 28 citations

The metabolism of 2,3,7,8-tetrachlorodibenzofuran in the rat

1984 • 27 citations

Propagation of error and bias in half-life estimates based on two measurements

1989 • 27 citations

Transfer of polychlorinated dibenzofurans to the foetuses and offspring of mice

1980 • 27 citations

The Influence of Soil Particle Adsorption on 2,3,7,8-Tetrachlorodibenzo-p-dioxin Biological Uptake in the Rabbit

1984 • 27 citations

Nonadditive interactive effects of polychlorinated biphenyl congeners in rats: role of the 2,3,7,8-tetraehlorodibenzo-p-dioxin receptor

1987 • 27 citations

The metabolism of some chlorinated dibenzofurans by rats

1981 • 27 citations

Mechanisms of the biological effects of PCBs, polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in experimental animals.

1985 • 27 citations

Subchronic toxicity of some chlorinated dibenzofurans in rats

1989 • 26 citations

Disposition of 1,2,3,7,8-pentachlorodibenzofuran in the rat

1988 • 26 citations

Uptake and elimination of PCDD/PCDF congeners by fish after aqueous exposure to a fly-ash extract from a monicipal incimerator

1986 • 26 citations

Bioavailability of grain and soil-borne tritiated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered to lactating Holstein cows

1989 • 26 citations

Distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human whole blood and its association with, and extractability from, lipoproteins

1988 • 26 citations

Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners: Mechanistic studies

1990 • 25 citations

Reproductive and developmental toxicity in animals

1989 • 24 citations

Inductive potency of TCDD, TBDD and three 2,3,7,8-mixed-halogenated dioxins in liver microsomes of male rats. Enzyme kinetic considerations

1991 • 24 citations

Interactions of 2,2′,4,4′,5,5′-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin in a subchronic feeding study in the rat

1992 • 24 citations

Interactive effects of PCDD's, PCDF's and PCB's as assessed by the E.L.S.-bioassay

1989 • 23 citations

High accumulation of 2,3,4,7,8-pentachlorodibenzofuran to hepatic microsomes of rats.

1984 • 23 citations

Selective accumulation of chlorobenzenes, polychlorinated dibenzofurans and 2,3,7,8-TCDD in wildlife of the Volgermeerpolder, Amsterdam, Holland

1986 • 23 citations

Toxicity of 3,4,5,3′,4′,5′-hexabrominated biphenyl and 3,4,3′,4′-tetrabrominated biphenyl

1985 • 23 citations

Absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) after low dose dermal exposure

1991 • 23 citations

Biologic and toxic effects of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in the guinea pig

1988 • 22 citations

Subchronic toxicity of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) in rats

1988 • 22 citations

The Role of Receptors in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Toxicity

1985 • 22 citations

Stimulating effect of activated charcoal beads on fecal excretion of 2,3,4,7,8-pentachlorodibenzofuran in rats

1986 • 22 citations

Disposition and excretion of intravenous 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) in rats

1991 • 22 citations

Decrease over a six year period of dioxin and dibenzofuran tissue levels in a single patient following exposure

1990 • 21 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin or 2,2′,4,4′,5,5′-hexachlorobiphenyl on vitamin K-dependent blood coagulation in female germfree WAG/Rij-rats

1992 • 21 citations

Yu-Cheng

1989 • 21 citations

Relationship between the murine Ah phenotype and the hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1987 • 21 citations

Persistence of some polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans of pentachlorophenol in human adipose tissue.

1984 • 20 citations

Comparative studies on absorption and distribution in the liver and adipose tissue of PCDDs and PCDFs in rats and marmoset monkeys

1989 • 20 citations

Bioavailability and Cytochrome P-450 Induction from 2,3,7,8 Tieirachlorodibenzo-P-Dioxin Contaminated Soils from Times Beach, Missouri, and Newark, New Jersey

1988 • 19 citations

Selective retention of toxic polychlorinated dibenzo-p-dioxins and dibenzofurans in the liver of the rat after intravenous administration of a mixture

1989 • 19 citations

Qualitative and quantitative differences in the induction and inhibition of hepatica benzo[a]pyrene metabolism in the rat and hamster

