A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth

Protein Kinases* *Support of the National Institutes of Arthritis and Metabolic Diseases, NIH, U. S. Public Health Service (AM 12842), the Muscular Dystrophy Association of America, and the American Heart Association is acknowledged.

1972 • 416 citations

Advances in Cyclic Nucleotide and Protein Phosphorylation Research

1975 • 373 citations

Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase.

1986 • 286 citations

Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapy.

1990 • 281 citations

Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase.

1986 • 275 citations

Reversible autophosphorylation of a cyclic 3':5'-AMP-dependent protein kinase from bovine cardiac muscle.

1975 • 253 citations

Cyclic-AMP-dependent protein kinase type II is associated with the Golgi complex and with centrosomes

1985 • 234 citations

Molecular Cloning of a Tissue-Specific Protein Kinase (C_γ) from Human Testis—Representing a Third Isoform for the Catalytic Subunit of cAMP-Dependent Protein Kinase

1990 • 232 citations

Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase.

1988 • 212 citations

A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase.

1986 • 206 citations

Regulation of the cellular and subcellular concentrations and distribution of cyclic nucleotide-dependent protein kinases.

1984 • 153 citations

Analysis of the cAMP-Dependent Protein Kinase System Using Molecular Genetic Approaches

1988 • 148 citations

8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells.

1993 • 136 citations

Molecular Cloning, Complementary Deoxyribonucleic Acid Structure and Predicted Full-Length Amino Acid Sequence of the Hormone-lnducible Regulatory Subunit of 3′-5′-Cyclic Adenosine Monophosphate-Dependent Protein Kinase from Human Testis

1988 • 124 citations

Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.

1991 • 108 citations

Holoenzymes of cAMP-dependent protein kinase containing the neural form of type I regulatory subunit have an increased sensitivity to cyclic nucleotides.

1990 • 106 citations

Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis

1987 • 103 citations

cAMP‐dependent protein kinase: prototype for a family of enzymes

1988 • 99 citations

In vivo studies with phosphorothioate oligonucleotides: pharmacokinetics prologue.

1991 • 96 citations

An antisense oligodeoxynucleotide that depletes RI alpha subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells.

1993 • 88 citations

An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects.

1990 • 85 citations

Reverse transformation of Harvey murine sarcoma virus-transformed NIH/3T3 cells by site-selective cyclic AMP analogs.

1988 • 57 citations

Hormonal activation of gene transcription in ras-transformed NIH3T3 cells overexpressing RII alpha and RII beta subunits of the cAMP-dependent protein kinase.

1991 • 49 citations

cAMP-dependent protein kinases I and II: divergent turnover of subunits

1986 • 48 citations

A unique mRNA species for a regulatory subunit of cAMP‐dependent protein kinase is specifically induced in haploid germ cells

1988 • 47 citations

Purification and characterization of an inactive form of cAMP-dependent protein kinase containing bound cAMP.

1987 • 40 citations

Presence of the sites for interacting with cyclic AMP and with catalytic subunit on small fragments of protein kinase regulatory subunit.

1978 • 28 citations

Identification of a ternary complex between cAMP and a trimeric form of cAMP-dependent protein kinase.

1986 • 22 citations

Compartmentalization of regulatory subunits of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in MCF-7 human breast cancer cells.

1983 • 18 citations

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