Nutritional and medical importance of gamma-linolenic acid

Free radicals in biology and medicine

1991 • 17,840 citations

EFFECTS OF CHANGES IN FAT, FISH, AND FIBRE INTAKES ON DEATH AND MYOCARDIAL REINFARCTION: DIET AND REINFARCTION TRIAL (DART)

1989 • 2,639 citations

Omega-3 fatty acids in health and disease and in growth and development

1991 • 2,179 citations

Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review.

1989 • 1,152 citations

Fatty acid composition of the plasma lipids in Greenland Eskimos

1975 • 883 citations

Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974.

1980 • 865 citations

Cancer Research: Some Forward Steps

1965 • 733 citations

Epidemiological Studies in the Upernavik District, Greenland

1980 • 691 citations

Hypertriglyceridaemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes

1989 • 622 citations

The Essentiality Of N-3 Fatty Acids For The Development And Function Of The Retina And Brain

1988 • 621 citations

Nutritional and hormonal factors influencing desaturation of essential fatty acids

1981 • 557 citations

Differential oxidation of saturated and unsaturated fatty acids in vivo in the rat

1987 • 552 citations

Dietary Fat and the Risk of Breast Cancer

1987 • 536 citations

Diabets in identical twins

1972 • 433 citations

Free radicals in biology and medicine

1985 • 416 citations

Human absorption of fish oil fatty acids as triacylglycerols, free acids, or ethyl esters

1988 • 347 citations

Biochemistry of essential fatty acids

1981 • 333 citations

Polyunsaturated Fatty Acid-Induced Cytotoxicity Against Tumor Cells and Its Relationship to Lipid Peroxidation

1988 • 290 citations

ORAL EVENING-PRIMROSE-SEED OIL IMPROVES ATOPIC ECZEMA

1982 • 277 citations

Fatty acid composition of human colostrum and mature breast milk

1981 • 266 citations

Essential fatty acids and immune response

1989 • 265 citations

Effect of Prostaglandin E1 on Adjuvant Arthritis

1971 • 264 citations

Serum fatty acids, apolipoproteins, selenium and vitamin antioxidants and the risk of death from coronary artery disease

1985 • 262 citations

Newer Concepts of Atopic Dermatitis

1977 • 259 citations

Effect of sex and age on fatty acid composition of human serum lipids

1979 • 253 citations

Changing patterns of human milk lipids in the course of the lactation and during the day

1983 • 253 citations

Fatty-acid composition of serum lipids predicts myocardial infarction.

1982 • 250 citations

Essential Fatty Acids in Infant Nutrition

1958 • 230 citations

Fatty acids in plasma and red cell membranes in normal humans

1983 • 224 citations

Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a double blind placebo controlled study.

1988 • 218 citations

AN APPROACH TO FREE RADICALS

1983 • 210 citations

Essential fatty acids in the plasma phospholipids of patients with atopic eczema

1984 • 206 citations

Impact of cardiovascular risk factors on coronary heart disease and mortality among middle aged diabetic men: a general population study.

1989 • 198 citations

Meta-analysis of placebo-controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Relationship between plasma essential fatty acid changes and clinical response

1989 • 197 citations

Nutritional and Pharmacological Factors in Eicosanoid Biology

2009 • 191 citations

Diet, Nutrition, and Cancer A Critical Evaluation

1985 • 189 citations

Lipid Metabolism in Mammals

1977 • 184 citations

Nutrition and Biochemistry of Trans and Positional Fatty Acid Isomers in Hydrogenated Oils

1984 • 182 citations

ADIPOSE TISSUE AND PLATELET FATTY ACIDS AND CORONARY HEART DISEASE IN SCOTTISH MEN

1984 • 178 citations

Reduced levels of prostaglandin precursors in the blood of atopic patients: Defective delta-6-desaturase function as a biochemical basis for atopy

1982 • 177 citations

Linoleic acid content in adipose tissue and coronary heart disease.

1986 • 173 citations

Enteral absorption in man of eicosapentaenoic acid in different chemical forms

1987 • 173 citations

Gammar linolenic acid—occurrence and physical and chemical properties

1992 • 166 citations

Enzyme deletions and essential fatty acid metabolism in cultured cells.

