Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

Structure and ligand of a histone acetyltransferase bromodomain

1999 • 1,625 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

Altered Hox expression and segmental identity in Mll-mutant mice

1995 • 871 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

Regulation of activity of the transcription factor GATA-1 by acetylation

1998 • 686 citations

Acetylation of general transcription factors by histone acetyltransferases

1997 • 588 citations

An Mll–AF9 Fusion Gene Made by Homologous Recombination Causes Acute Leukemia in Chimeric Mice: A Method to Create Fusion Oncogenes

1996 • 534 citations

Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation

1996 • 525 citations

Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal Translocations

1993 • 523 citations

Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP

2000 • 424 citations

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL

1997 • 416 citations

HIV-1 Tat transcriptional activity is regulated by acetylation

1999 • 411 citations

THE POLYCOMB AND TRITHORAX GROUP PROTEINS OF DROSOPHILA: Trans-Regulators of Homeotic Gene Function

1995 • 390 citations

The bromodomain: a conserved sequence found in human,Drosophilaand yeast proteins

1992 • 375 citations

Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling

1998 • 369 citations

Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases

1998 • 345 citations

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

1997 • 323 citations

Acetylation of HMG I(Y) by CBP Turns off IFNβ Expression by Disrupting the Enhanceosome

1998 • 321 citations

MLL, a mammalian trithorax- group gene, functions as a transcriptional maintenance factor in morphogenesis

1998 • 295 citations

An activity gel assay detects a single, catalytically active histone acetyltransferase subunit in Tetrahymena macronuclei.

1995 • 275 citations

The bromodomain: a chromatin-targeting module?

1999 • 270 citations

Adenoviral E1A-Associated Protein p300 Is Involved in Acute Myeloid Leukemia With t(11; 22)(q23; q13)

1997 • 264 citations

Transcriptional Coregulators in Development

1999 • 242 citations

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene.

1994 • 241 citations

The t(11;16)(q23;p13) Translocation in Myelodysplastic Syndrome Fuses the MLL Gene to the CBP Gene

1997 • 240 citations

The Oncogenic Capacity of HRX-ENL Requires the Transcriptional Transactivation Activity of ENL and the DNA Binding Motifs of HRX

1998 • 238 citations

Mammalian Trithorax and Polycomb -group homologues are antagonistic regulators of homeotic development

1999 • 235 citations

All Patients With the T(11; 16)(q23; p13.3) That Involves MLL and CBP Have Treatment-Related Hematologic Disorders

1997 • 219 citations

The Mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis

1999 • 214 citations

Molecular basis of IIq23 rearrangements in hematopoietic malignant proliferations

1995 • 211 citations

Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro

1998 • 195 citations

The Gcn5 bromodomain co-ordinates nucleosome remodelling

2000 • 194 citations

XenopusNF-Y pre-sets chromatin to potentiate p300 and acetylation-responsive transcription from theXenopus hsp70promoterin vivo

1998 • 186 citations

An In Vivo Topoisomerase II Cleavage Site and a DNase I Hypersensitive Site Colocalize Near Exon 9 in the MLLBreakpoint Cluster Region

1998 • 146 citations

Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice

2000 • 141 citations

Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia.

1995 • 140 citations

c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300

2000 • 127 citations

Rearrangements involving chromosome band 11Q23 in acute leukaemia.

1993 • 108 citations

Overexpression of Wild-Type Retinoic Acid Receptor  (RAR) Recapitulates Retinoic Acid-Sensitive Transformation of Primary Myeloid Progenitors by Acute Promyelocytic Leukemia RAR-Fusion Genes

1999 • 94 citations

DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis

2000 • 93 citations

NovelMLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16) (q23;p13) chromosome translocation

1997 • 88 citations

Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro.

1996 • 71 citations

Establishment and characterization of a megakaryoblast cell line with amplification of MLL

1998 • 49 citations

The Polycomb and Trithorax Group Proteins of Drosophila: Trans-Regulators of Homeotic Gene Function

1995 • 25 citations

Adenoviral E1A-Associated Protein p300 Is Involved in Acute Myeloid Leukemia With t(11; 22)(q23; q13)

1997 • 19 citations

An In Vivo Topoisomerase II Cleavage Site and a DNase I Hypersensitive Site Colocalize Near Exon 9 in the MLLBreakpoint Cluster Region

1998 • 19 citations

Novel MLLCBP fusion transcript in therapy‐related chronic myelomonocytic leukemia with a t(11;16) (q23;p13) chromosome translocation

1997 • 3 citations