Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells

The Hallmarks of Cancer

2000 • 27,569 citations

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

Tumour-cell invasion and migration: diversity and escape mechanisms

2003 • 3,069 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

Genomic analysis of metastasis reveals an essential role for RhoC

2000 • 1,449 citations

Compensation mechanism in tumor cell migration

2003 • 1,360 citations

Selection of Successive Tumour Lines for Metastasis

1973 • 1,360 citations

RHO–GTPases and cancer

2002 • 1,355 citations

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

2003 • 1,109 citations

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

1998 • 696 citations

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

1996 • 667 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell mov

2001 • 594 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

2000 • 550 citations

Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment

2000 • 545 citations

Differential regulation of cell motility and invasion by FAK

2003 • 531 citations

ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility

2003 • 389 citations

Differential Roles of WAVE1 and WAVE2 in Dorsal and Peripheral Ruffle Formation for Fibroblast Cell Migration

2003 • 311 citations

Activation of the Protein Kinase p38 in the Spindle Assembly Checkpoint and Mitotic Arrest

1998 • 264 citations

Identification of Two Human WAVE/SCAR Homologues as General Actin Regulatory Molecules Which Associate with the Arp2/3 Complex

1999 • 242 citations

WAVE2 is required for directed cell migration and cardiovascular development

2003 • 239 citations

A role for LIM kinase in cancer invasion

2003 • 204 citations

Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice

2003 • 204 citations

Cdc42Hs, but Not Rac1, Inhibits Serum-stimulated Cell Cycle Progression at G1/S through a Mechanism Requiring p38/RK

1997 • 191 citations

WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility

2003 • 186 citations

Rac1 Mediates Type I Collagen-dependent MMP-2 Activation

2001 • 177 citations

Sustained Activation of N-WASP through Phosphorylation Is Essential for Neurite Extension

2002 • 168 citations

Rac Regulates Endothelial Morphogenesis and Capillary Assembly

2002 • 160 citations

EGF stimulates lamellipod extension in metastatic mammary adenocarcinoma cells by an actin-dependent mechanism

1996 • 146 citations

Stromal Cell-Derived Factor-1α Promotes Melanoma Cell Invasion across Basement Membranes Involving Stimulation of Membrane-Type 1 Matrix Metalloproteinase and Rho GTPase Activities

2004 • 138 citations

Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells

2003 • 109 citations

Gelsolin-induced epithelial cell invasion is dependent on Ras-Rac signaling

2002 • 106 citations

Differential localization of WAVE isoforms in filopodia and lamellipodia of the neuronal growth cone

2002 • 93 citations

Spatial and temporal regulation of actin polymerization for cytoskeleton formation through Arp2/3 complex and WASP/WAVE proteins

2002 • 71 citations

Cell shape changes and cytoskeleton reorganization during transendothelial migration of human melanoma cells

1998 • 50 citations

Down-regulation of Glutathione and Bcl-2 Synthesis in Mouse B16 Melanoma Cells Avoids Their Survival during Interaction with the Vascular Endothelium

2003 • 48 citations

Syngeneic Murine Metastasis Models: B16 Melanoma

2003 • 8 citations