1975 • 158 citations

Omega-6 essential fatty acids. Pathophysiology and roles in clinical medicine

1990 • 156 citations

Isomeric trans fatty acids in the U.S. diet.

1990 • 156 citations

Effect of ethanol administration on fatty acid desaturation

1980 • 152 citations

Effect of high doses of essential fatty acids on the postviral fatigue syndrome

1990 • 147 citations

CLINICAL EXPERIENCE OF DRUG TREATMENTS FOR MASTALGIA

1985 • 147 citations

Altered fatty acid desaturation and microsomal fatty acid composition in the streptozotocin diabetic rat

1980 • 145 citations

Requirements of the Female Rat for Linoleic and Linolenic Acids

1968 • 144 citations

Low prevalences of coronary heart disease (CHD), psoriasis, asthma and rheumatoid arthritis in Eskimos: Are they caused by high dietary intake of eicosapentaenoic acid (EPA), a genetic variation of essential fatty acid (EFA) metabolism or a combination of both?

1987 • 142 citations

Suppression of interleukin 2-dependent human T cell growth in vitro by prostaglandin E (PGE) and their precursor fatty acids. Evidence for a PGE-independent mechanism of inhibition by the fatty acids.

1990 • 139 citations

Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins

1987 • 137 citations

Prostaglandin E₁ treatment of NZB/NZW mice

1977 • 137 citations

Interaction of Zinc and Essential Fatty Acids in the Rat

1979 • 136 citations

Absorption of eicosapentaenoic acid and docosahexaenoic acid from fish oil triacylglycerols or fish oil ethyl esters co-ingested with a high-fat meal

1988 • 135 citations

Polyunsaturated fatty acids augment free radical generation in tumor cells in vitro

1987 • 134 citations

Atopic eczema unresponsive to evening primrose oil (linoleic and γ-linolenic acids)

1985 • 134 citations

Prostaglandin E precursor fatty acids inhibit human IL-2 production by a prostaglandin E-independent mechanism

1990 • 134 citations

Fish oil feeding results in an enhancement of cholesterol-induced atherosclerosis in rabbits

1987 • 133 citations

How do polyunsaturated fatty acids lower plasma cholesterol levels?

1983 • 133 citations

The metabolism of dihomo‐γ‐linolenic acid in man

1979 • 132 citations

THYROID CANCER AND THERAPY WITH 131I

1976 • 130 citations

Absorption and transport of fat in mammals with emphasis on n−3 polyunsaturated fatty acids

1988 • 127 citations

Effects of dietary fat and dose level of 7,12-dimethylbenz(alpha)-anthracene on mammary tumor incidence in rats.

1970 • 126 citations

Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat

1985 • 125 citations

The role of essential fatty acids and prostaglandins in the premenstrual syndrome.

1983 • 124 citations

Depression of microsomal desaturation of linoleictoy-linolenicacid in the alloxan-diabetic rat

1966 • 123 citations

Fatty Acid Compositions of Serum Lipids, Erythrocytes, and Platelets in Insulin-Dependent Diabetic Women*

1985 • 121 citations

The Effect of γ‐Linolenic Acid on Human Diabetic Peripheral Neuropathy: A Double‐blind Placebo‐controlled Trial

1990 • 117 citations

Reduced arachidonate in serum phospholipids and cholesteryl esters associated with vegetarian diets in humans

1990 • 116 citations

Investigation of functions of essential fatty acids in the skin

1977 • 114 citations

Lipid Peroxidation and Lipid Antioxidants in Normal and Tumor Cells

1984 • 110 citations

Requirements of Newborn Infants for Long Chain Polyunsaturated Fatty Acids

1989 • 109 citations

Effect of dietary supplementation with n-3 fatty acids on clinical manifestations of psoriasis

1988 • 108 citations

The regulation of prostaglandin biosynthesis: Negative feedback mechanisms and the selective control of formation of 1 and 2 series prostaglandins: Relevance to inflammation and immunity

