New Light on TRP and TRPL

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Depletion of intracellular calcium stores activates a calcium current in mast cells

1992 • 1,748 citations

Structural parts involved in activation and inactivation of the sodium channel

1989 • 1,189 citations

Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction

1989 • 1,119 citations

Capacitative calcium entry

1995 • 1,112 citations

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

1993 • 892 citations

Activation of Calcium Entry by the Tumor Promoter Thapsigargin in Parotid Acinar Cells

1989 • 887 citations

Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.

1993 • 752 citations

Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases

1996 • 735 citations

The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors

1992 • 732 citations

trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry

1996 • 688 citations

Isolation of a putative phospholipase c gene of drosophila, norpA, and its role in phototransduction

1988 • 665 citations

Abnormal Electroretinogram from a Drosophila Mutant

1969 • 642 citations

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade

1997 • 625 citations

TRPC1, a human homolog of a Drosophila store-operated channel.

1995 • 623 citations

Competitive binding of α-actinin and calmodulin to the NMDA receptor

1997 • 591 citations

Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene

1992 • 441 citations

Cloning and Functional Expression of a Human Ca2+-Permeable Cation Channel Activated by Calcium Store Depletion

1996 • 391 citations

Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback.

1995 • 370 citations

The Drosophila Light-Activated Conductance Is Composed of the Two Channels TRP and TRPL

1996 • 368 citations

Molecular cloning of a widely expressed human homologue for the Drosophila trp gene

1995 • 351 citations

A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cells

1988 • 344 citations

PDZs and Receptor/Channel Clustering: Rounding Up the Latest Suspects

1996 • 322 citations

Coassembly of TRP and TRPL Produces a Distinct Store-Operated Conductance

1997 • 310 citations

Requirement for the PDZ Domain Protein, INAD, for Localization of the TRP Store-Operated Channel to a Signaling Complex

1997 • 292 citations

A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL.

1996 • 286 citations

Regulation of the TRP Ca2+ Channel by INAD in Drosophila Photoreceptors

1996 • 256 citations

The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency.

1994 • 256 citations

PDZ domains bind carboxy-terminal sequences of target proteins

1996 • 244 citations

Tracing the roots of ion channels

1992 • 235 citations

The Store-Operated Calcium Current ICRAC: Nonlinear Activation by InsP3 and Dissociation from Calcium Release

1997 • 231 citations

Rescue of the Drosophila Phototransduction Mutation trp by Germline Transformation

1985 • 230 citations

Activation of recombinant trp by thapsigargin in Sf9 insect cells

1994 • 226 citations

Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better.

1991 • 222 citations

InsP3 Receptor Is Essential for Growth and Differentiation but Not for Vision in Drosophila

1997 • 222 citations

The transient receptor potential protein (Trp), a putative store-operated Ca2+ channel essential for phosphoinositide-mediated photoreception, forms a signaling complex with NorpA, InaC and InaD.

1996 • 212 citations

Whole-cell recordings of the light induced current in dissociated Drosophila photoreceptors: evidence for feedback by calcium permeating the light-sensitive channels

1991 • 192 citations

Amiloride-sensitive sodium channel is linked to the cytoskeleton in renal epithelial cells.

1991 • 189 citations

A Drosophila mutant defective in extracellular calcium-dependent photoreceptor deactivation and rapid desensitization

1991 • 186 citations

The involvement of ankyrin in the regulation of inositol 1,4,5-trisphosphate receptor-mediated internal Ca2+ release from Ca2+ storage vesicles in mouse T-lymphoma cells.

1993 • 164 citations

Molecular cloning and characterization of the inositol 1,4,5-trisphosphate receptor in Drosophila melanogaster.

1992 • 155 citations

Regulatory arrestin cycle secures the fidelity and maintenance of the fly photoreceptor cell.

1993 • 150 citations

Depletion of intracellular Ca2+ stores activates a Ca(2+)-selective channel in vascular endothelium

1994 • 146 citations

Cytosolic calcium transients: Spatial localization and role in drosophila photoreceptor cell function

1994 • 143 citations

The light response of drosophila photoreceptors is accompanied by an increase in cellular calcium: Effects of specific mutations

1994 • 137 citations

Calcium channels activated by depletion of internal calcium stores in A431 cells

1994 • 131 citations

Detergent solubility of the inositol trisphosphate receptor in rat brain membranes. Evidence for association of the receptor with ankyrin.

