The transient receptor potential vanilloid 1: Role in airway inflammation and disease

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1997 • 8,634 citations

The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli

1998 • 3,026 citations

TRP channels as cellular sensors

2003 • 2,625 citations

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

2002 • 2,513 citations

A TRP Channel that Senses Cold Stimuli and Menthol

2002 • 2,182 citations

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

1999 • 2,128 citations

Vanilloid (Capsaicin) receptors and mechanisms.

1999 • 1,825 citations

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

2000 • 1,715 citations

Vasoactive peptide release in the extracerebral circulation of humans during migraine headache

1990 • 1,514 citations

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

2001 • 1,240 citations

p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia

2002 • 1,196 citations

Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine

2004 • 1,150 citations

Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances

2000 • 1,048 citations

Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels

2003 • 983 citations

An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors

2002 • 959 citations

Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

2000 • 926 citations

Cough and Angioneurotic Edema Associated with Angiotensin-Converting Enzyme Inhibitor Therapy

1992 • 902 citations

Induction of vanilloid receptor channel activity by protein kinase C

2000 • 814 citations

Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human

2000 • 798 citations

Hydrogen sulfide is a novel mediator of lipopolysaccharide‐induced inflammation in the mouse

2005 • 754 citations

Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1

2002 • 690 citations

ASTHMA AS AN AXON REFLEX

1986 • 676 citations

Endogenous Airway Acidification

2000 • 644 citations

cAMP-Dependent Protein Kinase Regulates Desensitization of the Capsaicin Receptor (VR1) by Direct Phosphorylation

2002 • 571 citations

A Modular PIP ₂ Binding Site as a Determinant of Capsaicin Receptor Sensitivity

2003 • 521 citations

Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells

2001 • 512 citations

The TRPM7 channel is inactivated by PIP2 hydrolysis

2002 • 509 citations

Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants

1983 • 495 citations

Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide

2001 • 493 citations

Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway

2001 • 466 citations

Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist

2000 • 460 citations

Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1

2002 • 438 citations

Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma.

1996 • 423 citations

Protease-Activated Receptor 2 Sensitizes the Capsaicin Receptor Transient Receptor Potential Vanilloid Receptor 1 to Induce Hyperalgesia

2004 • 399 citations

Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures

2004 • 393 citations

Increased Expression of Transient Receptor Potential Vanilloid-1 in Airway Nerves of Chronic Cough

2004 • 387 citations

Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia

2002 • 356 citations

The VR1 Antagonist Capsazepine Reverses Mechanical Hyperalgesia in Models of Inflammatory and Neuropathic Pain

2003 • 348 citations

Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency

2003 • 329 citations

Protease-Activated Receptor 2 Mediates Eosinophil Infiltration and Hyperreactivity in Allergic Inflammation of the Airway

2002 • 323 citations

Bradykinin Lowers the Threshold Temperature for Heat Activation of Vanilloid Receptor 1

2002 • 319 citations

Protons: small stimulants of capsaicin-sensitive sensory nerves

1994 • 305 citations

Functional Vanilloid Receptors in Cultured Normal Human Epidermal Keratinocytes

2002 • 277 citations

Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease

2000 • 270 citations

N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: II. In Vivo Characterization in Rat Models of Inflammatory and Neuropathic Pain

2003 • 260 citations

Acid stress in the pathology of asthma

2004 • 208 citations

Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea‐pigs

2005 • 207 citations

Regulation of TRP Channels via Lipid Second Messengers

2003 • 205 citations

The vanilloid receptor (VR1)‐mediated effects of anandamide are potently enhanced by the cAMP‐dependent protein kinase

2001 • 205 citations

Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs

1995 • 201 citations

Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function

2004 • 199 citations

Anandamide Excites Central Terminals of Dorsal Root Ganglion Neurons via Vanilloid Receptor-1 Activation

2001 • 194 citations

Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human

2000 • 192 citations

Mechanisms of acid‐induced activation of airway afferent nerve fibres in guinea‐pig

2002 • 176 citations

Hydrogen sulfide causes vanilloid receptor 1‐mediated neurogenic inflammation in the airways

2005 • 159 citations

Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells

2005 • 154 citations

Nerve growth factor (NGF) differentially regulates the chemosensitivity of adult rat cultured sensory neurons

1995 • 148 citations

Allergic and asthmatic reactions to alcoholic drinks

2003 • 138 citations

Vanilloid Receptor 1 Regulates Multiple Calcium Compartments and Contributes to Ca2+-induced Ca2+ Release in Sensory Neurons

2004 • 136 citations

A Role for TRPV1 in Bradykinin-Induced Excitation of Vagal Airway Afferent Nerve Terminals

2002 • 131 citations

Expression of the transient receptor potential vanilloid 1 (TRPV1) in LNCaP and PC-3 prostate cancer cells and in human prostate tissue