1980 • 108 citations

Drug Treatments for Mastalgia: 17 Years Experience in the Cardiff Mastalgia Clinic

1992 • 108 citations

Ingestion of Fish Oil or a Derived n-3 Fatty Acid Concentrate Containing Eicosapentaenoic Acid (EPA) Affects Fatty Acid Compositions of Individual Phospholipids of Rat Brain, Sciatic Nerve and Retina

1987 • 105 citations

Suppression of chronic inflammation by evening primrose oil

1981 • 105 citations

n‐6 and n‐3 fatty acids during early human development

1989 • 104 citations

EFFECT OF A LOW-FAT HIGH-CARBOHYDRATE DIET ON SYMPTOMS OF CYCLICAL MASTOPATHY

1988 • 103 citations

Growth-related lipid peroxidation in tumour microsomal membranes and mitochondria

1979 • 102 citations

Dihomo-γ-linolenate suppresses platelet aggregation when administered in vitro or in vivo

1974 • 102 citations

Essential Fatty Acid Diet Supplementation: Effects on Peripheral Nerve and Skeletal Muscle Function and Capillarization in Streptozocin-Induced Diabetic Rats

1991 • 101 citations

The influence of dietary manipulation with n−3 and n−6 fatty acids on liver and plasma phospholipid fatty acids in rats

1986 • 100 citations

The role of linoleic acid and its metabolites in the lowering of plasma cholesterol and the prevention of cardiovascular disease

1987 • 99 citations

Suppression of monosodium urate crystal—induced acute inflammation by diets enriched with gamma‐linolenic acid and eicosapentaenoic acid

1988 • 99 citations

Essential Fatty Acids in Serum Lecithin of Children with Atopic Dermatitis and in Umbilical Cord Serum of Infants with High or Low IgE Levels

1987 • 98 citations

Most biological effects of zinc deficiency corrected by γ-linolenic acid (18: 3ω6) but not by linoleic acid (18: 2ω6)

1982 • 95 citations

Possible role of prostaglandin E1 in the affective disorders and in alcoholism.

1980 • 94 citations

Effect of arachidonic acid in the alloxan-diabetic rat

1968 • 92 citations

Eicosanoid synthesis in 7,12‐dimethylbenz(a)anthracene‐induced mammary carcinomas in Sprague‐Dawley rats fed primrose oil, menhaden oil or corn oil diet

1988 • 92 citations

ESSENTIAL FATTY ACID DEFICIENCY

1981 • 92 citations

Evening primrose oil and treatment of premenstrual syndrome

1990 • 91 citations

Differential regulation of the formation of prostaglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. I. effects of ethanol

1979 • 91 citations

Membrane-Disruptive Effect of Human Milk: Inactivation of Enveloped Viruses

1986 • 87 citations

Recurrent viral infections in patients with past or present atopic dermatitis

1986 • 87 citations

Some effects of the essential fatty acids linoleic acid and alpha-linolenic acid and of their metabolites gamma-linolenic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and of prostaglandins A1 and E1 on the proliferation of human osteogenic sarcoma cells in culture

1984 • 87 citations

Oxidative metabolism of dihomogammalinolenic acid by guinea pig epidermis: Evidence of generation of anti-inflammatory products

1988 • 86 citations

The effects of dietary cholesterol on blood and liver polyunsaturated fatty acids and on plasma cholesterol in rats fed various types of fatty acid diet

1984 • 86 citations

Human tissue lipids: occurrence of fatty acid isomers from dietary hydrogenated oils.

1981 • 86 citations

Lipids in breast carcinogenesis

1989 • 84 citations

The reversibility of cancer: The relevance of cyclic AMP, calcium, essential fatty acids and prostaglandin E1

1980 • 83 citations

Intensification of Essential Fatty Acid Deficiency in the Rat by Dietary trans Fatty Acids

1979 • 83 citations

Prostaglandin and Lipid Metabolism in Radiation Injury

1987 • 82 citations

Tissue phospholipid fatty acid composition in the diabetic rat

1984 • 79 citations

Nutrition imbalance and angiotoxins as dietary risk factors in coronary heart disease

1979 • 79 citations

Breast milk fatty acids in mothers of children with atopic eczema

1989 • 78 citations

Gammalinolenic acid-enriched diet alters cutaneous eicosanoids

1988 • 77 citations

A pathologic study of benign breast diseases in Tokyo and New York

1982 • 75 citations

Suppression of acute and chronic inflammation by dietary gamma linolenic acid.

