Immune mechanisms leading to atopic dermatitis

Atopic Dermatitis

2000 • 4,717 citations

Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial

2001 • 2,461 citations

Anesthesiology

1997 • 2,182 citations

Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP

2002 • 2,037 citations

Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis

2002 • 1,898 citations

Environmental Exposure to Endotoxin and Its Relation to Asthma in School-Age Children

2002 • 1,810 citations

Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey

2001 • 1,488 citations

Allergy and Allergic Diseases

2001 • 1,349 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

Atopic dermatitis and the atopic march

2003 • 1,159 citations

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

2002 • 985 citations

Transplacental Priming of the Human Immune System to Environmental Allergens: Universal Skewing of Initial T Cell Responses Toward the Th2 Cytokine Profile

1998 • 797 citations

CCL27–CCR10 interactions regulate T cell–mediated skin inflammation

2002 • 773 citations

Breastfeeding as prophylaxis against atopic disease: prospective follow-up study until 17 years old

1995 • 731 citations

Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study

2000 • 704 citations

The role of T lymphocytes in the pathogenesis of asthma

2003 • 572 citations

Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity

2001 • 541 citations

Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI).

1992 • 490 citations

Ceramide and cholesterol composition of the skin of patients with atopic dermatitis

1998 • 474 citations

T cell–mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis

2000 • 473 citations

Allergic and nonallergic forms of atopic diseases

2003 • 437 citations

Double-blind controlled trial of effect of housedust-mite allergen avoidance on atopic dermatitis

1996 • 423 citations

Immunomorphological and Ultrastructural Characterization of Langerhans Cells and a Novel, Inflammatory Dendritic Epidermal Cell (IDEC) Population in Lesional Skin of Atopic Eczema

1996 • 404 citations

Gene polymorphism in Netherton and common atopic disease

2001 • 392 citations

Epidermal Langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI.

1992 • 388 citations

Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci

2001 • 386 citations

In vivo expression of IL-12 and IL-13 in atopic dermatitis

1996 • 380 citations

Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes

2002 • 353 citations

Maternal inheritance of atopic IgE responsiveness on chromosome 11 q

1992 • 347 citations

Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis

2002 • 329 citations

Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions

2003 • 308 citations

Keratinocytes from patients with atopic dermatitis and psoriasis show a distinct chemokine production profile in response to T cell–derived cytokines

2001 • 300 citations

Atopy patch tests, together with determination of specific IgE levels, reduce the need for oral food challenges in children with atopic dermatitis

2001 • 298 citations

Biology and clinical relevance of naturally occurring antimicrobial peptides

2002 • 292 citations

Epidemiology, clinical features, and immunology of the “intrinsic” (non‐IgE‐mediated) type of atopic dermatitis (constitutional dermatitis)

2001 • 276 citations

Why are allergies increasing?

2001 • 270 citations

A major susceptibility locus for atopic dermatitis maps to chromosome 3q21

2000 • 266 citations

Fibronectin and fibrinogen contribute to the enhanced binding of Staphylococcus aureus to atopic skin

2001 • 259 citations

Blockade of the EGF Receptor Induces a Deranged Chemokine Expression in Keratinocytes Leading to Enhanced Skin Inflammation

2003 • 257 citations

Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family.

1990 • 225 citations

Mast cells, nerves and neuropeptides in atopic dermatitis and nummular eczema

2003 • 222 citations

Enhanced Expression of Eotaxin and CCR3 in Atopic Dermatitis

1999 • 217 citations

Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions

2000 • 216 citations

Abnormal Expression of Sphingomyelin Acylase in Atopic Dermatitis: An Etiologic Factor for Ceramide Deficiency?

1996 • 209 citations

Expression and Function of the Mannose Receptor CD206 on Epidermal Dendritic Cells in Inflammatory Skin Diseases

2002 • 206 citations

Granulocyte macrophage colony-stimulating factor is overproduced by keratinocytes in atopic dermatitis. Implications for sustained dendritic cell activation in the skin.

1997 • 202 citations

Skin-homing, CLA+ memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern: IgG4 counter-regulation by CLA- memory T cells.

1997 • 196 citations

Evaluating the relevance of aeroallergen sensitization in atopic eczema with the atopy patch test: A randomized, double-blind multicenter study

1999 • 192 citations

Infection in atopic dermatitis

2003 • 191 citations

Induction of atopic dermatitis by inhalation of house dust mite

1996 • 188 citations

Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations

2003 • 170 citations

Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis

2001 • 155 citations

Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation.