2005 • 126 citations

New Light on TRP and TRPL

1997 • 125 citations

EXPRESSION AND CHARACTERIZATION OF THE INTRACELLULAR VANILLOID RECEPTOR (TRPV1) IN BRONCHI FROM PATIENTS WITH CHRONIC COUGH

2005 • 119 citations

Physiology and Plasticity of Putative Cough Fibres in the Guinea Pig

2002 • 118 citations

Antitussive activity of iodo-resiniferatoxin in guinea pigs

2004 • 117 citations

Cough Receptor Sensitivity and Bronchial Responsiveness in Patients with Only Chronic Nonproductive Cough: In View of Effect of Bronchodilator Therapy

1994 • 115 citations

Low pH-induced release of calcitonin gene-related peptide from capsaicin-sensitive sensory nerves: Mechanism of action and biological response

1991 • 111 citations

N-(3-Acyloxy-2-benzylpropyl)-N‘-[4-(methylsulfonylamino)benzyl]thiourea Analogues: Novel Potent and High Affinity Antagonists and Partial Antagonists of the Vanilloid Receptor

2003 • 106 citations

Protease-Activated Receptor-2 Activation Induces Acute Lung Inflammation by Neuropeptide-Dependent Mechanisms

2005 • 105 citations

TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells

2004 • 105 citations

TRPV1 receptors mediate particulate matter-induced apoptosis

2004 • 99 citations

Neurogenic inflammation

1997 • 97 citations

Vanilloid Receptor Expression in the Rat Tongue and Palate

2003 • 94 citations

Recent clinical investigations examining the association of asthma and gastroesophageal reflux

2003 • 93 citations

Cough provocation with capsaicin is an objective way to test sensory hyperreactivity in patients with asthma‐like symptoms

2000 • 92 citations

Cough threshold in patients with chronic obstructive pulmonary disease

1999 • 88 citations

Ethanol Causes Inflammation in the Airways by a Neurogenic and TRPV1-Dependent Mechanism

2004 • 87 citations

Tachykinin and kinin receptor antagonists: therapeutic perspectives in allergic airway disease

1996 • 81 citations

Sensory transduction of pulmonary reactive oxygen species by capsaicin‐sensitive vagal lung afferent fibres in rats

2005 • 78 citations

Immunohistochemical localization of vanilloid receptor subtype 1 (TRPV1) in the guinea pig respiratory system

2005 • 75 citations

Vanilloid receptor activation by 2- and 10-μm particles induces responses leading to apoptosis in human airway epithelial cells

2003 • 70 citations

Characteristics of prostaglandin induced cough in man.

1985 • 64 citations

Role of chloride channels in bradykinin‐induced guinea pig airway vagal C‐fibre activation

2005 • 62 citations

Changes in Levels of Nerve Growth Factor in Nasal Secretions after Capsaicin Inhalation in Patients with Airway Symptoms from Scents and Chemicals

2005 • 60 citations

The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea‐pig airways

2001 • 60 citations

Tachykinin receptor antagonists: potential in airways diseases

2001 • 57 citations

Neuropeptides and their receptors in the immune system.

1999 • 54 citations

Distribution of the vanilloid (capsaicin) receptor type 1 in the human stomach

2005 • 53 citations

Vanilloid (Capsaicin) Receptors Influence Inflammatory Sensitivity in Response to Particulate Matter

2000 • 49 citations

Calcitonin gene‐related peptide and human epicardial coronary arteries: presence, release and vasodilator effects

1991 • 49 citations

Dendritic cells do not transduce inflammatory stimuli via the capsaicin receptor TRPV1

2005 • 45 citations

Effects of intranasal capsaicin challenge on cough reflex in healthy human volunteers.

2004 • 45 citations

NK₁ Receptor Stimulation Causes Contraction and Inositol Phosphate Increase in Medium-size Human Isolated Bronchi

2001 • 44 citations

Capsaicin-like effects of N-arachidonoyl-dopamine in the isolated guinea pig bronchi and urinary bladder

2003 • 38 citations

A Novel Role for Tachykinin Neurokinin-3 Receptors in Regulation of Human Bronchial Ganglia Neurons

2004 • 35 citations

NK₁Receptor Antagonist CP-99,994 Inhibits Cigarette Smoke-Induced Neutrophil and Eosinophil Adhesion in Rat Tracheal Venules

1996 • 32 citations

Capsazepine, a vanilloid antagonist, abolishes tonic responses induced by 20-HETE on guinea pig airway smooth muscle

2004 • 30 citations

Capsaicin releases calcitonin gene-related peptide from the human iris and ciliary body in vitro

1992 • 23 citations

Characterization of tachykinin receptors in ferret trachea by peptide agonists and nonpeptide antagonists

1993 • 20 citations