1989 • 75 citations

Alteration of the cellular fatty acid profile and the production of eicosanoids in human monocytes by gamma‐linolenic acid

1990 • 75 citations

Essential fatty acids in plasma, red blood cells and liver phospholipids in common laboratory animals as compared to humans

1984 • 74 citations

Is the origin of atopy linked to deficient conversion of ω-6-fatty acids to prostaglandin E1?

1989 • 74 citations

Membrane fatty acid modification in tumor cells: A potential therapeutic adjunct

1987 • 74 citations

Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles

1973 • 74 citations

Omega-6 Essential Fatty Acids

1991 • 73 citations

Essential fatty acids, diabetes, and cholesterol

1955 • 73 citations

Acylglycerol structure of peanut oils of different atherogenic potential

1977 • 72 citations

ECZEMA AND ESSENTIAL FATTY ACIDS

1947 • 71 citations

Interaction between prostaglandins and calcium: The importance of bell-shaped dose-response curves

1977 • 71 citations

Extreme Sensitivity of Enveloped Viruses, Including Herpes Simplex, to Long-Chain Unsaturated Monoglycerides and Alcohols

1979 • 71 citations

Effects of polyunsaturated fatty acids and of their oxidation products on cell survival

1987 • 70 citations

Failure of Fe2+-induced lipid peroxidation and swelling in the mitochondria isolated from ascites tumor cells

1965 • 70 citations

Anti-PGE antibodies inhibit in vivo development of cell-mediated immunity

1981 • 69 citations

Essential fatty acids in clinical dermatology

1989 • 69 citations

EXUDATIVE DIABETIC RETINOPATHY SPONTANEOUS CHANGES AND EFFECTS OF A CORN OIL DIET

1963 • 69 citations

Effect of magnesium deficiency on Δ6 desaturase activity and fatty acid composition of rat liver microsomes

1989 • 67 citations

Low dietary intake of linoleic acid predisposes to myocardial infarction

1982 • 67 citations

Some possible effects on lipid biochemistry of differences in the distribution on glycerol of long-chain n − 3 fatty acids in the fats of marine fish and marine mammals

1988 • 65 citations

SERUM LIPIDS IN ECZEMA AND IN OTHER PATHOLOGIC CONDITIONS

1937 • 64 citations

Dietary Fat in Relation to Prognostic Indicators in Breast Cancer

1988 • 64 citations

Suppression of human synovial cell proliferation by dihomo‐γ‐linolenic acid

1989 • 64 citations

Polyunsaturated fatty acids and diabetic retinopathy.

1985 • 64 citations

Essential fatty acid treatment ? effects on nerve conduction, polyol pathway and axonal transport in streptozotocin diabetic rats

1989 • 64 citations

Influence of Fats and Fatty Acids on the Capillaries

1953 • 63 citations

Ethanol and prostaglandin E1: Biochemical and behavioral interactions

1980 • 63 citations

γ-Linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome Δ6-desaturase activity

1991 • 62 citations

Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome

1984 • 62 citations

Essential Fatty Acids, Prostaglandins, and Alcoholism: An Overview

1987 • 61 citations

In vivo incorporation of labeled fatty acids in rat liver lipids after oral administration

1987 • 60 citations

The unsaturated and polyunsaturated fatty acids in health and disease.

