Endoproteolytic processing of a farnesylated peptide in vitro.

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

p21ras is modified by a farnesyl isoprenoid.

1989 • 847 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Proteolytic enzymes; a practical approach

1991 • 786 citations

A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis

1990 • 710 citations

Sequence dependence of protein isoprenylation

1991 • 580 citations

Genetic and Pharmacological Suppression of Oncogenic Mutations in RAS Genes of Yeast and Humans

1989 • 535 citations

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

1989 • 462 citations

Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells.

1989 • 443 citations

Glycosylation and processing of prepro-α-factor through the yeast secretory pathway

1984 • 410 citations

Farnesylated γ-subunit of photoreceptor G protein indispensable for GTP-binding

1990 • 389 citations

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.

1988 • 384 citations

Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component.

1988 • 373 citations

Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit

1991 • 371 citations

Human Lamin B Contains a Farnesylated Cysteine Residue

1989 • 324 citations

Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes.

1991 • 317 citations

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase.

1991 • 312 citations

Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B).

1991 • 291 citations

RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor

1986 • 259 citations

Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini.

1990 • 230 citations

The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins.

1991 • 230 citations

Three proteolytic systems in the yeast saccharomyces cerevisiae

1991 • 228 citations

The gamma subunit of transducin is farnesylated.

1990 • 187 citations

Modification of nuclear lamin proteins by a mevalonic acid derivative occurs in reticulocyte lysates and requires the cysteine residue of the C-terminal CXXM motif.

1989 • 183 citations

Enzymatic Coupling of Cholesterol Intermediates to a Mating Pheromone Precursor and to the Ras Protein

1990 • 175 citations

Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product.

1991 • 148 citations

Identification and preliminary characterization of protein-cysteine farnesyltransferase.

1990 • 138 citations

Common Modifications of Trimeric G Proteins and ras Protein: Involvement of Polyisoprenylation

1990 • 122 citations

Significance of C-terminal cysteine modifications to the biological activity of the Saccharomyces cerevisiae a-factor mating pheromone.

1991 • 116 citations

Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae.

1990 • 115 citations

Characterization of an inhibitory metal binding site in carboxypeptidase A

1991 • 111 citations

Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.

1990 • 109 citations

RAS2 protein of Saccharomyces cerevisiae is methyl-esterified at its carboxyl terminus

1989 • 92 citations

Amino acid sequences of a-factor mating peptides from Saccharomyces cerevisiae.

1987 • 78 citations

Saccharomyces cerevisiae STE14 gene is required for COOH-terminal methylation of a-factor mating pheromone

1990 • 65 citations

RAS2 protein of Saccharomyces cerevisiae undergoes removal of methionine at N terminus and removal of three amino acids at C terminus.

1990 • 59 citations

[29] The protein carboxylmethyltransferase involved in Escherichia coli and Salmonella typhimurium chemotaxis

1984 • 55 citations

Enzymatic Methylation of 23-29-kDa Bovine Retinal Rod Outer Segment Membrane Proteins

1989 • 47 citations

Mechanism of inhibition of human neutrophil collagenase by Gold(I) chrysotherapeutic compounds

1989 • 41 citations

Significance of C-Terminal Cysteine Modifications to the Biological Activity of the Saccharomyces cerevisiae a-Factor Mating Pheromone

1991 • 35 citations

Famesyl Cysteine C-Terminal Methyltransferase Activity Is Dependent upon the STE14 Gene Product in Saccharomyces cerevisiae

1990 • 26 citations

Total in vitro maturation of the Saccharomyces cerevisiaea-factor lipopeptide mating pheromone

1990 • 25 citations