Replicative senescence in organ transplantation—mechanisms and significance

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Longitudinal Studies on the Rate of Decline in Renal Function with Age

1985 • 1,531 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1996 • 944 citations

Bypass of Senescence After Disruption of p21 ^CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

1997 • 797 citations

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

1993 • 743 citations

Cellular Senescence

2000 • 743 citations

Regulation of p16^CDKN2 Expression and Its Implications for Cell Immortalization and Senescence

1996 • 713 citations

Telomere Shortening Is Associated with Cell Division in Vitro and in Vivo

1995 • 528 citations

The biology of replicative senescence

1997 • 511 citations

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

1998 • 481 citations

Rethinking Chronic Allograft Nephropathy

1999 • 443 citations

Aging and the kidney.

1996 • 440 citations

Cellular senescence and cancer

1999 • 363 citations

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

1964 • 339 citations

Increased activity of p53 in senescing fibroblasts.

1995 • 303 citations

Alterations in p53 and p16^INK4 Expression and Telomere Length during Spontaneous Immortalization of Li-Fraumeni Syndrome Fibroblasts

1995 • 248 citations

Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation

1998 • 231 citations

Telomere Shortening in Kidneys with Age

2000 • 183 citations

Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

1994 • 177 citations

Reinitiation of DNA Synthesis and Cell Division in Senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies

1998 • 162 citations

Apoptosis and necrosis: Mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line

1998 • 161 citations

Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition

1997 • 160 citations

Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.

1996 • 151 citations

SYNERGISTIC EFFECTS OF CYCLOSPORINE AND RAPAMYCIN IN A CHRONIC NEPHROTOXICITY MODEL1

1996 • 133 citations

Induction of senescence in human malignant glioma cells by p16INK4A

1997 • 131 citations

Changes with age in the human kidney

1982 • 131 citations

CHRONIC CYCLOSPORINE-INDUCED NEPHROPATHY IN THE RAT

1990 • 119 citations

Chronic cyclosporine nephrotoxicity

1998 • 111 citations

Telomere Length in Fibroblasts and Blood Cells from Healthy Centenarians

1999 • 109 citations

Cyclosporine nephropathy: pathophysiology and clinical impact.

1996 • 101 citations

Replicative Senescence of Biliary Epithelial Cells Precedes Bile Duct Loss in Chronic Liver Allograft Rejection

2001 • 100 citations

Cell Senescence and Its Implications for Nephrology

2001 • 99 citations

Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres.

1998 • 90 citations

Nitric oxide mediates cyclosporine-induced apoptosis in cultured renal cells

2000 • 69 citations

Sodium depletion enhances fibrosis and the expression of TGF-β1 and matrix proteins in experimental chronic cyclosporine nephropathy

1997 • 68 citations

FK506-INDUCED KIDNEY TUBULAR CELL INJURY

1992 • 55 citations

Toxicity of ifosfamide, cyclophosphamide and their metabolites in renal tubular cells in culture

1994 • 54 citations

Cyclosporine A-induced cell cycle arrest and cell death in renal epithelial cells

1999 • 47 citations

Effects of Cyclosporin A on the Synthesis, Excretion, and Metabolism of Endothelin in the Rat

1996 • 46 citations

Role of Intrarenal Endothelin 1, Endothelin 3, and Angiotensin II Expression in Chronic Cyclosporin A Nephrotoxicity in Rats

2000 • 45 citations

Apoptosis in human papillomavirus16 E7-, but not E6-immortalized human uroepithelial cells.

1996 • 43 citations

Effect of cyclosporin A on endothelin synthesis by cultured human renal cortical epithelial cells

1993 • 40 citations

Telomerase and cellular lifespan: Ending the debate?

1998 • 38 citations

De novo CD44 expression by proliferating mesangial cells in rat anti-Thy-1 nephritis.

1996 • 38 citations

Cellular Senescence in Telomerase-Expressing Syrian Hamster Embryo Cells

1998 • 37 citations

Primary culture of proximal tubular cells from normal rat kidney as an in vitro model to study mechanisms of nephrotoxicity

1990 • 36 citations

The influence of cell context on the selection pressure for p53 mutation in human cancer

1998 • 34 citations

The Aging Kidney

1985 • 32 citations

QUINACRINE ATTENUATES CYCLOSPORINE-INDUCED NEPHROTOXICITY IN RATS1

1996 • 32 citations

Primary culture of rabbit proximal tubules as a cellular model to study nephrotoxicity of xenobiotics

1993 • 30 citations

Differential actions of cisplatin on renal proximal tubule and inner medullary collecting duct cells.

1993 • 29 citations

Cyclosporin A and vehicle toxicity in primary cultures of rabbit renal proximal tubule cells

1990 • 26 citations

Examination of Telomere Lengths in Muscle Tissue Casts Doubt on Replicative Aging as Cause of Progression in Duchenne Muscular Dystrophy

1997 • 25 citations

Acute cyclosporine A-induced nephrotoxicity: a rabbit model

2000 • 20 citations

STRUCTURE-ACTIVITY RELATIONSHIPS OF CYCLOSPORINES

1989 • 16 citations

Cyclosporine A-induced alterations in magnesium homeostasis in the rat

1999 • 15 citations

Acute Inhibition of Human Renal Tubular Cell Growth by Cyclosporin A

1990 • 11 citations

Cellular senescence: a new marker of kidney function recovery after ischemic injury in rats

2001 • 10 citations

Direct effect of chronic cyclosporine treatment on collagen III mRNA expression and deposition in rat kidneys.

2000 • 5 citations

An Animal Model of Chronic Cyclosporine Nephrotoxicity

1999 • 5 citations