Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-κB

The biochemistry of apoptosis

2000 • 7,314 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

2003 • 3,164 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

1999 • 997 citations

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

1999 • 888 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

1997 • 678 citations

Structure and function of phosphoinositide 3-kinases

1998 • 666 citations

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

1998 • 653 citations

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.

1997 • 605 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2

1999 • 357 citations

Activation of Akt/Protein Kinase B by G Protein-coupled Receptors

1998 • 333 citations

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1996 • 285 citations

Activation of protein kinase B (Akt/RAC‐protein kinase) by cellular stress and its association with heat shock protein Hsp27

1997 • 270 citations

Rho Family Proteins Modulate Rapid Apoptosis Induced by Cytotoxic T Lymphocytes and Fas

2000 • 244 citations

A Phosphatidylinositol 3-Kinase/Akt Pathway, Activated by Tumor Necrosis Factor or Interleukin-1, Inhibits Apoptosis but Does Not Activate NFκB in Human Endothelial Cells

2000 • 209 citations

Multiple Mitogen-Activated Protein Kinase Signaling Pathways Connect the Cot Oncoprotein to the c-junPromoter and to Cellular Transformation

2000 • 198 citations

A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.

1994 • 195 citations

A Novel Role for Phosphatidylinositol 3-Kinase β in Signaling from G Protein-coupled Receptors to Akt

2000 • 195 citations

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

1996 • 186 citations

cAMP stimulates protein kinase B in a Wortmannin‐insensitive manner

1997 • 169 citations

Rac2 Stimulates Akt Activation Affecting BAD/Bcl-XL Expression while Mediating Survival and Actin Function in Primary Mast Cells

2000 • 168 citations

TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of RhoG

2000 • 166 citations

RhoG GTPase Controls a Pathway That Independently Activates Rac1 and Cdc42Hs

1998 • 162 citations

Small GTPase RhoG Is a Key Regulator for Neurite Outgrowth in PC12 Cells

2000 • 138 citations

The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death

1998 • 128 citations

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis

2000 • 127 citations

Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets.

1990 • 126 citations

The T-Cell Receptor Regulates Akt (Protein Kinase B) via a Pathway Involving Rac1 and Phosphatidylinositide 3-Kinase

2000 • 119 citations

Anti-apoptotic function of Rac in hematopoietic cells

1999 • 88 citations

Interaction of Ras with phosphoinositide 3-kinase γ

1997 • 87 citations

Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons

1999 • 72 citations

Enhanced apoptosis in the thymus of transgenic mice expressing constitutively activated forms of human Rac2GTPase

1997 • 71 citations

Akt negatively regulates the cJun N-terminal kinase pathway in PC12 cells

2000 • 69 citations

Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis

1997 • 65 citations

R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells

2000 • 50 citations

The Signal Response of IκBα Is Regulated by Transferable N- and C-Terminal Domains

1997 • 46 citations

Dual role of Ras and Rho proteins: At the cutting edge of life and death

1998 • 39 citations

Rac-dependent Anti-apoptotic Signaling by the Insulin Receptor Cytoplasmic Domain

1999 • 28 citations

Thrombin-Dependent Association of Phosphatidylinositol-3 Kinase with p60^c-src and p59^fyn in Human Platelets

1990 • 20 citations