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Blockade of the EGF Receptor Induces a Deranged Chemokine Expression in Keratinocytes Leading to Enhanced Skin Inflammation

Data up to Jan 2025

Published2003
Citations257
References45

Total Citations Per Year

Abstract

References (45)

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor.

2001 • 988 citations

Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor

2002 • 972 citations

Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

2002 • 846 citations

Biochemical and Clinical Implications of the ErbB/HER Signaling Network of Growth Factor Receptors

1999 • 548 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

Involvement of the epidermal growth factor receptor in epithelial repair in asthma

2000 • 506 citations

Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission

2001 • 463 citations

Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability

2002 • 415 citations

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

1998 • 414 citations

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

1991 • 407 citations

Chemokines: agents for the immunotherapy of cancer?

2002 • 402 citations

Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages

1984 • 316 citations

Keratinocytes from patients with atopic dermatitis and psoriasis show a distinct chemokine production profile in response to T cell–derived cytokines

2001 • 300 citations

Altered [125I] Epidermal Growth Factor Binding and Receptor Distribution in Psoriasis

1986 • 289 citations

Evidence That the Peptidylprolyl Isomerase Domain of the hsp90-binding Immunophilin FKBP52 Is Involved in Both Dynein Interaction and Glucocorticoid Receptor Movement to the Nucleus

2001 • 240 citations

Cross-talk between ERK and p38 MAPK Mediates Selective Suppression of Pro-inflammatory Cytokines by Transforming Growth Factor-β

2002 • 234 citations

Membrane lipids, EGF receptors, and intracellular signals colocalize and are polarized in epithelial cells moving directionally in a physiological electric field

2002 • 213 citations

Granulocyte macrophage colony-stimulating factor is overproduced by keratinocytes in atopic dermatitis. Implications for sustained dendritic cell activation in the skin.

1997 • 202 citations

Regulation of Cyclooxygenase-2 by Interferon γ and Transforming Growth Factor α in Normal Human Epidermal Keratinocytes and Squamous Carcinoma Cells

1999 • 191 citations

Differential and Sequential Expression of Multiple Chemokines during Elicitation of Allergic Contact Hypersensitivity

2001 • 178 citations

EGF-Receptor Tyrosine Kinase Inhibition Induces Keratinocyte Growth Arrest and Terminal Differentiation

1997 • 169 citations

Stress-induced Inhibition of ERK1 and ERK2 by Direct Interaction with p38 MAP Kinase

2001 • 163 citations

Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas.

1993 • 153 citations

Epidermal Growth Factor Receptor-dependent Control of Keratinocyte Survival and Bcl-xL Expression through a MEK-dependent Pathway

2001 • 151 citations

Identification and Quantitation of Interferon-γ Producing T Cells in Psoriatic Lesions: Localization to Both CD4+ and CD8+ Subsets

1998 • 134 citations

The Epidermal Growth Factor Receptor Engages Receptor Interacting Protein and Nuclear Factor-κB (NF-κB)-inducing Kinase to Activate NF-κB

2001 • 128 citations

Effector and regulatory T cells in allergic contact dermatitis

2001 • 118 citations

EGF receptor signaling inhibits keratinocyte apoptosis: evidence for mediation by Bcl-XL

1998 • 112 citations

A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases

2001 • 110 citations

Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation In skin organ culture.

1997 • 107 citations

T-cell subpopulations in the development of atopic and contact allergy

2001 • 92 citations

Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells

2002 • 84 citations

Prophylactic Use of Epidermal Growth Factor Reduces Ischemia/Reperfusion Intestinal Damage

2002 • 79 citations

Autocrine Regulation of Membrane Transforming Growth Factor-α Cleavage

1996 • 75 citations

The epidermal growth factor receptor is required to maintain the proliferative population in the basal compartment of epidermal tumors.

2000 • 74 citations

Differential Utilization and Localization of ErbB Receptor Tyrosine Kinases in Skin Compared to Normal and Malignant Keratinocytes

2001 • 73 citations

Redox-sensitive Transactivation of Epidermal Growth Factor Receptor by Tumor Necrosis Factor Confers the NF-κB Activation

2001 • 62 citations

Essential Role of p38 Mitogen-activated Protein Kinase in Contact Hypersensitivity

2002 • 58 citations

TGF-α Is Widely Expressed in Differentiated as well as Hyperproliferative Skin Epithelium

1991 • 56 citations

Cytokine-Induced Expression of Transforming Growth Factor-α and the Epidermal Growth Factor Receptor in Neonatal Skin Explants

1992 • 50 citations

Enhancement of intestinal growth and repair by growth factors

2001 • 36 citations

Dose-Related Protection from Nickel-Induced Lung Injury in Transgenic Mice Expressing Human Transforming Growth Factor- α

2002 • 31 citations

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Blockade of the EGF Receptor Induces a Deranged Chemokine Expression in Keratinocytes… (2003) – American Journal Of Pathology | Metascience Observatory Explorer