1998 • 149 citations

Development of long term tolerance versus sensitisation to environmental allergens during the perinatal period

1997 • 147 citations

Immunoglobulin E Response to Human Proteins in Atopic Patients

1996 • 140 citations

Atopy patch test reactions show a rapid influx of inflammatory dendritic epidermal cells in patients with extrinsic atopic dermatitis and patients with intrinsic atopic dermatitis

2003 • 138 citations

Delayed eosinophil programmed cell death in vitro: A common feature of inhalant allergy and extrinsic and intrinsic atopic dermatitis☆☆☆★★★

1997 • 137 citations

Atopic dermatitis: from the genes to skin lesions

2000 • 136 citations

Molecular Characterization of an Autoallergen, Hom s 1, Identified by Serum IgE from Atopic Dermatitis Patients11Part of this manuscript was previously published in the proceedings of the 21st Symposium of the Collegium Internationale Allergologicum “Allergy – A Disease of Modern Society”, Int Arch Allergy Immunol 113:209–212, 1998

1998 • 135 citations

Atopic Eczema/Dermatitis Syndrome and <i>Malassezia</i>

2002 • 131 citations

Enhanced production of CC-chemokines (RANTES, MCP-1, MIP-1α, MIP-1β, and eotaxin) in patients with atopic dermatitis

2001 • 129 citations

Epicutaneous sensitization with superantigen induces allergic skin inflammation

2003 • 126 citations

Eosinophils and Eosinophil-Associated Cytokines in Allergic Inflammation

1997 • 122 citations

Immune Dysregulation in Atopic Eczema

1992 • 117 citations

The Differential Fate of Cadherins during T-Cell-Induced Keratinocyte Apoptosis Leads to Spongiosis in Eczematous Dermatitis

2001 • 114 citations

Atopy patch test reactions are associated with T lymphocyte‐mediated allergen‐specific immune responses in atopic dermatitis

1999 • 114 citations

Engagement of FcεRI on Human Monocytes Induces the Production of IL-10 and Prevents Their Differentiation in Dendritic Cells

2001 • 112 citations

Skin Manifestations of Food Allergy

2003 • 112 citations

A Second Step of Chemotaxis After Transendothelial Migration: Keratinocytes Undergoing Apoptosis Release IFN-γ-Inducible Protein 10, Monokine Induced by IFN-γ, and IFN-γ-Inducible α-Chemoattractant for T Cell Chemotaxis Toward Epidermis in Atopic Dermatitis

2003 • 112 citations

Levels of circulating CD8+ T lymphocytes, natural killer cells, and eosinophils increase upon acute psychosocial stress in patients with atopic dermatitis

2001 • 111 citations

Calcitonin Gene-Related Peptide Decreases Expression of HLA-DR and CD86 by Human Dendritic Cells and Dampens Dendritic Cell-Driven T Cell-Proliferative Responses Via the Type I Calcitonin Gene-Related Peptide Receptor

2000 • 108 citations

The effect of maternal avoidance of eggs, cow's milk, and fish during lactation on the development of IgE, IgG, and IgA antibodies in infants

1990 • 107 citations

Epidermal barrier in disorders of the skin

1997 • 102 citations

Unraveling the mission of FcϵRI on antigen-presenting cells

2003 • 99 citations

FcεRI Induces the Tryptophan Degradation Pathway Involved in Regulating T Cell Responses

2002 • 98 citations

Clinical and immunologic variables in skin of patients with atopic eczema and either positive or negative atopy patch test reactions

2000 • 97 citations

Phenotyping of epidermal dendritic cells: Clinical applications of a flow cytometric micromethod

1999 • 95 citations

Developing Patterns of T Cell Memory to Environmental Allergens in the First Two Years of Life

1997 • 92 citations

Monocyte Phosphodiesterase Abnormalities and Dysregulation of Lymphocyte Function in Atopic Dermatitis

1995 • 89 citations

Atopic dermatitis: pathogenetic mechanisms

2000 • 89 citations

Positive atopy patch test reactions to Pityrosporumorbiculare in atopic dermatitis patients

2000 • 89 citations

5. Genetics of hypersensitivity

2003 • 84 citations

Current management of atopic dermatitis and interruption of the atopic march

2003 • 84 citations

Neuropeptides and neuroendocrine hormones in ultraviolet radiation-induced immunosuppression

2002 • 80 citations

The ‘Atopy Patch Test’ in Evaluating the Role of Aeroallergens in Atopic Eczema

1997 • 79 citations

Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients

2002 • 77 citations

Phenotyping of epidermal dendritic cells allows the differentiation between extrinsic and intrinsic forms of atopic dermatitis

2000 • 77 citations

Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation

1998 • 75 citations

Role of aeroallergens in atopic eczema: Proof of concept with the atopy patch test

2001 • 74 citations

Competing Functions Encoded in the Allergy-Associated FcϵRIβ Gene

2003 • 67 citations

Neuropeptides: role in inflammatory skin diseases.

