Death without caspases, caspases without death

Caspases: Enemies Within

1998 • 6,923 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Induction of autophagy and inhibition of tumorigenesis by beclin 1

1999 • 3,194 citations

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

1999 • 2,796 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

IAP proteins: blocking the road to death's door

2002 • 1,753 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Apoptosis in neurodegenerative disorders

2000 • 1,542 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

2001 • 1,327 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

A matter of life and death

2002 • 1,251 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

2003 • 1,214 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Programmed cell death

1974 • 966 citations

Prevention of Apoptosis by a Baculovirus Gene During Infection of Insect Cells

1991 • 810 citations

Defects in regulation of apoptosis in caspase-2-deficient mice

1998 • 688 citations

Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE

1998 • 687 citations

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

2002 • 685 citations

Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

1999 • 631 citations

A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases

1998 • 611 citations

Signals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo

1995 • 601 citations

The harlequin mouse mutation downregulates apoptosis-inducing factor

2002 • 595 citations

Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene

1997 • 549 citations

Caspase 3 activity is required for skeletal muscle differentiation

2002 • 541 citations

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

2003 • 467 citations

Regulation of apoptosis by Bcl‐2 family proteins

2003 • 449 citations

Autophagy Is Activated by Apoptotic Signalling in Sympathetic Neurons: An Alternative Mechanism of Death Execution

1999 • 424 citations

Caspase Activity and a Specific Cytochrome C Are Required for Sperm Differentiation in Drosophila

2003 • 412 citations

The Drosophila caspase Dredd is required to resist Gram‐negative bacterial infection

2000 • 391 citations

Steroid regulated programmed cell death during Drosophila metamorphosis

1997 • 386 citations

Caspase Activation Is Required for Terminal Erythroid Differentiation

2001 • 383 citations

Mechanisms of AIF-Mediated Apoptotic DNA Degradation in Caenorhabditis elegans

2002 • 375 citations

Autophagy, Cytoplasm-to-Vacuole Targeting Pathway, and Pexophagy in Yeast and Mammalian Cells

2000 • 359 citations

Phagocytosis promotes programmed cell death in C. elegans

2001 • 348 citations

Steroid regulation of autophagic programmed cell death during development

2001 • 330 citations

The Drosophila caspase DRONC is regulated by DIAP1

2000 • 322 citations

DCP-1, a Drosophila Cell Death Protease Essential for Development

1997 • 312 citations

Specific involvement of caspases in the differentiation of monocytes into macrophages

2002 • 306 citations

Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans

2002 • 300 citations

Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice

1998 • 300 citations

Non‐specific effects of methyl ketone peptide inhibitors of caspases

1999 • 298 citations

Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans

2001 • 297 citations

A Novel Protein Complex Linking the δ2 Glutamate Receptor and Autophagy

2002 • 295 citations

A Role for Caspases in Lens Fiber Differentiation

1998 • 294 citations

Caspase knockouts: matters of life and death

1999 • 279 citations

A Steroid-Triggered Transcriptional Hierarchy Controls Salivary Gland Cell Death during Drosophila Metamorphosis

2000 • 269 citations

Caspases function in autophagic programmed cell death inDrosophila

2003 • 259 citations

WD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 Activation

1998 • 252 citations

Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities.

1996 • 236 citations

Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing

2000 • 236 citations

Specific Double-Stranded RNA Interference in Undifferentiated Mouse Embryonic Stem Cells

2001 • 226 citations

Calcium and Calpain as Key Mediators of Apoptosis-like Death Induced by Vitamin D Compounds in Breast Cancer Cells

2002 • 216 citations

Terminal Differentiation of Human Keratinocytes and Stratum Corneum Formation is Associated with Caspase-14 Activation

2000 • 214 citations

Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53.

1999 • 213 citations

A SAGE Approach to Discovery of Genes Involved in Autophagic Cell Death

2003 • 211 citations

Genome-Wide Analyses of Steroid- and Radiation-Triggered Programmed Cell Death in Drosophila

2003 • 206 citations

An Essential Role for the Caspase Dronc in Developmentally Programmed Cell Death in Drosophila

2000 • 160 citations

Requirement for DCP-1 Caspase During Drosophila Oogenesis

1998 • 159 citations

Cleavage of CPP32 by Granzyme B Represents a Critical Role for Granzyme B in the Induction of Target Cell DNA Fragmentation

1996 • 148 citations

Granzyme B-induced loss of mitochondrial inner membrane potential (Delta Psi m) and cytochrome c release are caspase independent.

1999 • 133 citations

Morphology of programmed cell death in the ventral nerve cord of Caenorhabditis elegans larvae

1982 • 132 citations

Caspase-11 Mediates Oligodendrocyte Cell Death and Pathogenesis of Autoimmune-Mediated Demyelination

2001 • 120 citations

The lurcher gene induces apoptotic death in cerebellar Purkinje cells

1995 • 119 citations

Suppression of CED-3-independent apoptosis by mitochondrial βNAC in Caenorhabditis elegans

2003 • 109 citations

Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex

2002 • 100 citations

Granzyme B-Induced Loss of Mitochondrial Inner Membrane Potential (ΔΨm) and Cytochrome c Release Are Caspase Independent

1999 • 99 citations

Members of the Bcl-2 and Caspase Families Regulate Nuclear Degeneration during Chick Lens Fibre Differentiation

1999 • 95 citations

Mutational Analysis of the Caenorhabditis elegans Cell-Death Gene ced-3

1999 • 91 citations

Identification of Multiple Caenorhabditis elegansCaspases and Their Potential Roles in Proteolytic Cascades

1998 • 89 citations

Decreased apoptosis in proliferative and postmitotic regions of the caspase 3-deficient embryonic central nervous system

2000 • 83 citations

A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes

1996 • 76 citations

Detection of Activated Caspase-3 by a Cleavage Site-Directed Antiserum during Naturally Occurring DRG Neurons Apoptosis

1998 • 67 citations

The Apoptotic and Nonapoptotic Nature of the Terminal Differentiation of Erythroid Cells

1998 • 56 citations

The V410I (G1228A) variant of the caspase-10 gene is a common polymorphism in the Danish population

2000 • 40 citations

Programmed cell death: Superman meets Dr Death

2003 • 13 citations