Heme Oxygenase 1 Gene Transfer Prevents CD95/Fas Ligand-Mediated Apoptosis and Improves Liver Allograft Survival via Carbon Monoxide Signaling Pathway

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

1997 • 2,481 citations

Reduced stress defense in heme oxygenase 1-deficient cells

1997 • 1,263 citations

Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis

2000 • 970 citations

Heme oxygenase: A novel target for the modulation of inflammatory response

1996 • 784 citations

Expression of heme oxygenase-1 can determine cardiac xenograft survival

1998 • 621 citations

Haem oxygenase-1 prevents cell death by regulating cellular iron

1999 • 519 citations

Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury

1999 • 493 citations

Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury

1999 • 489 citations

Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes

1998 • 466 citations

Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase.

1987 • 466 citations

Carbon Monoxide Generated by Heme Oxygenase-1 Suppresses the Rejection of Mouse-to-Rat Cardiac Transplants

2001 • 455 citations

Cloning and expression of cDNA for rat heme oxygenase.

1985 • 451 citations

Accommodation of vascularized xenografts: Expression of “protective genes” by donor endothelial cells in a host Th2 cytokine environment

1997 • 428 citations

Hepatic ischemia/reperfusion injury—a fresh look

2003 • 407 citations

Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis

2001 • 396 citations

Differential ability of T_h1 and T_h2 T cells to express Fas ligand and to undergo activation-induced cell death

1994 • 329 citations

Induction of Haem Oxygenase as a Defence Against Oxidative Stress

1990 • 322 citations

Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells.

1994 • 309 citations

Purification and characterization of biliverdin reductase from rat liver.

1981 • 298 citations

Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts

2000 • 296 citations

Heme Oxygenase-1–Derived Carbon Monoxide Contributes to the Suppression of Acute Hypertensive Responses In Vivo

1998 • 275 citations

Heme Oxygenase: Clinical Applications and Functions

1992 • 264 citations

Heme Oxygenase-1 Induction in Islet Cells Results in Protection From Apoptosis and Improved In Vivo Function After Transplantation

2001 • 263 citations

Ex vivoexposure to carbon monoxide prevents hepatic ischemia/reperfusion injury through p38 MAP kinase pathway

2002 • 227 citations

Protective genes expressed in endothelial cells: a regulatory response to injury

1997 • 222 citations

Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins.

1984 • 220 citations

A20 Inhibits Cytokine-Induced Apoptosis and Nuclear Factor κB–Dependent Gene Activation in Islets

1999 • 213 citations

Heme oxygenase-1 system in organ transplantation1

2002 • 199 citations

Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide

2000 • 192 citations

A novel multispecific competitor fragment for quantitative PCR analysis of cytokine gene expression in rats

1994 • 180 citations

Heme Oxygenase-1 Overexpression Protects Rat Livers from Ischemia/Reperfusion Injury with Extended Cold Preservation

2001 • 178 citations

Expression of perforin and granzymes in vivo: potential diagnostic markers for activated cytotoxic cells

1991 • 166 citations

Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice

2003 • 163 citations

Metabolism of inhaled dihalomethanes in vivo: Differentiation of kinetic constants for two independent pathways

1986 • 163 citations

HEME OXYGENASE-1 OVEREXPRESSION PROTECTS RAT HEARTS FROM COLD ISCHEMIA/REPERFUSION INJURY VIA AN ANTIAPOPTOTIC PATHWAY1

2002 • 158 citations

Heme oxygenase‐1 in growth control and its clinical application to vascular disease

2003 • 155 citations

APOPTOSIS AS A MECHANISM OF CELL DEATH IN LIVER ALLOGRAFT REJECTION1,2

1995 • 124 citations

APOPTOSIS AS A MECHANISM OF CELL DEATH IN LIVER ALLOGRAFT REJECTION1,2

1995 • 118 citations

Induction of Heme Oxygenase-1 Can Act Protectively against Cardiac Ischemia/Reperfusion in Vivo

2000 • 118 citations

Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32)

1998 • 114 citations

Differential roles of two types of the TNF receptor in TNF-induced cytotoxicity, DNA fragmentation, and differentiation.

1994 • 106 citations

Unique effects of zinc protoporphyrin on HO-1 induction and apoptosis

2001 • 100 citations

APOPTOSIS IN THE HUMAN ALLOGRAFTED KIDNEY

1995 • 89 citations

Apoptosis in the human liver during allograft rejection and end‐stage liver disease

1995 • 87 citations

The role of T cell apoptosis in transplantation tolerance

2000 • 83 citations

APOPTOSIS IN THE HUMAN ALLOGRAFTED KIDNEY

1995 • 80 citations

GAS-GENERATING SYSTEMS IN ACUTE RENAL ALLOGRAFT REJECTION IN THE RAT

1996 • 73 citations

Heme oxygenase-1 fused to a TAT peptide transduces and protects pancreatic β-cells

2003 • 68 citations

Regulatory Cells Potentiate the Efficacy of IL-4 Gene Transfer by Up-Regulating Th2-Dependent Expression of Protective Molecules in the Infectious Tolerance Pathway in Transplant Recipients

2000 • 56 citations

Heme Oxygenase 1 Mediates the Immunomodulatory and Antiapoptotic Effects of Interleukin 13 Gene TherapyIn VivoandIn Vitro

2002 • 55 citations

ALLEVIATION OF GRAFT-VERSUS-HOST DISEASE AFTER CONDITIONING WITH COBALT-PROTOPORPHYRIN, AN INDUCER OF HEME OXYGENASE-1

2000 • 43 citations

RDP1258, a New Rationally Designed Immunosuppressive Peptide, Prolongs Allograft Survival in Rats: Analysis of Its Mechanism of Action

1999 • 42 citations

FAS LIGAND GENE TRANSFER PROLONGS RAT RENAL ALLOGRAFT SURVIVAL AND DOWN-REGULATES ANTI-APOPTOTIC BAG-1 IN PARALLEL WITH ENHANCED TH2-TYPE CYTOKINE EXPRESSION1

2000 • 35 citations

Inhibition of Nitric Oxide Synthase Isoforms by Porphyrins

1996 • 29 citations

Pretreatment of small bowel isograft donors with cobalt-protoporphyrin decreases preservation injury

1999 • 27 citations

APOPTOSIS IN THE SMALL INTESTINAL ALLOGRAFT OF THE RAT1

1997 • 27 citations

Carboxyhemaglobin Levels in Methylene Chloride-Exposed Employees

1996 • 21 citations

Heme Oxygenase-1 Overexpression Protects Rat Livers from Ischemia/Reperfusion Injury with Extended Cold Preservation

2001 • 16 citations