T Lymphocytes: Ontogeny, Function, and Relevance to Clinical Disorders

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

1984 • 1,262 citations

Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

1984 • 1,239 citations

Histocompatibility-Linked Immune Response Genes

1972 • 1,194 citations

An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

1984 • 1,132 citations

Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule

1986 • 988 citations

Identification of a putative second T-cell receptor

1986 • 980 citations

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

1987 • 949 citations

Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

1983 • 833 citations

Regulation of the Immune Response — Inducer and Suppressor T-Lymphocyte Subsets in Human Beings

1980 • 727 citations

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1984 • 719 citations

Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes

1987 • 676 citations

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 • 669 citations

The Role of the T3/Antigen Receptor Complex in T-Cell Activation

1986 • 627 citations

H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.

1975 • 623 citations

Long-Term Cultures of HTLV-III—Infected T Cells: a Model of Cytopathology of T-Cell Depletion in AIDS

1986 • 537 citations

A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes

1984 • 528 citations

Use of Monoclonal Antibodies to T-Cell Subsets for Immunologic Monitoring and Treatment in Recipients of Renal Allografts

1981 • 511 citations

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

1984 • 506 citations

Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex

1982 • 494 citations

A third type of murine T-cell receptor gene

1984 • 491 citations

A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation

1987 • 483 citations

Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor

1983 • 464 citations

The Structure, Function, and Expression of Interleukin-2 Receptors on Normal and Malignant Lymphocytes

1986 • 460 citations

Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

1984 • 452 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes

1986 • 430 citations

Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain.

1985 • 416 citations

Structure, organization, and somatic rearrangement of T cell gamma genes

1985 • 395 citations

Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes

1984 • 377 citations

Identification of the components of the murine T cell antigen receptor complex

1985 • 333 citations

The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene

1984 • 306 citations

Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein

1985 • 287 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

The Molecular Basis of Communication within the Cell

1985 • 282 citations

The human T cell receptor: Appearance in ontogeny and biochemical relationship of α and β subunits on IL-2 dependent clones and T cell tumors

1983 • 264 citations

Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion.

1987 • 259 citations

T-Cell Receptor Gene Rearrangements as Clinical Markers of Human T-Cell Lymphomas

1985 • 258 citations

Primary structure of human T-cell receptor α-chain

1984 • 245 citations

Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex

1984 • 232 citations

Diversity and structure of genes of the α family of mouse T-cell antigen receptor

1985 • 228 citations

Complexity of human T-cell antigen receptor β-chain constant- and variable-region genes

1984 • 213 citations

Genomic organization of the genes encoding mouse T-cell receptor α-chain

1985 • 202 citations

Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor α-chain

1985 • 201 citations

Deregulation of c- myc by Translocation of the α-Locus of the T-Cell Receptor in T-Cell Leukemias

1986 • 199 citations

Reconstitution after transplantation with T-lymphocyte-depleted HLA haplotype-mismatched bone marrow for severe combined immunodeficiency.

1982 • 190 citations

Therapy of chronic lymphocytic leukemia and cutaneous T-cell lymphoma with T101 monoclonal antibody.

1984 • 175 citations

Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) pathways of human T-cell activation.

1984 • 175 citations

Activation of human thymocytes via the 50KD T11 sheep erythrocyte binding protein induces the expression of interleukin 2 receptors on both T3+ and T3- populations.

1985 • 170 citations

Complexity of the human T lymphocyte-specific cell surface antigen T3.

1982 • 170 citations

Expression of T3 in association with a molecule distinct from the T-cell antigen receptor heterodimer.

1986 • 168 citations

Identification of the Receptor for Antigen and Major Histocompatibility Complex on Human Inducer T Lymphocytes

1983 • 165 citations

A common pathway for T lymphocyte activation involving both the CD3-Ti complex and CD2 sheep erythrocyte receptor determinants.

1986 • 163 citations

The delineation of antigen receptors on human T lymphocytes

1983 • 162 citations

Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex

1986 • 156 citations

Genes encoding the Ti β subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression

1984 • 134 citations

Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia.

1986 • 131 citations

Location of Gene for β Subunit of Human T-Cell Receptor at Band 7q35, a Region Prone to Rearrangements in T Cells

1985 • 121 citations

Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen.

1986 • 121 citations

A unique T-cell receptor complex expressed on human fetal lymphocytes displaying natural-killer-like activity

1986 • 120 citations

A speculative view of the multicomponent nature of T cell antigen recognition

1986 • 117 citations

Spinal cord degeneration in AIDS

1985 • 113 citations

Biosynthesis and molecular nature of the T3 antigen of human T lymphocytes.

1983 • 110 citations

Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction.

1984 • 108 citations

Peptide variability exists within alpha and beta subunits of the T cell receptor for antigen.

1983 • 101 citations

Genes encoding the T-cell receptor alpha and beta subunits are transcribed in an ordered manner during intrathymic ontogeny.

1985 • 99 citations

The T11 glycoprotein is functionally linked to a calcium channel in precursor and mature T-lineage cells.

1986 • 98 citations

Functional and molecular characteristics of t-cell growth factor

1980 • 90 citations

A Murine T Cell Receptor Gene Complex: Isolation, Structure and Rearrangement

1984 • 89 citations

Immunoglobulin-like nature of the α-chain of a human T-cell antigen/MHC receptor

1984 • 83 citations

Specificity of T-cell clones illustrates altered self hypothesis

1981 • 82 citations

Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes.

1987 • 78 citations

T cell receptor alpha chain genes are located on chromosome 14 at 14q11-14q12 in humans.

1985 • 77 citations

Chromosomal Location of Human T-Cell Receptor Gene T _i β

1984 • 54 citations

Identification of a T Helper Cell-Derived Lymphokine That Activates Resting T Lymphocytes

1986 • 52 citations

Functional isotypes are not encoded by the constant region genes of the beta subunit of the T cell receptor for antigen/major histocompatibility complex.

1984 • 49 citations

Homology of Ti α-subunit of a T-cell antigen–MHC receptor with immunoglobulin

1984 • 46 citations

Who needs more?

1987 • 39 citations

Regional location of T cell receptor gene Ti alpha on human chromosome 14.

1985 • 7 citations

Retraction of Data

1986 • 5 citations

Cited By (0)

Loading...