Rapid Induction of Cell Death by Selenium-compromised Thioredoxin Reductase 1 but Not by the Fully Active Enzyme Containing Selenocysteine

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

2001 • 4,399 citations

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordberg, 2001, Karolinska Institute, Stockholm, ISBN 91-631-1064-4.

2001 • 2,603 citations

Physiological functions of thioredoxin and thioredoxin reductase

2000 • 2,440 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals

2001 • 642 citations

Current Protocols in Toxicology

2001 • 549 citations

Human Placenta Thioredoxin Reductase

1998 • 519 citations

Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

2000 • 498 citations

Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?

2002 • 490 citations

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.

1996 • 471 citations

Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation

1999 • 433 citations

Knowing when not to stop: selenocysteine incorporation in eukaryotes

1996 • 433 citations

Essential Role of Selenium in the Catalytic Activities of Mammalian Thioredoxin Reductase Revealed by Characterization of Recombinant Enzymes with Selenocysteine Mutations

2000 • 418 citations

Thioredoxin reductase as a pathophysiological factor and drug target

2000 • 382 citations

Thioredoxin Peroxidase Is a Novel Inhibitor of Apoptosis with a Mechanism Distinct from That of Bcl-2

1997 • 372 citations

Three-dimensional structure of a mammalian thioredoxin reductase: Implications for mechanism and evolution of a selenocysteine-dependent enzyme

2001 • 331 citations

Redox Regulation of Cell Signaling by Selenocysteine in Mammalian Thioredoxin Reductases

1999 • 327 citations

Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.

1996 • 309 citations

Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems

2001 • 306 citations

Rat and Calf Thioredoxin Reductase Are Homologous to Glutathione Reductase with a Carboxyl-terminal Elongation Containing a Conserved Catalytically Active Penultimate Selenocysteine Residue

1998 • 261 citations

Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin

1999 • 237 citations

High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA , selB and selC genes 1 1Edited by M. Gottesman

1999 • 236 citations

The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

1997 • 227 citations

Intracellular Delivery of Proteins with a New Lipid-mediated Delivery System

2001 • 215 citations

Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity.

1996 • 203 citations

Current Protocols in Toxicology

2001 • 202 citations

Mammalian Thioredoxin Reductase Is Irreversibly Inhibited by Dinitrohalobenzenes by Alkylation of Both the Redox Active Selenocysteine and Its Neighboring Cysteine Residue

1998 • 199 citations

Dueling Activities of AIF in Cell Death versus Survival

2002 • 186 citations

Microinjection of Cathepsin D Induces Caspase-Dependent Apoptosis in Fibroblasts

2002 • 186 citations

1-Chloro-2,4-dinitrobenzene Is an Irreversible Inhibitor of Human Thioredoxin Reductase

1995 • 185 citations

Human mitochondrial thioredoxin reductase

1999 • 178 citations

Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis -diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex

2001 • 176 citations

Electrophilic Prostaglandins and Lipid Aldehydes Repress Redox-sensitive Transcription Factors p53 and Hypoxia-inducible Factor by Impairing the Selenoprotein Thioredoxin Reductase

2003 • 164 citations

Regulation of Human Thioredoxin Reductase Expression and Activity by 3′-Untranslated Region Selenocysteine Insertion Sequence and mRNA Instability Elements

1999 • 108 citations

Thioredoxin Reductase Mediates Cell Death Effects of the Combination of Beta Interferon and Retinoic Acid

1998 • 82 citations

Mechanism-based inhibition of thioredoxin reductase by antitumor quinoid compounds

1992 • 64 citations

Functional expression of rat thioredoxin reductase: selenocysteine insertion sequence element is essential for the active enzyme

1999 • 57 citations

Studies on the Mechanisms and Kinetics of Apoptosis Induced by Microinjection of Cytochrome c in Rat Kidney Tubule Epithelial Cells (NRK-52E)

2000 • 51 citations

Inhibition of cellular thioredoxin reductase by diaziquone and doxorubicin. Relationship to the inhibition of cell proliferation and decreased ribonucleotide reductase activity.

1992 • 51 citations

Regulation of Interferon and Retinoic Acid-induced Cell Death Activation through Thioredoxin Reductase

2001 • 42 citations

Modulation of p53 dependent gene expression and cell death through thioredoxin-thioredoxin reductase by the Interferon-Retinoid combination

2001 • 38 citations

Monitoring Antisense Oligodeoxynucleotide Activity in Hematopoietic Cells

1999 • 35 citations

The interferon-β and tamoxifen combination induces apoptosis using thioredoxin reductase

2000 • 29 citations

Thioredoxin participates in a cell death pathway induced by interferon and retinoid combination

2001 • 28 citations

Mutational Analysis of Human Thioredoxin Reductase 1

2002 • 22 citations

Pinocytic loading of cytochrome c into intact cells specifically induces caspase-dependent permeabilization of mitochondria: evidence for a cytochrome c feedback loop

2001 • 17 citations

Thioredoxin reductase plays a critical role in IFN retinoid-mediated tumor-growth control in vivo.

2002 • 14 citations

Efficiency of Selenocysteine Incorporation in Human Thioredoxin Reductase

2000 • 14 citations