Regulation of Human Thioredoxin Reductase Expression and Activity by 3′-Untranslated Region Selenocysteine Insertion Sequence and mRNA Instability Elements

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

1996 • 2,404 citations

AU-rich elements: characterization and importance in mRNA degradation

1995 • 1,936 citations

Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin

1996 • 1,807 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

The Thyroid and Its Diseases

1964 • 710 citations

Recognition of UGA as a selenocysteine codon in Type I deiodinase requires sequences in the 3′ untranslated region

1991 • 642 citations

Rat liver thioredoxin and thioredoxin reductase: purification and characterization

1982 • 610 citations

Mice Deficient in Cellular Glutathione Peroxidase Develop Normally and Show No Increased Sensitivity to Hyperoxia

1997 • 558 citations

Study of Prediagnostic Selenium Level in Toenails and the Risk of Advanced Prostate Cancer

1998 • 554 citations

A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity.

1996 • 540 citations

Early Embryonic Lethality Caused by Targeted Disruption of the Mouse Thioredoxin Gene

1996 • 529 citations

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

1993 • 490 citations

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.

1996 • 471 citations

Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons.

1993 • 429 citations

Modulation of the Fate of Cytoplasmic mRNA by AU-Rich Elements: Key Sequence Features Controlling mRNA Deadenylation and Decay

1997 • 352 citations

Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene ( Trsp )

1997 • 329 citations

Molecular Cloning and Characterization of a Mitochondrial Selenocysteine-containing Thioredoxin Reductase from Rat Liver

1999 • 277 citations

Rat and Calf Thioredoxin Reductase Are Homologous to Glutathione Reductase with a Carboxyl-terminal Elongation Containing a Conserved Catalytically Active Penultimate Selenocysteine Residue

1998 • 261 citations

Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo.

1997 • 244 citations

Catalytic properties of an Escherichia coli formate dehydrogenase mutant in which sulfur replaces selenium.

1991 • 231 citations

Cloning and sequencing of a human thioredoxin reductase

1995 • 211 citations

Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase

1991 • 200 citations

Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells.

1996 • 161 citations

Contrasting Patterns of Regulation of the Antioxidant Selenoproteins, Thioredoxin Reductase, and Glutathione Peroxidase, in Cancer Cells

1998 • 121 citations

Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation

1992 • 113 citations

Cloning, sequencing and functional expression of a novel human thioredoxin reductase

1999 • 113 citations

Human transcription factor IIIC (TFIIIC)

1989 • 110 citations

Selenocysteine insertion or termination: factors affecting UGA codon fate and complementary anticodon:codon mutations

1994 • 109 citations

Human thioredoxin reductase from HeLa cells: Selective alkylation of selenocysteine in the protein inhibits enzyme activity and reduction with NADPH influences affinity to heparin

1998 • 100 citations

Purification of human thioredoxin reductase: Properties and characterization by absorption and circular dichroism spectroscopy

1993 • 96 citations

Selenocysteine incorporation in eukaryotes: insights into mechanism and efficiency from sequence, structure, and spacing proximity studies of the type 1 deiodinase SECIS element.

1996 • 85 citations

Studies of the Hormonal Regulation of Type 2 5′-Iodothyronine Deiodinase Messenger Ribonucleic Acid in Pituitary Tumor Cells Using Semiquantitative Reverse Transcription-Polymerase Chain Reaction**This work was supported by NIH Grant DK-36256.

1998 • 77 citations

Role of the 3′ untranslated region in the regulation of cytosolic glutathione peroxidase and phospholipid-hydroperoxide glutathione peroxidase gene expression by selenium supply

1996 • 76 citations

The 3′-Untranslated Region of Human Type 2 Iodothyronine Deiodinase mRNA Contains a Functional Selenocysteine Insertion Sequence Element

1998 • 74 citations

Selenium and the thioredoxin redox system: effects on cell growth and death.

1997 • 71 citations

Fetal mouse selenophosphate synthetase 2 (SPS2): Characterization of the cysteine mutant form overproduced in a baculovirus–insect cell system

1997 • 68 citations

Mechanism-based inhibition of thioredoxin reductase by antitumor quinoid compounds

1992 • 64 citations

A 3' truncation of MYC caused by chromosomal translocation in a human T-cell leukemia increases mRNA stability.

1990 • 63 citations

The Thyroid and its Diseases

1996 • 54 citations

Inhibition of cellular thioredoxin reductase by diaziquone and doxorubicin. Relationship to the inhibition of cell proliferation and decreased ribonucleotide reductase activity.

1992 • 51 citations

Functionality of mutations at conserved nucleotides in eukaryotic SECIS elements is determined by the identity of a single nonconserved nucleotide.

1998 • 51 citations