An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1997 • 8,634 citations

Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor

2000 • 3,436 citations

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

1999 • 2,128 citations

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

1996 • 2,079 citations

Vanilloid (Capsaicin) receptors and mechanisms.

1999 • 1,825 citations

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

2000 • 1,715 citations

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

2001 • 1,240 citations

Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances

2000 • 1,048 citations

Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers

2002 • 871 citations

Induction of vanilloid receptor channel activity by protein kinase C

2000 • 814 citations

Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human

2000 • 798 citations

The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)

2000 • 766 citations

N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo

2000 • 360 citations

The Activity of Anandamide at Vanilloid VR1 Receptors Requires Facilitated Transport across the Cell Membrane and Is Limited by Intracellular Metabolism

2001 • 352 citations

Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin‐like activity

2000 • 344 citations

Identification of a New Class of Molecules, the Arachidonyl Amino Acids, and Characterization of One Member That Inhibits Pain

2001 • 330 citations

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1

2000 • 305 citations

Protons: small stimulants of capsaicin-sensitive sensory nerves

1994 • 305 citations

Iodo-Resiniferatoxin, a New Potent Vanilloid Receptor Antagonist

2001 • 256 citations

New perspectives on enigmatic vanilloid receptors

2000 • 218 citations

Anandamide Excites Central Terminals of Dorsal Root Ganglion Neurons via Vanilloid Receptor-1 Activation

2001 • 194 citations

The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes

2000 • 194 citations

Ion channels gated by heat

1999 • 173 citations

The distribution and regulation of vanilloid receptor VR1 and VR1 5′ splice variant RNA expression in rat

2001 • 164 citations

The uptake by cells of 2‐arachidonoylglycerol, an endogenous agonist of cannabinoid receptors

2001 • 155 citations

The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice

2001 • 128 citations

Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues

2001 • 127 citations

Ruthenium red and capsazepine antinociceptive effect in formalin and capsaicin models of pain in mice

1997 • 127 citations

Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat

1988 • 114 citations

Analogs of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 3. The hydrophobic side-chain "C-region"

1993 • 108 citations

A capsaicin-receptor antagonist, capsazepine, reduces inflammation-induced hyperalgesic responses in the rat: evidence for an endogenous capsaicin-like substance

1998 • 105 citations

The Tissue Distribution and Functional Characterization of Human VR1

2001 • 97 citations

Pharmacological characterization of vanilloid receptor located in the brain

2002 • 88 citations

Specific binding of [3H]resiniferatoxin by human and rat preoptic area, locus ceruleus, medial hypothalamus, reticular formation and ventral thalamus membrane preparations

1996 • 80 citations

Fatty acid acylation of dopamine in the carotid body

1998 • 18 citations