Disease model: hyperinsulinemia and insulin resistance

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

1990 • 1,226 citations

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

2000 • 1,213 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

2000 • 733 citations

The IRS-signalling system: A network of docking proteins that mediate insulin action

1998 • 693 citations

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1996 • 596 citations

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

1997 • 549 citations

Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

1999 • 526 citations

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1998 • 523 citations

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

1995 • 478 citations

GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes

1997 • 359 citations

Insulin Signalling and Insulin Actions in the Muscles and Livers of Insulin-Resistant, Insulin Receptor Substrate 1-Deficient Mice

1996 • 289 citations

Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice

1999 • 239 citations

Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.

1998 • 230 citations

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

2000 • 220 citations

Insulin Receptor Substrate 3 Is Not Essential for Growth or Glucose Homeostasis

1999 • 191 citations

Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.

1997 • 144 citations

Resistance to Insulin-Stimulated Glucose Uptake in Adipocytes Isolated From Spontaneously Hypertensive Rats

1989 • 126 citations

Insulin Receptor Substrate-2 Is Not Necessary for Insulin- and Exercise-stimulated Glucose Transport in Skeletal Muscle

1999 • 106 citations

Muscle-specific transgenic complementation of GLUT4-deficient mice. Effects on glucose but not lipid metabolism.

1997 • 67 citations

Prevention of insulin resistance and diabetes in mice heterozygous for GLUT4 ablation by transgenic complementation of GLUT4 in skeletal muscle.

1999 • 61 citations

Increased Risk Factors for Coronary Artery Disease in Japanese Subjects With Hyperinsulinemia or Glucose Intolerance

1994 • 54 citations

Resistance to insulin-stimulated glucose uptake in adipocytes isolated from spontaneously hypertensive rats

1989 • 44 citations