Crystal Structure of the Human BRD2 Bromodomain

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

The language of covalent histone modifications

2000 • 8,260 citations

Automated MAD and MIR structure solution

1999 • 3,079 citations

ESPript: analysis of multiple sequence alignments in PostScript.

1999 • 2,820 citations

Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome

1999 • 1,774 citations

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

2002 • 1,749 citations

Histone Acetyltransferases

2001 • 1,745 citations

Maximum-likelihood density modification

2000 • 1,651 citations

Structure and ligand of a histone acetyltransferase bromodomain

1999 • 1,625 citations

Histone and chromatin cross-talk

2003 • 1,187 citations

brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2SWI2

1992 • 951 citations

Structure and Function of a Human TAF _II 250 Double Bromodomain Module

2000 • 808 citations

Bromodomain: an acetyl‐lysine binding domain

2002 • 722 citations

Histone methylation versus histone acetylation: new insights into epigenetic regulation

2001 • 689 citations

The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

2003 • 635 citations

Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation

1996 • 525 citations

The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p

2000 • 508 citations

Cell-free production and stable-isotope labeling of milligram quantities of proteins

1999 • 485 citations

Displacement of sequence-specific transcription factors from mitotic chromatin

1995 • 444 citations

Interaction of the Bovine Papillomavirus E2 Protein with Brd4 Tethers the Viral DNA to Host Mitotic Chromosomes

2004 • 395 citations

The bromodomain: a conserved sequence found in human,Drosophilaand yeast proteins

1992 • 375 citations

Selective Recognition of Acetylated Histones by Bromodomain Proteins Visualized in Living Cells

2004 • 353 citations

Structural Mechanism of the Bromodomain of the Coactivator CBP in p53 Transcriptional Activation

2004 • 307 citations

A Bromodomain Protein, MCAP, Associates with Mitotic Chromosomes and Affects G₂-to-M Transition

2000 • 281 citations

Structural Basis of Lysine-Acetylated HIV-1 Tat Recognition by PCAF Bromodomain

2002 • 230 citations

The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis.

1996 • 228 citations

Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)

2001 • 207 citations

Regulation of Global Acetylation in Mitosis through Loss of Histone Acetyltransferases and Deacetylases from Chromatin

2001 • 206 citations

BRD4 Bromodomain Gene Rearrangement in Aggressive Carcinoma with Translocation t(15;19)

2001 • 203 citations

Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia

2000 • 201 citations

Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain

2000 • 152 citations

Potential energy functions for threading

1996 • 143 citations

A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator.

1996 • 127 citations

Identification and Characterization of BRDT: A Testis-Specific Gene Related to the Bromodomain Genes RING3 andDrosophila fsh

1997 • 105 citations

A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC

1992 • 87 citations

A Role for TBP Dimerization in Preventing Unregulated Gene Expression

1999 • 71 citations

Dimerization of TFIID When Not Bound to DNA

1996 • 68 citations

TFIIA Regulates TBP and TFIID Dimers

1999 • 44 citations

Phylogeny and structure of theRING3 gene

1996 • 39 citations

Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene

1997 • 36 citations

A Novel Mutation Lacking the Bromodomain of the Transcriptional Coactivator p300 in the SiHa Cervical Carcinoma Cell Line

2001 • 34 citations

Retroviral transduction model of mixed lineage leukemia fused to CREB binding protein

2001 • 11 citations

Orientation of HLA-DNA gene and identification of a CpG island-associated gene adjacent to DNA in human major histocompatibility complex class II region

1991 • 10 citations