HEME OXYGENASE-1 OVEREXPRESSION PROTECTS RAT HEARTS FROM COLD ISCHEMIA/REPERFUSION INJURY VIA AN ANTIAPOPTOTIC PATHWAY1

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1992 • 9,540 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

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Bilirubin Is an Antioxidant of Possible Physiological Importance

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Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

1997 • 2,481 citations

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

2000 • 2,074 citations

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

1994 • 1,431 citations

Reduced stress defense in heme oxygenase 1-deficient cells

1997 • 1,263 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury.

1996 • 1,116 citations

Ferritin: a cytoprotective antioxidant strategem of endothelium.

1992 • 1,100 citations

Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis

2000 • 970 citations

Apoptosis in Ischemic and Reperfused Rat Myocardium

1996 • 801 citations

Heme oxygenase: A novel target for the modulation of inflammatory response

1996 • 784 citations

Expression of heme oxygenase-1 can determine cardiac xenograft survival

1998 • 621 citations

Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury

1999 • 493 citations

Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury

1999 • 489 citations

Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes

1998 • 466 citations

Carbon Monoxide Generated by Heme Oxygenase-1 Suppresses the Rejection of Mouse-to-Rat Cardiac Transplants

2001 • 455 citations

Inhibition of Extracellular Signal–Regulated Kinase Enhances Ischemia/Reoxygenation–Induced Apoptosis in Cultured Cardiac Myocytes and Exaggerates Reperfusion Injury in Isolated Perfused Heart

2000 • 419 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

Induction of Haem Oxygenase as a Defence Against Oxidative Stress

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Leukocytes and Ischemia-Induced Myocardial Injury

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Reperfusion induces myocardial apoptotic cell death

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Purification and characterization of biliverdin reductase from rat liver.

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Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury

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Swelling, reductive stress, and cell death during chemical hypoxia in hepatocytes

1989 • 236 citations

Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide

2000 • 192 citations

Heme Oxygenase-1 Overexpression Protects Rat Livers from Ischemia/Reperfusion Injury with Extended Cold Preservation

2001 • 178 citations

Induction of Heme Oxygenase-1 Can Act Protectively against Cardiac Ischemia/Reperfusion in Vivo

2000 • 118 citations

Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32)

1998 • 114 citations

Free radicals and myocardial reperfusion injury

1993 • 71 citations

Effect of Heme Oxygenase Inhibitors on Soluble Guanylyl Cyclase Activity

1998 • 55 citations

RDP1258, a New Rationally Designed Immunosuppressive Peptide, Prolongs Allograft Survival in Rats: Analysis of Its Mechanism of Action

1999 • 42 citations

PRIOR INDUCTION OF HEAT SHOCK PROTEINS BY A NITRIC OXIDE DONOR ATTENUATES CARDIAC ISCHEMIA/REPERFUSION INJURY IN THE RAT1

2000 • 37 citations

Inhibition of Nitric Oxide Synthase Isoforms by Porphyrins

1996 • 29 citations

Pretreatment of small bowel isograft donors with cobalt-protoporphyrin decreases preservation injury

1999 • 27 citations