1988 • 19 citations

The binding of 2,3,7,8-tetrachlorodibenzodioxin to plasma lipoproteins may delay toxicity in experimental hyperlipidemia

1983 • 19 citations

Dioxins and related aromatic chloroethers in Baltic wildlife

1987 • 18 citations

The metabolism of selected PCDFs in the rat

1989 • 18 citations

Inducing Potency of Aryl Hydrocarbon Hydroxylase Activity in Human Lymphoblastoid Cells and Mice by Polychlorinated Dibenzofuran Congeners

1985 • 18 citations

The Seveso accident: medical survey of a TCDD exposure

1989 • 18 citations

Elimination of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) in rat faeces

1989 • 18 citations

Enhanced faecal excretion of 2,3,4,7,8-pentachlorodibenzofuran in rats by a long-term treatment with activated charcoal beads

1988 • 18 citations

Transfer of various PCDDs and PCDFs via placenta and mother's milk to marmoset offspring

1990 • 18 citations

Bio-availability of PCDDs and PCDFs on fly ash after semi-chronic oral ingestion by the rat

1986 • 17 citations

Disposition and elimination of three polychlorinated dibenzofurans in the liver of the rat.

1989 • 17 citations

Nad(P)H:quinone oxidoreductase (DT-diaphorase) in chick embryo liver

1990 • 17 citations

STUDIES ON MICROBIAL METABOLISM OF TCDD UNDER LABORATORY CONDITIONS

1982 • 16 citations

An analytical assessment of the bioavailability of dioxin contaminated soils to animals

1989 • 16 citations

Effect of monooxygenase inducers and inhibitors on the hepatic metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat and hamster.

1988 • 16 citations

Bioavailability of PCDDs and PCDFs on fly ash after semi-chronic oral ingestion by guinea pig and syrian golden hamster

1986 • 16 citations

Planar chlorinated hydrocarbons (PCHs) in colonial fish-eating waterbird eggs from the Great Lakes

1989 • 15 citations

Prevention of TCDD toxicity in laboratory rodents by addition of charcoal or cholic acids to chow

1984 • 15 citations

Determination of PCDD/PCDF in whole blood from persons involved in fire incidents

1990 • 15 citations

Retention of PCDDS and PCDFS in the liver of the rat and hamster after oral administration of a municipal incinerator fly ash extract

1986 • 15 citations

Fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin metabolites from dogs in rats

1982 • 15 citations

Intracellular lipoproteins as carriers for 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo(a)pyrene in rat and mouse liver

1989 • 15 citations

TCDD and chlorinated dibenzofurans in top soil and biological samples from a contaminated refuse dump

1985 • 15 citations

Absorption of TCDD following parenteral application in rats using various vehicles

1989 • 14 citations

Factors affecting the induction of DT-diaphorase by 2,3,7,8-tetrachlorodibenzo-p-dioxin

1978 • 14 citations

Effect of Polychlorinated Dibenzofuran on the Retention of Polychlorinated Biphenyl Isomers in the Liver and Adipose Tissue of Mice

1982 • 14 citations

A method performance evaluation and lessons learned after analyzing more than 5,000 human adipose tissue, serum, and breast milk samples for polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs)

1990 • 14 citations

Selective retention of PCDDs and PCDFs in mammals: A multiple cause problem

1989 • 14 citations

The structure-dependent effects of heptachlorodibenzofuran isomers in male C57BL/6 mice: Immunotoxicity and monooxygenase enzyme induction

1990 • 14 citations

A long-term study of ecosystem contamination with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1987 • 14 citations

Theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins and dibenzofuran to human plasma prealbumin

1986 • 14 citations

Uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin from plasma lipoproteins by cultured human fibroblasts

1986 • 14 citations

Localized contamination with 2,3,7,8-tetrachlorodibenzo-p-dioxin: the Missouri episode

1989 • 13 citations

Bioaccumulation of PCDD's and OCDF in fish after aqueous and dietary exposure

1986 • 13 citations

Influence of phenobarbital and TCDD on the hepatic metabolism of TCDD in the dog

1985 • 13 citations

Disposition and elimination of three polychlorinated dibenzofurans in the liver of the rat

1989 • 13 citations

Enzyme induction and alterations in thyroid hormone, vitamin A and K levels by TCDD in neonatal and maternal rats