1976 • 60 citations

Essential fatty acids prevent slowed nerve conduction in streptozotocin diabetic rats

1988 • 59 citations

Essential Fatty Acid Depletion of Renal Allografts and Prevention of Rejection

1988 • 59 citations

Treatment of Rheumatoid Arthritis with Prostaglandin E₁, Precursors CIS-Linoleic Acid and γ-Linolenic Acid

1983 • 58 citations

The pineal and regulation of fibrosis: Pinealectomy as a model of primary biliary cirrhosis: Roles of melatonin and prostaglandins in fibrosis and regulation of T lymphocytes

1979 • 58 citations

Favorable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy in adult onset diabetes mellitus

1981 • 58 citations

Comparative in vivo and in vitro Study of the Influence of Experimental Diabetes on Rat Liver Linoleic Acid Δ6- and Δ5-Desaturation

1985 • 58 citations

Interactions between n-3 and n-6 essential fatty acids (EFAs) in the regulation of cardiovascular disorders and inflammation

1991 • 58 citations

Mitochondrial and microsomal phospholipids of Morris hepatoma 7777.

1977 • 57 citations

Altered blood rheology in the pathogenesis of diabetic and other neuropathies

1988 • 57 citations

The nutritional and metabolic impact of γ-linolenic acid (18:3ω6) on cats deprived of animal lipid

1978 • 57 citations

Metabolism of fatty acids of the linoleic acid series in testicles of diabetic rats

1970 • 57 citations

A new concept of lifestyle-related cardiovascular disease: The importance of interactions between cholesterol, essential fatty acids, prostaglandin E1 and thromboxane A2

1980 • 56 citations

Altered microsomal phospholipid composition in the streptozotocin diabetic rat

1983 • 56 citations

Metabolism of Gamma-Linolenic Acid in Essential Fatty Acid-deficient Rats

1977 • 55 citations

Defective desaturation and elongation of N-6 and N-3 fatty acids in hypertensive patients

1984 • 54 citations

Dietary Fats and the Diabetic Patient

1959 • 54 citations

Purification and chemical characterisation of the inhibitor of lipid peroxidation from intestinal mucosa

1988 • 53 citations

Competitive inhibitions in the metabolism of polyunsaturated fatty acids studied via the composition of phospholipids, triglycerides and cholesteryl esters of rat tissues

1965 • 52 citations

Fatty Acid Effects on Angiotensin Receptors

1986 • 51 citations

Fatty acid composition of phospholipids in erythrocyte membranes and risk of breast cancer

1990 • 51 citations

Implications of Dietary Oils and Polyunsaturated Fatty Acids in the Management of Cutaneous Disorders

1989 • 50 citations

Improvement of diabetic control by continuous subcutaneous insulin infusion therapy changes fatty acid composition of serum lipids and erythrocytes in Type 1 (insulin-dependent) diabetes

1986 • 50 citations

Cellular basis of prolactin action: Involvement of cyclic nucleotides, polyamines, prostaglandins, steroids, thyroid hormones, ATPases and calcium: Relevance to breast cancer and the menstrual cycle

1979 • 50 citations

Cytotoxic effects of essential fatty acids (EFA) in mixed cultures of normal and malignant human cells

1986 • 49 citations

The reversibility of cancer: evidence that malignancy in melanoma cells is gamma-linolenic acid deficiency-dependent.

1982 • 49 citations

Levels of essential and other fatty acids in plasma and red cell phospholipids from normal controls and patients with atopic eczema.

1991 • 48 citations

Effects of dietary primrose oil on mammary tumorigenesis induced by 7,12‐dimethylbenz(a) anthracene

1987 • 47 citations

Metabolism in vivo of deuterium-labelled linolenic and linoleic acids in humans

1990 • 47 citations

Fatty acid and prostaglandin metabolism in children with diabetes mellitus. II. — The effect of evening primrose oil supplementation on serum fatty acid and plasma prostaglandin levels

1991 • 47 citations

Patients with Primary Sjögren's Syndrome Treated for Two Months with Evening Primrose Oil

1986 • 46 citations

Plasma fatty acid levels in patients with acquired immune deficiency syndrome and in controls

1989 • 46 citations

Epstein-Barr Virus Antibodies in Children with Atopic Disease

1981 • 46 citations

Nutrition and Immunity: The Immunoregulatory Effect of n-6 Essential Fatty Acids Is Mediated through Prostaglandin E

1985 • 45 citations

Potential diagnostic value of the umbilical artery as a definition of neural fatty acid status of the fetus during its growth: the umbilical artery as a diagnostic tool

