Cholera toxin and cholera B subunit as oral—mucosal adjuvant and antigen vector systems

The mucosal immune system: from fundamental concepts to vaccine development

1992 • 912 citations

Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin

1992 • 810 citations

New knowledge on pathogenesis of bacterial enteric infections as applied to vaccine development

1983 • 573 citations

Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli

1991 • 556 citations

Actions of cholera toxin and the prevention and treatment of cholera

1981 • 532 citations

Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin.

1984 • 445 citations

Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens.

1986 • 428 citations

Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin.

1992 • 369 citations

Cellular kinetics of the intestinal immune response to cholera toxoid in rats.

1975 • 353 citations

The adjuvant effect of Vibrio cholerae and Escherichia coli heat‐labile enterotoxins is linked to their ADP‐ribosyltransferase activity

1992 • 286 citations

Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens

1988 • 283 citations

Transport of membrane-bound macromolecules by M cells in follicle-associated epithelium of rabbit Peyer's patch

1987 • 253 citations

Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues

1989 • 252 citations

Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation.

1990 • 238 citations

Mucosal Antitoxic and Antibacterial Immunity after Cholera Disease and after Immunization with a Combined B Subunit-Whole Cell Vaccine

1984 • 235 citations

Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium.

1986 • 202 citations

Regulation of interleukin 2 synthesis by cAMP in human T cells.

1987 • 197 citations

Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro.

1991 • 192 citations

Cyclic AMP--an intracellular second messenger for interleukin 1.

1988 • 182 citations

Mucosal Immunity: Implications for Vaccine Development

1992 • 166 citations

Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development.

1989 • 161 citations

Induction of Mucosal and Systemic Immunity to a Recombinant Simian Immunodeficiency Viral Protein

1992 • 142 citations

Antibody-producing cells in peripheral blood and salivary glands after oral cholera vaccination of humans

1991 • 142 citations

Oral administration of cholera toxin-Sendai virus conjugate potentiates gut and respiratory immunity against Sendai virus.

1988 • 133 citations

The in vitro production of cytokines by mucosal lymphocytes immunized by oral administration of keyhole limpet hemocyanin using cholera toxin as an adjuvant

1991 • 120 citations

Immunological Disorders in Infants and Children

1996 • 104 citations

Cellular basis of immunomodulation by cholera toxin in vitro with possible association to the adjuvant function in vivo.

1989 • 100 citations

Cholera Toxin as a Mucosal Adjuvant

1996 • 91 citations

Cholera toxin promotes B cell isotype differentiation.

1989 • 90 citations

Cholera Toxin Enhances Alloantigen Presentation by Cultured Intestinal Epithelial Cells

1993 • 88 citations

Whole Cholera Toxin and B Subunit Act Synergistically as an Adjuvant for the Mucosal Immune Response of Mice to Keyhole Limpet Haemocyanin

1990 • 87 citations

Correlation between intestinal synthesis of specific immunoglobulin A and protection against experimental cholera in mice

1978 • 80 citations

A single amino acid substitution in the A subunit of Escherichia coli enterotoxin results in a loss of its toxic activity.

1990 • 73 citations

Cholera toxin acts synergistically with IL-4 to promote IgG1 switch differentiation.

1990 • 73 citations

Antigen processing by isolated rat intestinal villus enterocytes.

1989 • 64 citations

A single amino acid substitution in the A subunit of Escherichia coli enterotoxin results in a loss of its toxic activity.

1990 • 60 citations

Bacterial infections of respiratory and gastrointestinal mucosae

1988 • 59 citations

Cholera holotoxin and its B subunit enhance Peyer's patch B cell responses induced by orally administered influenza virus: Disproportionate cholera toxin enhancement of the IgA B cell response

1990 • 58 citations

Effects of anti-proliferative cyclic AMP on interleukin 2-stimulated gene expression.

1987 • 57 citations

Mucosal priming of T-lymphocyte responses to fed protein antigens using cholera toxin as an adjuvant.

1991 • 53 citations

Proliferation and differentiation of human CD5⁺ and CD5⁻ B cell subsets activated through their antigen receptors or CD40 antigens

1992 • 48 citations

H-2-unrestricted adjuvant effect of cholera toxin B subunit on murine antibody responses to influenza virus haemagglutinin.

1991 • 44 citations

Cholera toxin inhibits resting human T cell activation via a cAMP-independent pathway.

1989 • 41 citations

Cholera Toxin, Ganglioside Receptors and the Immune Response

1976 • 35 citations

New Strategies for Oral Immunization

1989 • 28 citations

Antigen recognition in the gastrointestinal tract: Death to the dogma

1991 • 16 citations

Molecular effects of cholera toxin on isotype differentiation

1991 • 10 citations