Retrovirally Transduced Mouse Dendritic Cells Require CD4+ T Cell Help to Elicit Antitumor Immunity: Implications for the Clinical Use of Dendritic Cells

Dendritic cells and the control of immunity

1998 • 14,345 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Introduction of soluble protein into the class I pathway of antigen processing and presentation

1988 • 1,105 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

1999 • 1,000 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

1999 • 463 citations

Generation of Tumor Immunity by Bone Marrow-Derived Dendritic Cells Correlates with Dendritic Cell Maturation Stage

1999 • 430 citations

CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help

1999 • 423 citations

Cancer vaccines

1998 • 422 citations

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells.

1995 • 357 citations

Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen.

1984 • 351 citations

Presentation of Exogenous Antigen with Class I Major Histocompatibility Complex Molecules

1990 • 338 citations

Induction of antitumor immunity using bone marrow-generated dendritic cells.

1996 • 323 citations

Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity

1995 • 279 citations

TRANCE, a Tumor Necrosis Factor Family Member Critical for CD40 Ligand–independent T Helper Cell Activation

1999 • 262 citations

Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells.

1990 • 210 citations

Dendritic cells require maturation via CD40 to generate protective antitumor immunity.

1998 • 204 citations

Endogenous generation and presentation of the ovalbumin peptide/Kb complex to T cells.

1993 • 185 citations

Recombinant Retroviruses Pseudotyped With the Vesicular Stomatitis Virus G Glycoprotein Mediate Both Stable Gene Transfer and Pseudotransduction in Human Peripheral Blood Lymphocytes

1997 • 169 citations

Cutting Edge: Dendritic Cells Require Maturation via CD40 to Generate Protective Antitumor Immunity

1998 • 155 citations

Monoclonal antibodies to murine CD40 define two distinct functional epitopes

1994 • 152 citations

Interleukin‐12 and B7.1 co‐stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors

1996 • 130 citations

Protective immunity induced by tumor vaccines requires interaction between CD40 and its ligand, CD154.

1997 • 106 citations

Expression of endogenous peptide-major histocompatibility complex class II complexes derived from invariant chain-antigen fusion proteins.

1995 • 106 citations

Requirement for recognition of class II molecules and processed tumor antigen for optimal generation of syngeneic tumor-specific class I-restricted CTL.

1986 • 97 citations

Retrovirally Transduced Human Dendritic Cells Express a Normal Phenotype and Potent T-Cell Stimulatory Capacity

1997 • 85 citations

The Role of B7-1 and B7-2 Costimulation for the Generation of CTL Responses In Vivo

1998 • 73 citations

Enhanced Therapeutic Efficacy of Tumor RNA-Pulsed Dendritic Cells after Genetic Modification with Lymphotactin

1999 • 66 citations

Gene Therapy Protocols

1996 • 48 citations

Impaired Ability of MHC Class II−/− Dendritic Cells to Provide Tumor Protection is Rescued by CD40 Ligation

1999 • 48 citations

Immune regulatory loops determine productive interactions within human T lymphocyte–dendritic cell clusters

1999 • 38 citations

Exogenously Provided Peptides of a Self-antigen Can Be Processed into Forms that Are Recognized by Self–T Cells

1998 • 38 citations

Methods for the Construction of Retroviral Vectors and the Generation of High-Titer Producers

2003 • 30 citations