1990 • 44 citations

Hypocholesterolemic Effect of Gamma-Linolenic Acid as Evening Primrose Oil in Rats

1986 • 44 citations

CIGARETTE SMOKING, POLYUNSATURATED FATS, LINOLEIC ACID, AND CORONARY HEART DISEASE

1989 • 44 citations

Accumulation of Linoleic and γ-Linolenic Acids in Tissue Lipids of Pyridoxine-Deficient Rats

1984 • 44 citations

Effects of Biotin Deficiency on Polyunsaturated Fatty Acid Metabolism in Rats

1984 • 43 citations

The effect of dietary n−6 and n−3 polyunsaturated fatty acids on blood pressure and tissue fatty acid composition in spontaneously hypertensive rats

1989 • 43 citations

Primary Sj�gren's syndrome treated with Efamol/Efavit

1984 • 42 citations

Increased Serum Levels of Antibodies to Epstein-Barr Virus in Adults with History of Atopic Dermatitis

1984 • 42 citations

Inactivation of Lipid‐Enveloped Viruses in Labile Blood Derivatives by Unsaturated Fatty Acids

1988 • 42 citations

Divergent effects of omega-6 and omega-3 fatty acids on mammary tumor development in C3H/Heston mice treated with DMBA

1989 • 41 citations

Evening Primrose Oil (Efamol) in the Treatment of Raynaud’s Phenomenon: A Double Blind Study

1985 • 41 citations

Changes in human plasma essential fatty acid levels as a result of administration of linoleic acid and gamma-linolenic acid.

1988 • 40 citations

The effect of an unsaturated-fat diet on cataract formation in streptozotocin-induced diabetic rats

1976 • 40 citations

Supplementation with evening primrose oil in atopic dermatitis: Effect on fatty acids in neutrophils and epidermis

1991 • 40 citations

The acyl-CoA desaturases of microsomes from rat liver and the Morris 7777 hepatoma

1979 • 39 citations

Interferon-Resistant Cell Line Lacks Fatty Acid Cyclooxygenase Activity

1981 • 38 citations

Some effects of gamma-linolenic acid on cultured human oesophageal carcinoma cells.

1982 • 38 citations

Evening primrose oil, a dietary prostaglandin precursor, diminishes vascular reactivity to renin and angiotensin ii in rats

1982 • 38 citations

Essential fatty acids in chronic alcoholism.

1979 • 38 citations

Evidence for a structurally specific role of essential polyunsaturated fatty acids depending on their peculiar double-bond distribution in biomembranes

1990 • 37 citations

Synthesis of estradiol fatty acid esters by human breast tumors: Fatty acid composition and comparison to estrogen and progesterone receptor content

1985 • 37 citations

Dihomo-δ-linolenic acid increases the metabolism of eicosapentaenoic acid in perfused vascular tissue

1985 • 35 citations

The action of insulin and dibutyryl cyclic AMP on the biosynthesis of polyunsaturated acids ofα-linolenic acid family in HTC cells

1976 • 35 citations

Selective turnover of the essential fatty acid ester components of estradiol-17β lipoidal derivatives formed by human mammary cancer cells in culture

1987 • 34 citations

Dihomo‐γ‐linolenic acid reverses hypertension induced in rats by diets rich in saturated fat

1984 • 34 citations

Actions of an Estradiol-17-Fatty Acid Ester in Estrogen Target Tissues of the Rat: Comparison with Other C-17 Metabolites and a Pharmacological C-17 Ester*

1989 • 32 citations

Atopic dermatitis and essential fatty acids: a biochemical basis for atopy?

1985 • 32 citations

Is the main problem in free radical damage caused by radiation, oxygen and other toxins the loss of membrane essential fatty acids rather than the accumulation of toxic materials?

