Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.

1985 • 1,052 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

Mice develop normally without tenascin.

1992 • 590 citations

Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.

1991 • 528 citations

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs.

1992 • 450 citations

IL-4 induces a Th2 response in Leishmania major-infected mice.

1992 • 403 citations

Targeted disruption of the MHC class II Aa gene in C57BL/6 mice

1993 • 377 citations

Negative feedback regulation of IgE synthesis by murine CD23

1994 • 250 citations

Retrovirus-induced immunodeficiency in the mouse

1992 • 221 citations

Establishment of a germ-line competent C57BL/6 embryonic stem cell line

1991 • 204 citations

A New Inbred Subline of Mice (129/terSv) with a High Incidence of Spontaneous Congenital Testicular Teratomas2

1973 • 198 citations

Induction of Plasma Cell Tumours in BALB/c Mice with 2,6,10,14-Tetramethylpentadecane (Pristane)

1969 • 196 citations

Spleen cell cytokine secretion in Mycobacterium bovis BCG-infected mice

1992 • 171 citations

Atherosclerosis and plasma and liver lipids in nine inbred strains of mice

1993 • 162 citations

Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa.

1993 • 160 citations

Mouse teratocarcinoma cells: Prospects for the study of embryogenesis and neoplasia

1981 • 152 citations

Resistance of Mice Deficient in IL-4 to Retrovirus-Induced Immunodeficiency Syndrome (MAIDS)

1993 • 112 citations

Kinetic analysis of antigen-specific immune responses in resistant and susceptible mice during infection with Trypanosoma cruzi.

1993 • 96 citations

Targeting of the creating kinase M gene in embryonic stem cells using isogenic and nonisogenic vectors

1992 • 89 citations

Single gene control of resistance to cutaneous leishmaniasis in mice

1981 • 83 citations

Anti-CD3 antibody induces rapid expression of cytokine genes in vivo.

1990 • 70 citations

Induction of murine T-helper-cell responses to the filarial nematode Brugia malayi

1993 • 48 citations

Anti-CD3 antibodies induce T cells from unprimed animals to secrete IL-4 both in vitro and in vivo.

1990 • 39 citations

Portal shunting and resistance to Schistosoma mansoni in 129 strain mice

1989 • 39 citations

Differential Susceptibility of BALB/c Sublines to Diabetes Induction by Multi-Dose Streptozotocin Treatment

1985 • 29 citations

Quick nested PCR screening of ES cell clones for gene targeting events.

1993 • 29 citations

Deleted Work

1955 • 0 citations