1990 • 13 citations

Analysis of 2,3,7,8-TCDD tumor promotion activity and its relationship to cancer

1989 • 12 citations

The influence of aging on intestinal absorption of TCDD in rats

1987 • 12 citations

Toxicity and distribution of 2,3,7,8‐tetrachlorodibenzofuran in male guinea pigs

1983 • 12 citations

Hepatic aryl hydrocarbon hydroxylase and cytochrome P450 induction following the transpulmonary absorption of TCDD from intratracheally instilled particles

1990 • 12 citations

PCDDs and PCDFs carried to the human body from the diet

1987 • 12 citations

Subchronic effects of exposure to octachlorodibenzodioxin (OCDD)

1989 • 11 citations

3,4,3',4'-Tetrachlorobiphenyl-Induced Effects in the Rat Liver. I. Serum and Hepatic Retinoid Reduction and Morphologic Changes

1989 • 11 citations

Specific congener profiles of polychlorinated dibenzo-p-dioxins and dibenzofurans in blue mussel in Osaka Bay in Japan: Aqueous solubilities of PCDDs and PCDFs

1989 • 11 citations

Identification of the biliary metabolites of 2,3,7,8-tetrachlorodibenzofuran in the rat

1990 • 11 citations

Effects of vitamin A and/or thyroidectomy on liver microsomal enzymes and their induction in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats

1987 • 10 citations

Distribution of PCDDs and PCDFs in rat tissues following various routes of administration

1989 • 10 citations

Induction of hepatic monooxygenases in female rats and offspring in correlation with TCDD tissue concentrations after single treatment during pregnancy

1990 • 10 citations

Elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxine in goat milk

1981 • 10 citations

Prediction of hydroxylated metabolites in polychlorodibenzo-p-dioxins and polychlorodibenzofurans by Hückel molecular orbital calculations

1983 • 10 citations

Vehicle dependent bioavailability of polychlorinated dibenzo-p-dioxins (PCDDs) and -dibenzofurans (PCDFs) in the rat

1987 • 10 citations

Hepatic retention of PCDDs and PCDFs in C57BI/6 and DBA/2 Mice

1989 • 10 citations

Studies on the retention of individual polychlorinated dibenzofurans (PCDFs) in the liver of different species

1990 • 10 citations

Regulation of Cytochrome P₁-450 Gene Expression in Mouse Hepatoma Cells by 2,3,7,8-Tetrachloflodibenzo-p-Dioxin

1989 • 10 citations

A survey of 2,3,7,8 tetrachlorodibenzo-p-dioxin residues in selected animal species from Times Beach, Missouri

1989 • 10 citations

Autoradiography of 2,3,7,8-tetrachloro [14C]-dibenzo-p-dioxin (TCDD): Accumulation in the nasal mucosa

1983 • 9 citations

Controlled exposure of female rhesus monkeys to 2,3,7,8-TCDD: Concentrations of TCDD in fat of offspring, and its decline over time

1990 • 9 citations

Estimating bioconcentration factors and half-lives in humans using physiologically based pharmacokinetic modelling: 2,3,7,8-TCDD

1991 • 8 citations

Metabolism of 2,8-dichlorodibenzofuran in rats

1989 • 8 citations

DIOXINS AND FURANS IN THE ENVIRONMENT: EVALUATING TOXICOLOGICAL RISK FROM DIFFERENT SOURCES BY MULTI-CRITERIA ANALYSIS.

1985 • 8 citations

The dioxin receptor: Characterization of its DNA-binding properties

1988 • 8 citations

3,4,3,4'-Tetrachlorobiphenyl-Induced Effects in the Rat Liver. II. Electron Microscopic Autoradiographic Localization of H-TCB

1989 • 8 citations

Chlorinated compounds in tissues of chickens raised on pentachlorophenol‐contaminated litter

1984 • 7 citations

PCB capacitor/transformer accidents

1989 • 7 citations

Nonaccumulation of chlorinated dioxins and furans by goldfish exposed to contaminated sediment and flyash

1986 • 7 citations

Chemically induced hepatic cytosol from the Sprague—Dawley rat: evidence for specific binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to components kinetically distinct from the Ah receptor