1998 • 66 citations

New insights into the role of T cells in atopic dermatitis and allergic contact dermatitis

2001 • 61 citations

ATOPIC DERMATITIS: New insights and opportunities for therapeutic intervention

2001 • 58 citations

Increased plasma eotaxin in atopic dermatitis and acute urticaria in infants and children

2001 • 57 citations

The relevance of maternal immune responses to inhalant allergens to maternal symptoms, passive transfer to the infant, and development of antibodies in the first 2 years of life

2003 • 53 citations

Blood eosinophils from atopic donors express messenger RNA for the α, β, and γ subunits of the high-affinity IgE receptor (FcϵRI) and intracellular, but not cell surface, α subunit protein

2000 • 49 citations

Monocyte Localization of Elevated cAMP Phosphodiesterase Activity in Atopic Dermatitis

1986 • 48 citations

The disturbance of epidermal barrier function in atopy patch test reactions in atopic eczema

1996 • 48 citations

Essential fatty acids in breast milk of atopic mothers: comparison with non-atopic mothers, and effect of borage oil supplementation

2000 • 47 citations

The role of the atopy patch test (APT) in diagnosis of food allergy in infants and children with atopic dermatitis

2001 • 45 citations

The effect of neuropeptides/hormones on Langerhans cells

1999 • 43 citations

A Reducing Microenvironment Leads to the Generation of FcεRIhigh Inflammatory Dendritic Epidermal Cells (IDEC)

2002 • 42 citations

Characterization of IgE–Reactive Autoantigens in Atopic Dermatitis

1999 • 42 citations

Cytokine network and dysregulated apoptosis in atopic dermatitis

2001 • 42 citations

Characterization of a Novel Isoform of α-Nascent Polypeptide-associated Complex as IgE-defined Autoantigen

2002 • 40 citations

Characterization of monocyte subtypes in the allergic form of atopic eczema/dermatitis syndrome

2002 • 39 citations

Asthma: T-bet — A Master Controller?

2002 • 39 citations

Modulation of the atopy patch test reaction by topical corticosteroids and tar

2000 • 39 citations

Atopiform dermatitis: do we need another confusing name for atopic dermatitis?

2002 • 39 citations

Mechanisms of T-cell homing to skin.

2001 • 38 citations

Cell-surface expression of CD25, CD26, and CD30 by allergen-specific T cells is intrinsically different in cow's milk allergy

2002 • 37 citations

Genetic Variants of the Receptors for Thromboxane A2 and IL-4 in Atopic Dermatitis

2002 • 36 citations

Urine eosinophil protein X (EPX) is an in vitro parameter of inflammation in atopic dermatitis of the adult age

2001 • 35 citations

Genetic aspects of atopic allergy

1998 • 32 citations

Pathogenetic Mechanisms of Atopic Dermatitis

2001 • 32 citations

Early events in atopy

2002 • 32 citations

Role of dysregulated apoptosis in atopic dermatitis.

2000 • 30 citations

Association of the human Fc epsilon RI gamma subunit with novel cell surface polypeptides.

1992 • 30 citations

The role of keratinocytes in the pathogenesis of atopic dermatitis

2001 • 28 citations

Reciprocal patterns of allergen‐induced GATA‐3 expression in peripheral blood mononuclear cells from atopics vs. non‐atopics

2002 • 27 citations

Langerhans cell expression of neuropeptide Y and peptide YY

2002 • 27 citations

Mechanisms of FcεRI-IgE-Facilitated Allergen Presentation by Dendritic Cells

1997 • 26 citations

Patch testing with 20% Dermatophagoides pteronyssinus/farinae (Chemotechnique) antigen

2001 • 24 citations

The Early Phase of Epidermal Barrier Regeneration Is Faster in Patients with Atopic Eczema

1997 • 23 citations

Contribution of selectin ligands to eosinophil recruitment into the skin of patients with atopic dermatitis

2002 • 23 citations

Calcitonin gene-related peptide modulates Langerhans cell antigen-presenting function.

1995 • 18 citations

Autoallergy: A Pathogenetic Factor in Atopic Dermatitis?

1999 • 17 citations

T cells and effector mechanisms in the pathogenesis of atopic dermatitis

2002 • 17 citations

Perinatal Events in Relation to Sensitization in the Human

2000 • 13 citations

Pathogenesis of atopic dermatitis (AD) and the role of allergic factors.

2002 • 13 citations