A speculative view of the multicomponent nature of T cell antigen recognition

Somatic generation of antibody diversity

1983 • 3,275 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

1985 • 942 citations

Genetic Basis for Species Vulnerability in the Cheetah

1985 • 878 citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

1983 • 861 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 • 669 citations

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

1984 • 652 citations

H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.

1975 • 623 citations

Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.

1982 • 600 citations

A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes

1984 • 528 citations

Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody.

1982 • 526 citations

Developmental regulation of T-cell receptor gene expression

1985 • 522 citations

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

1981 • 509 citations

A third type of murine T-cell receptor gene

1984 • 491 citations

Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor

1983 • 464 citations

T cell antigen receptors and the immunoglobulin supergene family

1985 • 453 citations

Genes of the Major Histocompatibility Complex of the Mouse

1983 • 445 citations

The Major Histocompatibility Complex of the Mouse

1979 • 423 citations

Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide

1984 • 407 citations

Structure, organization, and somatic rearrangement of T cell gamma genes

1985 • 395 citations

Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes

1984 • 377 citations

H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus.

1975 • 366 citations

Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.

1977 • 357 citations

Fundamental immunology

1984 • 334 citations

The isolation and sequence of the gene encoding T8: A molecule defining functional classes of T lymphocytes

1985 • 325 citations

The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product.

1983 • 325 citations

H-2 antigens of the thymus determinelymphocyte specificity

1978 • 321 citations

Fine specificity of a continuously growing killer cell clone specific for H-Y antigen

1979 • 317 citations

Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens.

1982 • 306 citations

H-2 Dependence of Co-Operation Between T and B Cells in Vivo

1972 • 285 citations

The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments

1985 • 283 citations

Primary structure of human T-cell receptor α-chain

1984 • 245 citations

Cell Interactions Between Histoincompatible T and B Lymphocytes. The H-2 Gene Complex Determines Successful Physiologic Lymphocyte Interactions

1973 • 241 citations

Structure, expression and divergence of T-cell receptor β-chain variable regions

1984 • 237 citations

Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.

1981 • 234 citations

Diversity and structure of genes of the α family of mouse T-cell antigen receptor

1985 • 228 citations

Structure and expression of a mouse major histocompatibility antigen gene, H-2Ld.

1982 • 223 citations

The mouse T cell receptor: Structural heterogeneity of molecules of normal T cells defined by Xenoantiserum

1983 • 217 citations

Unusual organization and diversity of T-cell receptor a-chain genes

1985 • 212 citations

The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: Identification of constant and variable peptides

1983 • 209 citations

Genomic organization of the genes encoding mouse T-cell receptor α-chain

1985 • 202 citations

The T cell receptor: the α and β chains define idiotype, and antigen and MHC specificity

1985 • 198 citations

T-Cell Receptor β-Chain Expression: Dependence on Relatively Few Variable Region Genes

1985 • 197 citations

CELL INTERACTIONS BETWEEN HISTOINCOMPATIBLE T AND B LYMPHOCYTES

1973 • 190 citations

Limited diversity of the rearranged T-cell γ gene

1985 • 185 citations

BIOCHEMISTRY OF THE GENE PRODUCTS FROM MURINE MHC MUTANTS

1980 • 182 citations

Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes

1985 • 172 citations

High frequency and nonrandom distribution of alloreactivity in T cell clones selected for recognition of foreign antigen in association with self class II molecules.

1986 • 158 citations

T-cell specificity for H–2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells

1980 • 153 citations

Direct evidence for chromosomal inversion during T-cell receptor β-gene rearrangements

1986 • 151 citations

A program for prediction of protein secondary structure from nucleotide sequence data: application to histocompatibility antigens

1984 • 150 citations

Early cellular events in a systemic graft-vs.-host reaction. II. Autoradiographic estimates of the frequency of donor lymphocytes which respond to each Ag-B-determined antigenic complex.

1975 • 148 citations

The role of L3T4 in recognition of Ia by a cytotoxic, H-2Dd-specific T cell hybridoma.

1984 • 146 citations

Molecular Genetics of the T Cell-Receptor Beta Chain

1985 • 140 citations

Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA

1985 • 135 citations

Helper T cells recognize antigen and macrophage surface components simultaneously

1976 • 131 citations

Variability and repertoire size of T-cell receptor Vα gene segments

1985 • 131 citations

Nucleotide Sequence of a Light Chain Gene of the Mouse I-A Subregion: Aβ ^d

1983 • 127 citations

Rearranged β t cell receptor genes in a helper t cell clone specific for lysozyme: No correlation between Vβ and MHC restriction

1985 • 120 citations

Structure of Class I Major Histocompatibility Antigens

1983 • 107 citations

Hybrid H-2 histocompatibility gene products assign domains recognized by alloreactive T cells.

1983 • 104 citations

Intrathymic presentation of circulating non-major histocompatibility complex antigens

1984 • 102 citations

Peptide variability exists within alpha and beta subunits of the T cell receptor for antigen.

1983 • 101 citations

Genetics and Expression of Mouse Ia Antigens

1985 • 99 citations

Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered-self hypothesis.

1982 • 95 citations

Inhibition of T cell-mediated cytolysis by monoclonal antibodies directed against Lyt-2: heterogeneity of inhibition at the clonal level.

1981 • 94 citations

Allospecific and virus-specific cytolytic T lymphocytes are restricted to the N or C1 domain of H-2 antigens expressed on L cells after DNA-mediated gene transfer.