1990 • 7 citations

TRANSFER OF 2,3,7,8-TETRACHLORO-DIBENZO-p-DIOXIN (TCDD) TO THE MOUSE EMBRYO, FETUS AND NEONATE

1982 • 7 citations

Biological activity and tissue concentrations of TCDD and OCDD in rats after s.c. application alone and in combination

1990 • 7 citations

Storage and elimination of 2,3,7,8-tetrabromodibenzo-p-dioxin in liver and adipose tissue of the rat

1990 • 6 citations

Investigation of American lobster,Homarus americanus, for the presence of chlorinated dibenzo-p-dioxins and dibenzofurans

1987 • 6 citations

Metabolism of polychlorinated dibenzofurans (PCDFs) in rats

1990 • 5 citations

Polychlorinated dibenzofuran (PCDF) congeners in the tissues of patients with Yusho and normal Japanese

1987 • 5 citations

Studies on the bioavailability of 2,3,7,8-TCDD from municipal incinerator flyash to freshwater fish

1985 • 5 citations

Effects of combinations of PCDDs/PCDFs given to Sprague-Dawley rats

1989 • 5 citations

Toxicokinetic interactions in the liver of the C57/BL/6J mouse after administration of a single oral dose of a binary mixture of some PCBs

1992 • 5 citations

Disposition and metabolism of 2,3,7,8-tetrachlorodibenzofuran (TCDF) in rainbow trout

1992 • 5 citations

Comparative bioavailability of the 2,3,7,8 chlorine substituted dioxins and furans from flue ash and flue ash extract in rat liver

1992 • 4 citations

Toxicity and biochemical protencies of polychlorinated biphenyl congeners relative to 2,3,7,8-tetrachlori-dibenzo-p-dioxin in three months feeding studies in the rat.

1992 • 4 citations

Comparison of cleft palate frequency and TCDD concentration in mice at different stages of development

1990 • 4 citations

Comparative toxicologic study of 2,3,4,7,8-pentachlorodibenzofuran in Ah responsive and nonresponsive strains of mice

1990 • 4 citations

A survey of 2,3,7,8-TCDD residues in fish from the Great Lakes and selected Michigan rivers

1985 • 4 citations

Unique features of subcellular distribution of 2,3,4,7,8-pentachlorodibenzofuran in rat liver

1987 • 4 citations

Species comparison of steroid UDP-glucuronyl transferase: Correlation to TCDD sensitivity

1989 • 3 citations

The effects of recptor modulators on the AHH induction activity of 2,3,7,8-TCDD in C57BL/6 and DBA/2 mice

1987 • 3 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin elimination in the rat: First order or zero order?

1976 • 3 citations

Reexamination of the dose-response relationship for induction of the hepatic monooxygenase system by 2,3,7,8-TCDD

1989 • 3 citations

[Acute toxicity, inductive effects of liver enzymes and distribution in the liver of 1,2,3,7,8-pentachlorodibenzo-p-dioxin in rats].

1991 • 3 citations

The relative induction of mixed‐function oxidase specific activity to CH and CC1 bond strengths in polychlorinated derivatives of dibenzo‐p‐dioxin (PCDDs)

1986 • 3 citations

Metabolism of 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD) in isolated hepatocytes from guinea pigs and rats

1985 • 3 citations

TCDD and 2,3,4,7,8-PeCDF temporal interaction of vitamin A depletion and hepatic enzyme-inducton in the rat

1990 • 2 citations

Effect of TCDD and comparable inducers upon synthesis of monooxygenase forms P-450c and P-450d in rats

1989 • 2 citations

Localization of TCDD in hairless mouse skin

1986 • 2 citations

The induction and subsequent return to basal activity of liver enzyme activity in male C5/BL/6 mice after a single oral dose of 1,2,3,7,8-PnCDD or 1,2,3,6,7,8-HxCDD

1990 • 1 citations

Einige Aspekte über höher chlorierte Dibenzo-p-Dioxine und Furane

1989 • 1 citations

Effects of chlorinated dibenzofuran and dioxin on concentration and pattern of chlorobiphenyls and activity of benzo(a)pyrene hydroxylation in mice.

1985 • 1 citations

Chlorodibenzo-p-dioxins in the feral pigeon

1987 • 1 citations