1991 • 31 citations

Lack of feedback control of fatty acid synthesis in a transplantable hepatoma

1966 • 31 citations

Influences of Diet and Postnatal Age on the Lipid Composition of Red Blood Cell Membrane in Newborn Infants

1988 • 31 citations

Dietary N−6 and N−3 fatty acids and salt‐induced hypertension in the borderline hypertensive rat

1989 • 31 citations

George O. Burr and the Discovery of Essential Fatty Acids

1988 • 29 citations

The effect of prostaglandin precursors in in vivo models of cell-mediated immunity

1981 • 29 citations

Volume and hyperplastic lesions of breasts of Japanese women in Hawaii and Japan

1978 • 28 citations

N-6 polyunsaturated fatty acids in human breast carcinoma phosphatidylethanolamine and early relapse

1990 • 28 citations

The effects of evening primrose oil, safflower oil and paraffin on plasma fatty acid levels in humans: Choice of an appropriate placebo for clinical studies on primrose oil

1991 • 28 citations

Effects of C18 fatty acids on breast carcinoma cells in culture.

1987 • 28 citations

Use of gamma-linolenic acid in the treatment of schizophrenia and tardive dyskinesia

1992 • 26 citations

Selected fatty acids as possible intermediates for selective cytotoxic activity of anticancer agents involving oxygen radicals.

1986 • 26 citations

Pathogenesis of Diabetic Neuropathy: the Role of the n‐6 Essential Fatty Acids and their Eicosanoid Derivatives

1990 • 25 citations

Response of tissue phospholipid fatty acid composition to dietary (n-6) and replacement with marine (n-3) and saturated fatty acids in the rat

1986 • 25 citations

The Role of Essential Fatty Acids in Alcohol Dependence and Tissue Damage

1987 • 25 citations

Comparison of the fatty acid component in structural lipids from dolphins, zebra and giraffe: possible evolutionary implications

1987 • 25 citations

Aspirin augments alcohol in restricting brain growth in the neonatal rat

1989 • 24 citations

In vitro activity of Δ6 and Δ9 desaturases in hepatomas of different growth rates

1974 • 24 citations

Oral gamma‐Iinolenic acid in 21 patients with unbeatable malignancy. An ongoing pilot open clinical trial

1987 • 23 citations

Paradoxical effects of essential fatty acid supplementation on lipid profiles and sweat electrolytes in cystic fibrosis

1990 • 23 citations

The effect of gamma-linolenic acid on the growth of human osteogenic sarcoma and oesophageal carcinoma cells in culture.

1984 • 23 citations

Post-viral fatigue syndrome, viral infections in atopic eczema, and essential fatty acids

1990 • 23 citations

Differential resorption rates of subcutaneous implants of [3H]cholesterol, various [3H]cholesterol esters and [3H]cholesterol-[1-14C]linolenate

1969 • 22 citations

Viral infections in atopic dermatitis.

1985 • 21 citations

Essential fatty acids and atopic dermatitis

1991 • 21 citations

The influence of dietary marine oil (POLEPA) and evening primrose oil (Efamol) on prostaglandin production by the rat mesenteric vasculature

1987 • 20 citations

Serum fatty acid proportions are altered during the year following acute Epstein‐Barr virus infection

1988 • 20 citations

Inhibition of the binding of R-5020 and rat uterine progesterone receptors by long chain fatty acids.

1986 • 20 citations

Fatty Acid Composition of Serum Phospholipids in an Elderly Institutionalized Japanese Population.

1991 • 19 citations

The response of human carcinoma cell lines to gamma-linolenic acid with special reference to the effects of agents which influence prostaglandin and thromboxane synthesis

1985 • 19 citations

Effects of essential fatty acid administration on cardiovascular responses to stress in the rat

1986 • 19 citations

ESSENTIAL FATTY ACIDS AND THE SKIN

1958 • 18 citations

Species-dependent regulation of monocyte/macrophage Ia antigen expression and antigen presentation by prostaglandin E

1986 • 17 citations

ESSENTIAL FATTY ACIDS IN CORD BLOOD LYMPHOCYTES OF INFANTS “AT RISK” FOR ATOPY

1989 • 16 citations

Precursor- and pool-dependent differential effects of ethanol on human platelet prostanoid synthesis

1985 • 16 citations

The effect of dietary supplementation with linoleic and gammalinolenic acids on the pressor response to angiotensin II‐a possible role in pregnancy‐induced hypertension?

