Diacylglycerol directly stimulates the insulin receptor tyrosine kinase

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

A rapid, sensitive method for detection of alkaline phosphatase-conjugated anti-antibody on Western blots

1984 • 2,189 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

After Insulin Binds

1987 • 687 citations

Membrane Receptors

1974 • 636 citations

Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.

1988 • 315 citations

Inositol phospholipid-specific phospholipase C: interaction of the γ isoform with tyrosine kinase

1991 • 233 citations

The nature of protein kinase C activation by physically defined phospholipid vesicles and diacylglycerols.

1985 • 228 citations

Modification by diacylglycerol of the structure and interaction of various phospholipid bilayer membranes

1986 • 225 citations

The New Elements of Insulin Signaling: Insulin Receptor Substrate-1 and Proteins With SH2 Domains

1993 • 221 citations

Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies.

1986 • 217 citations

Insulin Rapidly Increases Diacylglycerol by Activating De Novo Phosphatidic Acid Synthesis

1987 • 200 citations

Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol.

1992 • 180 citations

Insulin-stimulated diacylglycerol production results from the hydrolysis of a novel phosphatidylinositol glycan.

1987 • 166 citations

Long-chain unsaturated diacylglycerols cause A perturbation in the structure of phospholipid bilayers rendering them susceptible to phospholipase attack

1984 • 159 citations

Diacylglycerol causes major structural transitions in phospholipid bilayer membranes

1984 • 121 citations

Diacylglycerol potentiates phospholipase attack upon phospholipid bilayers: Possible connection with cell stimulation

1983 • 120 citations

Translocation of CTP:phosphocholine cytidylyltransferase from cytosol to membranes in HeLa cells: stimulation by fatty acid, fatty alcohol, mono- and diacylglycerol

1987 • 119 citations

The direct measurement of protein kinase C (PKC) activity in isolated membranes using a selective peptide substrate

1991 • 110 citations

Stimulation of Ca2+-activated human platelet phospholipase A2 by diacylglycerol

1987 • 98 citations

Phosphatidic acid and diacylglycerol synergize in a cell-free system for activation of NADPH oxidase from human neutrophils.

1993 • 96 citations

Characterization of mixed micelles of phospholipids of various classes and a synthetic, homogeneous analogue of the nonionic detergent triton X-100 containing nine oxyethylene groups

1978 • 77 citations

Structural basis of protein kinase C activation by diacylglycerols and tumor promoters

1992 • 72 citations

Mechanisms whereby insulin increases diacylglycerol in BC3H-1 myocytes

1988 • 69 citations

Inhibition of the insulin receptor tyrosine kinase by sphingosine

1991 • 62 citations

Insulin Receptor Autophosphorylation and Signaling is Altered by Modulation of Membrane Physical Properties

1995 • 60 citations

Diacylglycerol stimulates phospholipase A₂ from Swiss 3T3 fibroblasts

1988 • 57 citations

Structural studies on the diglyceride-mediated activation of protein kinase C.

1988 • 46 citations

Effect of diacylglycerols on the activity of cobra venom, bee venom, and pig pancreatic phospholipases A2

1992 • 41 citations

Phorbol ester-mediated protein kinase C interaction with wild-type and COOH-terminal truncated insulin receptors.

1991 • 40 citations

Insulin stimulates the generation of two putative insulin mediators, inositol-glycan and diacylglycerol in BC3H-1 myocytes

1991 • 35 citations

Insulin-stimulated serine and threonine phosphorylation of the human insulin receptor. An assessment of the role of serines 1305/1306 and threonine 1348 by their replacement with neutral or negatively charged amino acids.

1991 • 34 citations

Stimulation of phospholipase C activity by insulin is mediated by both isotypes of the human insulin receptor

1991 • 16 citations

Insulin-stimulated phosphatidylcholine hydrolysis, diacylglycerol/protein kinase C signalling, and hexose transport in pertussis toxin-treated BC3H-1 myocytes

1994 • 14 citations

Diacylglycerol Modulation of Insulin Receptor From Cultured Human Mononuclear Cells: Effects on Binding and Internalization

1986 • 13 citations

Diacylglycerols modulate phosphorylation of the insulin receptor from human mononuclear cells

1990 • 11 citations