Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo

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2004 • 10,779 citations

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1991 • 8,402 citations

CHOP Chemotherapy plus Rituximab Compared with CHOP Alone in Elderly Patients with Diffuse Large-B-Cell Lymphoma

2002 • 5,269 citations

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

2002 • 2,400 citations

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

2001 • 1,874 citations

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions

2001 • 1,640 citations

Clinical translation of angiogenesis inhibitors

2002 • 1,518 citations

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

2000 • 1,159 citations

Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1

2002 • 1,066 citations

Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

2003 • 758 citations

Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.

1999 • 660 citations

Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment

2002 • 638 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor Induces Lymphangiogenesis as well as Angiogenesis

2002 • 552 citations

Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies.

1999 • 543 citations

Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells.

2001 • 440 citations

Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration

2000 • 435 citations

Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis.

2001 • 345 citations

Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor–positive human tumors

2001 • 343 citations

Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.

2001 • 300 citations

Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS–Kaposi sarcoma

1997 • 293 citations

Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias

2001 • 275 citations

VEGF165 promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition

2002 • 260 citations

Vascular endothelial growth factor (VEGF)–C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy

2002 • 254 citations

Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function.

1999 • 235 citations

Mechanisms and Future Directions for Angiogenesis-Based Cancer Therapies

2002 • 228 citations

Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non-Hodgkin lymphoma: a single-institution study of 200 patients

2000 • 221 citations

Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis.

2000 • 220 citations

Placental growth factor is a survival factor for tumor endothelial cells and macrophages.

2002 • 209 citations

Role of the tumor microenvironment in mediating de novo resistance to drugs and physiological mediators of cell death

2003 • 202 citations

Vascular endothelial growth factor levels and induction of permeability in malignant pleural effusions.

1999 • 193 citations

A potential autocrine role for vascular endothelial growth factor in prostate cancer.

2002 • 178 citations

Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma.

2001 • 163 citations

Angiogenic growth factors and endostatin in non‐Hodgkin's lymphoma

1999 • 162 citations

Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity

2003 • 160 citations

Vascular endothelial growth factor-A(165) induces progression of melanoma brain metastases without induction of sprouting angiogenesis.

2002 • 151 citations

Clinical trials of antiangiogenic drugs: opportunities, problems, and assessment of initial results.

2001 • 132 citations

A phase I study of anti-kinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma.

2003 • 122 citations

Anti-vascular endothelial growth factor receptor 2 antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type 9 production.

2002 • 121 citations

A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy

2003 • 118 citations

Activity of a Novel Anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against Human Lymphoma is Superior to Methotrexate and Correlates with Tumor RFC-1 Gene Expression

2003 • 114 citations

Role of Vascular Endothelial Growth Factor/Vascular Permeability Factor in the Pathogenesis of Kaposi's Sarcoma-Associated Herpesvirus-Infected Primary Effusion Lymphomas

1999 • 107 citations

Inhibition of vascular endothelial growth factor-induced receptor activation with anti-kinase insert domain-containing receptor single-chain antibodies from a phage display library.

1998 • 105 citations

Vascular endothelial growth factor (VEGF) is expressed by neoplastic Hodgkin–Reed–Sternberg cells in Hodgkin's disease

2002 • 103 citations

Angiozyme: A Novel angiogenesis inhibitor

2001 • 101 citations

Ecstasy danger hits the headlines

2002 • 101 citations

Vascular endothelial growth factor isoforms display distinct activities in promoting tumor angiogenesis at different anatomic sites.

2001 • 95 citations

Role of Vascular Endothelial Growth Factor/Vascular Permeability Factor in the Pathogenesis of Kaposi's Sarcoma-Associated Herpesvirus-Infected Primary Effusion Lymphomas

1999 • 90 citations

Endostatin, an antiangiogenic drug, induces tumor stabilization after chemotherapy or anti-CD20 therapy in a NOD/SCID mouse model of human high-grade non-Hodgkin lymphoma

2000 • 90 citations

Combined anti-fetal liver kinase 1 monoclonal antibody and continuous low-dose doxorubicin inhibits angiogenesis and growth of human soft tissue sarcoma xenografts by induction of endothelial cell apoptosis.

2002 • 90 citations

Propagation of Human Tumors in Antithymocyte Serum-Treated Mice 2

1974 • 89 citations

A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice

1998 • 86 citations

Human myeloid and lymphoid malignancies in the non-obese diabetic/severe combined immunodeficiency mouse model: frequency of apoptotic cells in solid tumors and efficiency and speed of engraftment correlate with vascular endothelial growth factor production.

2000 • 70 citations

Elevated serum endostatin is associated with poor outcome in patients with non-Hodgkin lymphoma

2003 • 55 citations

MUC1 dysregulation as the consequence of a t(1;14)(q21;q32) translocation in an extranodal lymphoma

2000 • 55 citations

Tumorigenicity of Human Malignant Lymphoblasts: Comparative Study With Unmanipulated Nude Mice, Antilymphocyte Serum-Treated Nude Mice, and X-Irradiated Nude Mice23

1980 • 49 citations

Vascular Endothelial Growth Factor/Vascular Permeability Factor in the Pathogenesis of Primary Effusion Lymphomas

2001 • 48 citations

Hemorrhage and VEGF expression in a case of primary CNS lymphoma.

2002 • 43 citations

Immunohistochemical detection of C-kit (CD117) and vascular endothelial growth factor (VEGF) overexpression in mantle cell lymphoma.

2003 • 39 citations

High expression of MCL1 gene related to vascular endothelial growth factor is associated with poor outcome in non‐Hodgkin's lymphoma

2002 • 32 citations

Immunohistochemical Expression of Basic Fibroblast Growth Factor, Vascular Endothelial Growth Factor, and Their Receptors in Stage IV Non-Hodgkin Lymphoma

2002 • 31 citations

Detection of vascular endothelial growth factor in AIDS-related primary effusion lymphomas

2000 • 25 citations

Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums.

2001 • 16 citations

Establishment of a Human Cell Line (SKI-DLCL-1) with a t(1;14)(q21;q32) Translocation from the Ascites of a Patient with Diffuse Large Cell Lymphoma

2001 • 14 citations