1985 • 15 citations

Indirect Evidence of Impairment of Platelet Desaturase Enzymes in Diabetes Mellitus

1986 • 15 citations

Effects of safflower oil and evening primrose oil in men with a low dihomo-γ-linolenic level

1990 • 15 citations

The human nutritional advantages of plant foods over animal foods

1979 • 15 citations

Significance of Linoleic Acid in the Metabolism and Therapy of Diabetes mellitus

2015 • 15 citations

Gamma linolenic acid attenuates cardiovascular responses to stress in borderline hypertensive rats

1985 • 14 citations

Effect of isoessential fatty acid lipids from animal and plant sources on cholesterol levels in mature male rats

1966 • 13 citations

Protection against ethanol-induced embryonic damage by administering gamma-linolenic and linoleic acids.

1982 • 13 citations

I. Role of Unsaturated Dietary Fat in Infant Nutrition

1957 • 12 citations

The influence of α-linolenic acid (18: 3ω3) on the metabolism of γ-linolenic acid (18: 3ω6) in the rat

1977 • 12 citations

The effect of combined fish oil and evening primrose oil (Efamol Marine) on the remission phase of psoriasis: A 7-month double-blind randomized placebo-controlled trial

1993 • 12 citations

Effects of postnatal age and diet on the fatty acid composition of plasma lipid fractions in preterm infants.

1989 • 11 citations

Effects of prostaglandins and their precursors in some tests of hemostatic function

1981 • 10 citations

Metabolism of n − 3/n − 6 fatty acids in blood and vascular cells

1990 • 9 citations

Effects of essential fatty acids on mild to moderate essential hypertension

1988 • 9 citations

The modulation of autoimmunity in the MRL-mp-lpr/lpr mouse by dietary fatty acid supplementation

1986 • 9 citations

Stearolic Acid, an Essential Fatty Acid?

1954 • 9 citations

Is the triene/tetraene ratio always a valid indicator of functional essential fatty acid deficiency?

1981 • 8 citations

Effects of N−3 and N−6 fatty acid supplementation on cardiovascular and endocrine responses to stress in the rat

1989 • 8 citations

REPEATED AUTOMATED ASSESSMENT OF ABSTINENT MALE ALCOHOLICS: ESSENTIAL FATTY ACID SUPPLEMENTATION AND AGE EFFECTS

1989 • 8 citations

Effect of dietary fatty acids on experimental manifestation of salmonella-associated arthritis in rats II. Effect of dietary fatty acids on experimental manifestation of salmonella-associated arthritis in rats

1987 • 8 citations

Premenstrual syndrome and atopy: a double-blind clinical evaluation of treatment with a gamma-globulin/histamine complex.

1980 • 7 citations

Effects of calcium deprivation on n-6 fatty acid metabolism in growing rats

1988 • 7 citations

Carbon monoxide poisoning.

1984 • 7 citations

Effects of Dietary Biotin and Linoleate on Polyunsaturated Fatty Acids in Tissue Phospholipids

1987 • 7 citations

Chronic toxicity studies of Efamol evening primrose oil in rats and dogs

1988 • 7 citations

Dihomo-γ-linolenic acid increases prostacyclin production and reduces platelet thromboxane synthesis in the rat

1986 • 6 citations

The effects of short term dietary supplementation with evening primose of safflower oil on fatty acid and prostaglandin release from perfused mesenteric vascular beds in spontaneously hypertensive rats

1988 • 6 citations

Dihomogammalinolenic acid inhibits platelet aggregation and stimulates platelet prostaglandin E1 production in healthy subjects but not in insulin dependent diabetics

1986 • 5 citations

Influence of Omega-3 Fatty Acids on the Prostaglandin-Metabolism in Healthy Volunteers and Patients Suffering from PVD

1992 • 5 citations

Limiting the range of polyenoic fatty acids available from purified diets affects the growth of domestic cats.

1989 • 4 citations

Partial reversal of plasma and red cell essential fatty acid abnormalities in chronic urticaria with evening primrose oil

1990 • 2 citations