Pharmacokinetics of [125I]-2-lodo-3,7,8-trichlorodibenzo-p-dioxin in mice: Analysis with a physiological modeling approach

TheAhLocus: Genetic Regulation of the Metabolism of Carcinogens, Drugs, and Other Environmental Chemicals by Cytochrome P-450-Mediated Monooxygenase

1979 • 317 citations

The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat

1976 • 303 citations

Genetic Regulation of Aryl Hydrocarbon Hydroxylase Induction

1972 • 247 citations

Health implications of 2,3,7,8‐tetrachloro‐dibenzodioxin (TCDD) contamination of residential soil

1984 • 228 citations

Distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J, DBA/2J, and B6D2F1/J mice.

1983 • 175 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin tissue distribution, excretion, and effects on clinical chemical parameters in guinea pigs

1979 • 155 citations

Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster

1980 • 131 citations

Dioxin in Soil: Bioavailability After Ingestion by Rats and Guinea Pigs

1984 • 117 citations

Cytosolic and Nuclear Binding of 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin to the AhReceptor in Extra‐Hepatic Tissues of Rats and Mice

1982 • 103 citations

Specific binding of polyhalogenated aromatic hydrocarbon inducers of cytochrome P-450d to the cytochrome and inhibition of its estradiol 2-hydroxylase activity

1987 • 101 citations

A physiological pharmacokinetic description of the tissue distribution and enzyme-inducing properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat

1990 • 99 citations

Kinetic and equilibrium studies of Ah receptor-ligand binding: use of [125I]2-iodo-7,8-dibromodibenzo-p-dioxin.

1988 • 97 citations

Tissue distribution, excretion and biological effects of in rats

1975 • 94 citations

[125I]2-iodo-3,7,8-trichlorodibenzo-p-dioxin-binding species in mouse liver induced by agonists for the Ah receptor: characterization and identification.

1989 • 90 citations

A physiologically based pharmacokinetic model for 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice

1988 • 86 citations

Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in guinea pigs

1986 • 68 citations

Tissue distribution of dioxins and furans in humans from the general population

1985 • 66 citations

Stimulation of in vivo hepatic uptake and in vitro hepatic binding of [125I]2-lodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonist for the Ah receptor.

1989 • 60 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on drug metabolism and hepatic microsomes of rats and mice.

1973 • 51 citations

Hepatic metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat and guinea pig*1

1985 • 49 citations

Relative distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin human hepatic and adipose tissues

1990 • 31 citations

A Proposed Occupational Exposure Limit for 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1988 • 25 citations

Relationship between the murine Ah phenotype and the hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1987 • 21 citations