Phosphorylation of Retinoblastoma Protein Assayed in Individual HL-60 Cells during Their Proliferation and Differentiation

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Retinoblastoma protein recruits histone deacetylase to repress transcription

1998 • 1,231 citations

The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression

1987 • 1,180 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

1998 • 919 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

1994 • 625 citations

Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family

1998 • 545 citations

Thymidine Metabolism and Cell Kinetics

1968 • 542 citations

Thymidine metabolism and cell kinetics

1967 • 504 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

1997 • 435 citations

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T

1990 • 402 citations

The retinoblastoma protein pathway and the restriction point

1996 • 392 citations

Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle.

1996 • 305 citations

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

1991 • 304 citations

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

1993 • 271 citations

A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.

1996 • 251 citations

Subcompartments of the G1 phase of cell cycle detected by flow cytometry.

1980 • 207 citations

Multiple members of the E2F transcription factor family are the products of oncogenes.

1995 • 197 citations

Degradation of Retinoblastoma Protein in Tumor Necrosis Factor- and CD95-induced Cell Death

1997 • 170 citations

Correlated Measurements of DNA, RNA, and Protein in Individual Cells by Flow Cytometry

1985 • 153 citations

Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G₁

1996 • 139 citations

The role of E2F in the mammalian cell cycle

1993 • 136 citations

Growth imbalance and altered expression of cyclins B1, A, E, and D3 in MOLT-4 cells synchronized in the cell cycle by inhibitors of DNA replication.

1995 • 125 citations

The cell cycle: A practical approach

1994 • 114 citations

Rb functions to inhibit apoptosis during myocyte differentiation.

1997 • 110 citations

Tumor suppressor activity of RB and p53 genes in human breast carcinoma cells.

1993 • 97 citations

The Cell cycle : a practical approach

1993 • 94 citations

Expression and activity of the retinoblastoma protein (pRB)-family proteins, p107 and p130, during L6 myoblast differentiation.

1995 • 79 citations

Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells.

1993 • 76 citations

Differential regulation of the tumor suppressor molecules, retinoblastoma susceptibility gene product (Rb) and p53, during cell cycle progression of normal human T cells.

1991 • 71 citations

Cyclin-dependent kinase 6 is the principal target of p27/Kip1 regulation of the G1-phase traverse in 1,25-dihydroxyvitamin D3-treated HL60 cells.

1997 • 64 citations

Mutations of N-Terminal Regions Render the Retinoblastoma Protein Insufficient for Functions in Development and Tumor Suppression

1997 • 62 citations

Functional capabilities of molecular network components controlling the mammalian G1/S cell cycle phase transition

1998 • 61 citations

Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs

1997 • 60 citations

A System for Monocytic Differentiation of Leukemic Cells HL 60 by a Short Exposure to 1,25-Dihydroxycholecalciferol

1985 • 57 citations

Modulation of retinoblastoma gene in normal adult hematopoiesis: peak expression and functional role in advanced erythroid differentiation.

1995 • 55 citations

Role for E2F in DNA damage-induced entry of cells into S phase.

1997 • 54 citations

A dual block to cell cycle progression in HL60 cells exposed to analogues of vitamin D,

1994 • 52 citations

Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation.

1995 • 48 citations

Differentiation of P19 EC cells leads to differential modulation of cyclin-dependent kinase activities and to changes in the cell cycle profile.

1995 • 46 citations

Induced differentiation, the cell cycle, and the treatment of cancer

1996 • 45 citations

Phosphorylation of Retinoblastoma Susceptibility Gene Protein Assayed in Individual Lymphocytes during Their Mitogenic Stimulation

1998 • 42 citations

Uncoupling of Cell Cycle Arrest from the Expression of Monocytic Differentiation Markers in HL60 Cell Variants

1997 • 41 citations

Accumulation of E2F-4·DP-1 DNA Binding Complexes Correlates with Induction of dhfr Gene Expression during the G1 to S Phase Transition

1997 • 39 citations

Altered Expression of the Retinoblastoma Tumor-Suppressor Gene in Leukemic Cell Lines Inhibits Induction of Differentiation But Not G1-Accumulation

1997 • 36 citations

The retinoblastoma protein is partially phosphorylated during early G1 in cycling cells but not in G1 cells arrested with alpha-interferon.

1992 • 30 citations

E2F transcription factor action, regulation and possible role in human cancer

1997 • 28 citations

Changes in Proto-oncogene Expression Associated With Reversal of Macrophage-Like Differentiation of HL 60 Cells<xref ref-type="fn" rid="FN2">2</xref>

1987 • 27 citations

Study of the role of retinoblastoma protein in terminal differentiation of murine erythroleukemia cells.

1995 • 22 citations

E2F transcription factor action, regulation and possible role in human cancer

1997 • 21 citations

Changes in E2F DNA-binding activity during induced erythroid differentiation.

1996 • 21 citations

RB1 oncosuppressor gene over-expression inhibits tumor progression and induces melanogenesis in metastatic melanoma cells.

1996 • 19 citations

Increasing c-FMS (CSF-1 receptor) expression decreases retinoic acid concentration needed to cause cell differentiation and retinoblastoma protein hypophosphorylation.

1997 • 18 citations

Retinoblastoma protein-overexpressing HL60 cells resistant to 1,25-dihydroxyvitamin D3 display increased CDK2 and CDK6 activity and shortened G1 phase

1998 • 17 citations

Uncoupling of the order of the S and M phases: effects of staurosporine on human cell cycle kinases

1997 • 11 citations

Retinoic acid-induced RB (retinoblastoma) hypophosphorylation enhanced by CGP 52411 (4,5-dianilinophthalimide), an EGF family tyrosine kinase receptor inhibitor.

1996 • 11 citations

Uncoupling of the order of the S and M phases: effects of staurosporine on human cell cycle kinases

1997 • 4 citations