Potentiation of Insulin-Induced Phosphatidylinositol-3 Kinase Activity by Phorbol Ester Is Mediated by Protein Kinase Cϵ

Oncogenes and signal transduction

1991 • 2,816 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

1996 • 568 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

1993 • 546 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

Tumor Promoters and the Mechanism of Tumor Promotion

1980 • 415 citations

Disruption of PDGF Receptor Trafficking by Mutation of Its PI-3 Linase Binding Sites

1994 • 297 citations

The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts.

1993 • 222 citations

Dissociation of CH ₄ at High Pressures and Temperatures: Diamond Formation in Giant Planet Interiors?

1999 • 204 citations

Association of p21ras with phosphatidylinositol 3-kinase.

1991 • 174 citations

Studies on the Mechanisms Involved in Multistage Carcinogenesis in Mouse Skin

1982 • 163 citations

Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling.

1993 • 162 citations

Sequential Aspects of Chemical Carcinogenesis: Skin

1975 • 159 citations

Requirement for Phosphatidylinositol 3-Kinase in Epidermal Growth Factor-Induced AP-1 Transactivation and Transformation in JB6 P⁺ Cells

1996 • 150 citations

Effects of insulin and protein synthesis inhibitors on phospholipid metabolism, diacylglycerol levels, and pyruvate dehydrogenase activity in BC3H-1 cultured myocytes.

1984 • 136 citations

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.

1994 • 130 citations

Phosphatidylinositol-3 Kinase Is Necessary for 12-O-Tetradecanoylphorbol-13-acetate-induced Cell Transformation and Activated Protein 1 Activation

1997 • 112 citations

Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells.

1996 • 99 citations

Bombesin, platelet-derived growth factor, and diacylglycerol induce selective membrane association and down-regulation of protein kinase C isotypes in Swiss 3T3 cells.

1994 • 93 citations

Protein Kinase C δ Specifically Associates with Phosphatidylinositol 3-Kinase Following Cytokine Stimulation

1996 • 84 citations

Transformation reversion induced in JB6 RT101 cells by AP-1 inhibitors

1995 • 83 citations

Protein Kinase C ∊ Subcellular Localization Domains and Proteolytic Degradation Sites

1995 • 76 citations

Activation of Protein Kinase Cα Inhibits Signaling by Members of the Insulin Receptor Family

1995 • 74 citations

A Cloning and ϵ-Epitope-Tagging Insert for the Expression of Polymerase Chain Reaction-Generated cDNA Fragments in Escherichia coli and Mammalian Cells

1994 • 64 citations

Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta.

1994 • 61 citations

Overexpressed protein kinase C-delta and -epsilon subtypes in NIH 3T3 cells exhibit differential subcellular localization and differential regulation of sodium-dependent phosphate uptake.

1994 • 50 citations

Selective Inhibition of p70 S6 Kinase Activation by Phosphatidylinositol 3‐Kinase Inhibitors

1995 • 48 citations

Phospholipid signaling systems in insulin action

1988 • 38 citations

Interactions of Protein Kinase C with Insulin Signaling

1996 • 29 citations

Phorbol ester stimulates phosphorylation on serine 1327 of the human insulin receptor

1994 • 28 citations

Agonist-induced association of the p21rasGTPase-activating protein with phosphatidylinositol 3-kinase

1992 • 19 citations

Synergistic Effects of Insulin and Phorbol Ester on Mitogen-activated Protein Kinase in Rat-1 HIR Cells

1996 • 18 citations

Diacylglycerol directly stimulates the insulin receptor tyrosine kinase

1996 • 17 citations

Effects of phorbol esters on insulin‐induced activation of phosphatidylinositol 3‐kinase, glucose transport, and glycogen synthase in rat adipocytes

1996 • 17 citations

Wortmannin has opposite effects on phorbol ester‐induced DNA synthesis and phosphatidylcholine hydrolysis

1995 • 13 citations