Development and function of T cells in mice with a disrupted CD2 gene.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium

1985 • 1,983 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

1984 • 1,132 citations

The Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune System

1987 • 1,104 citations

Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3.

1982 • 740 citations

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

1986 • 727 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Role of Lymphocyte Adhesion Receptors in Transient Interactions and Cell Locomotion

1991 • 532 citations

The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3

1987 • 453 citations

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules

1992 • 438 citations

Identification of a human T lymphocyte surface protein associated with the E-rosette receptor.

1981 • 419 citations

Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice

1991 • 307 citations

The B-cell surface protein CD72/Lyb-2 is the ligand for CDS

1991 • 305 citations

A human T lymphocyte differentiation marker defined by monoclonal antibodies that block E-rosette formation.

1981 • 281 citations

Transformation of yeast spheroplasts without cell fusion

1987 • 266 citations

Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion.

1987 • 259 citations

Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand

1987 • 251 citations

Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.

1992 • 226 citations

Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens.

1987 • 213 citations

Activation of human thymocytes via the 50KD T11 sheep erythrocyte binding protein induces the expression of interleukin 2 receptors on both T3+ and T3- populations.

1985 • 170 citations

Overlapping but Nonidentical Binding Sites on CD2 for CD58 and a Second Ligand CD59

1992 • 165 citations

The Structural Biology of CD2

1989 • 154 citations

Suppression of human T-cell mitogenesis and E-rosette formation by the monoclonal antibody OKT11A.

1981 • 151 citations

Association of CD2 and CD45 on human T lymphocytes

1990 • 139 citations

The CD2 antigen associates with the T-cell antigen receptor CD3 antigen complex on the surface of human T lymphocytes

1989 • 127 citations

The cell surface molecule recognized by the erythrocyte receptor of T lymphocytes. Identification and partial characterization using a monoclonal antibody.

1985 • 105 citations

Phenomenon of human T cells rosetting with sheep erythrocytes analyzed with monoclonal antibodies. "Modulation" of a partially hidden epitope determining the conditions of interaction between T cells and erythrocytes

1982 • 104 citations

Anti-CD2 antibodies induce T cell unresponsiveness in vivo.

1991 • 90 citations

CD3 zeta dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells.

1992 • 88 citations

Isoform‐specific associations of CD45 with accessory molecules in human T lymphocytes

1992 • 84 citations

Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation.

1987 • 84 citations

T cell stimulation via the erythrocyte receptor. Synergism between monoclonal antibodies and phorbol myristate acetate without changes of free cytoplasmic Ca++ levels.

1986 • 81 citations

The T cell receptor/CD3 complex and CD2 stimulate the tyrosine phosphorylation of indistinguishable patterns of polypeptides in the human T leukemic cell line Jurkat

1991 • 72 citations

The murine homologue of the T lymphocyte CD2 antigen: molecular cloning, chromosome assignment and cell surface expression

1987 • 68 citations

Activation of rat T lymphocytes by anti-CD2 monoclonal antibodies.

1988 • 67 citations

Relative contribution of CD2 and LFA-1 to murine T and natural killer cell functions.

1990 • 56 citations

Signal transduction by the CD2 antigen in T cells and natural killer cells: requirement for expression of a functional T cell receptor or binding of antibody Fc to the Fc receptor, Fc gamma RIIIA (CD16).

1991 • 55 citations

Rosetting of human T lymphocytes with sheep and human erythrocytes. Comparison of human and sheep ligand binding using purified E receptor.

1987 • 41 citations

CD2 can mediate TCR/CD3-independent T cell activation.

1991 • 39 citations

Subsets of thymopoietic rat thymocytes defined by expression of the CD2 antigen and the MRC OX‐22 determinant of the leukocyte‐common an

1989 • 38 citations

Distribution and ontogeny of CD2 expression by murine T cells.

1989 • 37 citations

Expression and function of CD2 during murine thymocyt

1989 • 36 citations

Murine CD2 gene expression during fetal thymus ontogeny

1988 • 35 citations

Induction of negative signal through CD2 during antigen-specific T cell activation.

1991 • 34 citations

Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes.

1988 • 31 citations

The effects of anti‐CD2 antibodies on the differentiation of mouse thymocytes

1989 • 25 citations

A Phenotype or Not: Targeting Genes in the Immune System

1992 • 21 citations

Reconstitution of an active surface CD2 by DNA transfer in CD2-CD3+ Jurkat cells facilitates CD3-T cell receptor-mediated IL-2 production.

1991 • 19 citations

Mouse LFA‐3 studied with chimeric soluble CD2 shows preferential expression on lymphoid cells

1991 • 17 citations