1983 • 92 citations

Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein

1985 • 86 citations

Differentiation and cell division in the mammalian thymus

1985 • 84 citations

A molecular basis for thymic selection: regulation of T11 induced thymocyte expansion by the T3-Ti antigen/MHC receptor pathway

1985 • 84 citations

Adaptive differentiation of murine lymphocytes. I. Both T and B lymphocytes differentiating in F1 transplanted to parental chimeras manifest preferential cooperative activity for partner lymphocytes derived from the same parental type corresponding to the chimeric host.

1978 • 84 citations

Antigen‐Specific, Proliferating T Lymphocyte Clones. Methodology, Specificity, MHC Restriction and Alloreactivity

1981 • 82 citations

Recognition of conformational determinants on H–2 by cytolytic T lymphocytes

1982 • 82 citations

Participation of the major histocompatibility complex in antibody recognition of viral antigens expressed on infected cells.

1982 • 81 citations

Identical Vβ T-cell receptor genes used in alloreactive cytotoxic and antigen plus I–A specific helper T cells

1985 • 79 citations

The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions

1985 • 79 citations

Xenogeneic human anti-mouse T cell responses are due to the activity of the same functional T cell subsets responsible for allospecific and major histocompatibility complex-restricted responses.

1983 • 77 citations

Thymic cytotoxic T lymphocytes are primed in vivo to minor histocompatibility antigens.

1984 • 76 citations

Vβ gene polymorphism and a major polyclonal T cell receptor idiotype

1985 • 75 citations

H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras.

1976 • 73 citations

Possible involvement of the OKT4 molecule in T-cell recognition of class II HLA antigens.

1983 • 71 citations

The differentiation of cytotoxic T cells in vitro. II. Amplifying factor(s) produced in primary mixed lymphocyte cultures against K/D stimuli require the presence of Lyt 2+ cells but not Lyt 1+ cells.

1980 • 60 citations

Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells.

1982 • 58 citations

T-cell recognition of a chimaeric class II/class I MHC molecule and the role of L3T4

1985 • 55 citations

Influence of the major histocompatibility complex on lymphocyte interactions in antibody formation

1978 • 48 citations

T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells.

1978 • 45 citations

A one and a half receptor model for MHC-restricted antigen recognition by T lymphocytes

1985 • 41 citations

Primary anti-viral cytotoxic T-cell responses in semiallogeneic chimeras are not absolutely restricted to host H-2 type.

1979 • 39 citations

Cytotoxic T lymphocytes recognize determinants on the BALB/c-H-2Ld molecule controlled by ?1 and ?2 but not ?3 external domains

1984 • 37 citations

Characterization of antigen-specific, Ia-restricted, L3T4+ cytolytic T lymphocytes and assessment of thymic influence on their self specificity.

1985 • 34 citations

Selection of restriction specificities of virus-specific cytotoxic T cells in the thymus: no evidence for a crucial role of antigen-presenting cells.

1982 • 33 citations

Differences in the MHC-restricted self-recognition repertoire of intra-thymic and extra-thymic cytotoxic T lymphocyte precursors.

1983 • 32 citations

H-2 restriction as a consequence of intentional priming. Frequency analysis of alloantigen-restricted, trinitrophenyl-specific cytotoxic T lymphocyte precursors within thymocytes of normal mice.

1981 • 31 citations

On the anomalous nature of the major histocompatibility complex in Syrian hamsters, Hm-1.

1983 • 30 citations

The role of T8 in the cytotoxic activity of cloned cytotoxic T lymphocyte lines specific for class II and class I major histocompatibility complex antigens.

1985 • 29 citations

The predicted structure of the Ia beta 1 domain. A hypothesis for the structural basis of major histocompatibility complex-restricted T-cell recognition of antigens.

1985 • 25 citations

Homogeneity of antibodies produced by clones in vitro

1973 • 24 citations

Patterns of virus-immune T-cell responsiveness. Comparison of (H-2(k) x H-2(b)) {arrow} H-2(b) Radiation Chimeras and negatively selected H-2(b) lymphocytes

1979 • 23 citations

Frequency analysis of cytotoxic T lymphocyte precursors in chimeric mice. Evidence for intrathymic maturation of clonally distinct self-major histocompatibility complex- and allo-major histocompatiblilty complex-restricted virus-specific T cells.

1981 • 21 citations

The Association between Class-I Transplantation Antigens and an Adenovirus Membrane Protein

1984 • 21 citations

The Predicted Structure of the Iaß₁, Domain

1985 • 21 citations

Analysis of heterogeneous dissociation kinetics in polyclonal populations of rabbit anti-fluorescyl-IgG antibodies

1983 • 19 citations

T cells function via restricted recognition of antigen, not antigen-restricted recognition

1985 • 17 citations

Major histocompatibility complex-restricted self-recognition in responses to trinitrophenyl-ficoll. Adaptive differentiation and self-recognition by B cells.

1982 • 17 citations

Alloreactivity of Antigen-Specific T Cell Clones

1982 • 15 citations

Thymic education

1981 • 14 citations

Lymphoid function in F1 leads to parent chimeras: lack of evidence for adaptive differentiation of B cells or antigen-presenting cells.

1979 • 12 citations

Allogeneic and associative recognition determinants of H-2 molecules.

1983 • 11 citations

Molecules at work on the T-cell surface

1985 • 10 citations