1993 • 130 citations

Proper function of the drosophila trp gene product during pupal development is important for normal visual transduction in the adult

1989 • 126 citations

A novel protein encoded by the inad gene regulates recovery of visual transduction in drosophila

1995 • 117 citations

Drosophila homologs of two mammalian intracellular Ca2+-release channels: identification and expression patterns of the inositol 1,4,5- triphosphate and the ryanodine receptor genes

1992 • 116 citations

Drosophila in vision research. The Friedenwald Lecture.

1995 • 115 citations

Role of the actin cytoskeleton on epithelial Na+ channel regulation

1995 • 114 citations

Photolysis of caged Ca2+ facilitates and inactivates but does not directly excite light-sensitive channels in Drosophila photoreceptors

1995 • 112 citations

Flash photolysis of caged inositol 1,4,5-trisphosphate activates plasma membrane calcium current in human T cells.

1993 • 112 citations

Appearance of a Novel Ca2+ Influx Pathway in Sf9 Insect Cells Following Expression of the Transient Receptor Potential-like (trpl) Protein of Drosophila

1994 • 108 citations

Disruption of the IP3 receptor gene of Drosophila affects larval metamorphosis and ecdysone release

1997 • 107 citations

Coexpression of Drosophila TRP and TRP-like proteins in Xenopus oocytes reconstitutes capacitative Ca ²⁺ entry

1996 • 105 citations

Identification of actin filaments in the rhabdomeral microvilli of Drosophila photoreceptors.

1990 • 105 citations

Depletion of Intracellular Calcium Stores Activates a Calcium Conducting Nonselective Cation Current in Mouse Pancreatic Acinar Cells

1996 • 104 citations

Identification of four trp 1 gene variants murine pancreatic beta-cells

1997 • 91 citations

Cytoskeletal regulation of membrane transport events ¹

1994 • 90 citations

Evaluation of Calcium Influx Factors from Stimulated Jurkat T-lymphocytes by Microinjection into Xenopus Oocytes

1995 • 86 citations

The Drosophila cation channel trpl expressed in insect Sf9 cells is stimulated by agonists of G‐protein‐coupled receptors

1995 • 77 citations

Calcium pools, calcium entry, and cell growth

1996 • 76 citations

Genetic dissection of light-induced Ca2+ influx into Drosophila photoreceptors.

1994 • 74 citations

Direct activation of trpl cation channels by G alpha11 subunits.

1996 • 68 citations

Calcium-dependent inactivation of light-sensitive channels in Drosophila photoreceptors.

1994 • 68 citations

The COOH-terminal Domain of Drosophila TRP Channels Confers Thapsigargin Sensitivity

1996 • 65 citations

TRP, a protein essential for inositide-mediated Ca2+ influx is localized adjacent to the calcium stores in Drosophila photoreceptors

1995 • 63 citations

Ins(1,4,5)P3 activates Drosophila cation channel Trpl in recombinant baculovirus-infected Sf9 insect cells

1995 • 63 citations

Capacitative calcium entry is colocalised with calcium release in Xenopus oocytes: Evidence against a highly diffusible calcium influx factor

1996 • 58 citations

Calmodulin Regulation of Calcium Stores in Phototransduction of Drosophila

1997 • 57 citations

Lanthanum reduces the excitation efficiency in fly photoreceptors.

1991 • 54 citations

Magnesium-dependent block of the light-activated and trp-dependent conductance in Drosophila photoreceptors

1995 • 53 citations

Intercellular and intracellular signals and their transduction via the plasma membrane-cytoskeleton interface

1993 • 52 citations

Membrane-Associated Phospholipase C of Drosophila Retina1

1988 • 49 citations

Excitation of Drosophila photo-receptors by BAPTA and ionomycin: evidence for capacitative Ca2+ entry?

1996 • 46 citations

Expression of Drosophila trpl cRNA in Xenopus laevis oocytes leads to the appearance of a Ca2+ channel activated by Ca2+ and calmodulin, and by guanosine 5′[γ-thio]triphosphate

1996 • 46 citations

Properties of single Drosophila Trpl channels expressed in Sf9 insect cells

1997 • 45 citations

Depletion and refilling of intracellular Ca2+ stores induce oscillations of Ca2+ current

1993 • 39 citations

Cloning and expression localization of cDNA for rat homolog of TRP protein, a possible store-operated calcium (Ca2+) channel

1996 • 36 citations

Calmodulin regulation of light adaptation and store-operated dark current in Drosophila photoreceptors

1997 • 35 citations

Isolation, Cloning, and Characterisation of a trp Homologue from Squid (Loligo forbesi) Photoreceptor Membranes

1996 • 30 citations

Ca2+ entry induced by calcium influx factor and its regulation by protein kinase C in rabbit neutrophils

1996 • 15 citations