Relative Liver Tumour Promoting Activity and Toxicity of some Polychlorinated Dibeiizo‐p‐dioxin‐ and Dibenzofuran‐Congeners in Female Sprague‐Dawley Rats

Experimental Design: Procedures for the Behavioral Sciences.

1969 • 5,180 citations

Experimental pathology of the liver

1931 • 3,113 citations

Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal

1931 • 2,491 citations

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)

1990 • 1,872 citations

Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene.

1974 • 1,562 citations

Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450

1985 • 1,272 citations

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

1978 • 1,054 citations

HISTOCHEMICAL AND ULTRASTRUCTURAL DEMONSTRATION OF γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY

1969 • 940 citations

Biochemical characterisation of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine

1978 • 415 citations

Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine.

1980 • 374 citations

The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat

1976 • 303 citations

Tumour promotion by TCDD in skin of HRS/J hairless mice

1982 • 293 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): Results of a 13-week oral toxicity study in rats

1976 • 236 citations

A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci

1987 • 197 citations

ALTERED HEPATIC FOCI: Their Role in Murine Hepatocarcinogenesis

1990 • 189 citations

Disposition and excretion of 2,3,7,8-tetrachlorodibenzofuran in the rat

1980 • 167 citations

Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis.

1991 • 148 citations

Chlorinated Dioxins and Dibenzofurans in Perspective

1987 • 148 citations

Hepatocarcinogenesis in the Rat: The Effect of Promoters and Carcinogens in Vivo and in Vitro

1986 • 119 citations

Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin

1989 • 89 citations

The Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on the Uptake, Distribution and Excretion of a Single Oral Dose of [11,12-3H]Retinyl Acetate and on the Vitamin A Status in the Rat

1985 • 81 citations

The international toxicity equivalency factor (I‐TEF) method for estimating risks associated with exposures to complex mixtures of dioxins and related compounds∗

1990 • 79 citations

Correlation between medium-term liver bioassay system data and results of long-term testing in rats

1990 • 74 citations

Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Syrian golden hamster

1988 • 72 citations

Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) in the Lactating Rat on Maternal and Neonatal Vitamin A Status

1987 • 67 citations

Inhibition of metabolic cooperation in vitro and enhancement of enzyme altered foci incidence in rat liver by the pyrethroid insecticide fenvalerate

1988 • 67 citations

Disposition and excretion of 2,3,4,7,8-pentachlorodibenzofuran in the rat*1

1987 • 54 citations

Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis

1991 • 50 citations

Modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital-induced promotion of hepatocarcinogenesis in rats by the type of diet and vitamin a deficiency

1991 • 31 citations

Some emerging general principles in the pathogenesis of hepatocellular carcinoma.

1986 • 30 citations

Pharmacok inetics and metabolism of 1,2,3,7,8-pentachlorodibenzo-p-dioxin in the rat

1986 • 29 citations

Use of Rat Liver Altered Focus Models for Testing Chemicals that have Completed Two-Year Carcinogenicity Studies

1989 • 28 citations

Tumour promoting effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) - effects of exposure duration, administration schedule and type of diet

1989 • 25 citations

Multistage rodent hepatocarcinogenesis.

1986 • 23 citations

Analytical procedure operating on 0.1-1 ppt level applied in toxicological studies on PCDFs/PCDDs

1990 • 20 citations

Disposition and elimination of three polychlorinated dibenzofurans in the liver of the rat.

1989 • 17 citations

Proliferative Hepatocellular Lesions of the Rat: Review and Future Use in Risk Assessment

1987 • 14 citations

Disposition and elimination of three polychlorinated dibenzofurans in the liver of the rat

1989 • 13 citations

Enhancing effect of 2,3,4,7,8-pentachlorodibenzofuran and 1,2,3,4,7,8-hexachlorodibenzofuran on diethylnitrosamine hepatocarcinogenesis in rats

1986 • 13 citations

Studies on the retention of individual polychlorinated dibenzofurans (PCDFs) in the liver of different species

1990 • 10 citations

Vitamin A storage in rats subchronically exposed to PCDDs/PCDFs

1990 • 6 citations