Role of dysregulated apoptosis in atopic dermatitis.

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Diagnostic Features of Atopic Dermatitis

1980 • 4,910 citations

Atopic Dermatitis

2000 • 4,717 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Eosinophilic Inflammation in Asthma

1990 • 2,535 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis..

1994 • 1,105 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

ELAM-1 is an adhesion molecule for skin-homing T cells

1991 • 843 citations

Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis.

1994 • 780 citations

Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects.

1991 • 676 citations

A License to Kill

1996 • 649 citations

Fas and FasL in the homeostatic regulation of immune responses

1995 • 579 citations

Eosinophilia in transgenic mice expressing interleukin 5.

1990 • 579 citations

The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1.

1991 • 557 citations

A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites.

1990 • 512 citations

Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3.

1988 • 490 citations

Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia.

1997 • 474 citations

T cell–mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis

2000 • 473 citations

T cell subsets and their soluble products regulate eosinophilia in allergic and nonallergic asthma.

1991 • 395 citations

Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells.

1993 • 393 citations

Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils

1991 • 299 citations

Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen.

1995 • 291 citations

Skin Homing (Cutaneous Lymphocyte-Associated Antigen-Positive) CD8+ T Cells Respond to Superantigen and Contribute to Eosinophilia and IgE Production in Atopic Dermatitis

1999 • 197 citations

Skin-homing, CLA+ memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern: IgG4 counter-regulation by CLA- memory T cells.

1997 • 196 citations

T Cells and T Cell-Derived Cytokines as Pathogenic Factors in the Nonallergic Form of Atopic Dermatitis

1999 • 177 citations

Inhibition of programmed eosinophil death: a key pathogenic event for eosinophilia?

1995 • 168 citations

Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss

1997 • 150 citations

Expansion of cytokine-producing CD4-CD8- T cells associated with abnormal Fas expression and hypereosinophilia.

1996 • 149 citations

Migration of skin-homing T cells across cytokine-activated human endothelial cell layers involves interaction of the cutaneous lymphocyte-associated antigen (CLA), the very late antigen-4 (VLA-4), and the lymphocyte function-associated antigen-1 (LFA-1).

1995 • 147 citations

Skin-Selective Lymphocyte Homing Mechanisms in the Pathogenesis of Leukemic Cutaneous T-Cell Lymphoma

1993 • 86 citations

Immunopathology of atopic dermatitis

1992 • 62 citations

Alterations induced in normal human skin by in vivo interferon-gamma

1990 • 60 citations

508 Life span of skin homing T cells in atopic dermatitis: Survival in skin, activation induced apoptosis in peripheral blood

2000 • 6 citations