Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice.

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

"Panning" for lymphocytes: a method for cell selection.

1978 • 1,319 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes

1984 • 537 citations

Surface Antigen Expression and Immunoglobulin Gene Rearrangement During Mouse pre‐B Cell Development

1983 • 490 citations

Developmentally Controlled Expression of Immunoglobulin V _H Genes

1985 • 349 citations

Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma

1986 • 332 citations

Allelic Exclusion in Transgenic Mice That Express the Membrane form of Immunoglobulin μ

1987 • 293 citations

Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription.

1991 • 289 citations

Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line

1985 • 244 citations

A transgenic model of autoimmune hemolytic anemia.

1992 • 232 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

VHDJH formation and DJH replacement during pre-B differentiation: non-random usage of gene segments.

1986 • 186 citations

Developmentally regulated and strain-specific expression of murine VH gene families.

1988 • 186 citations

A transgenic immunoglobulin Mu gene prevents rearrangement of endogenous genes

1985 • 169 citations

MECHANISM AND DEVELOPMENTAL PROGRAM OF IMMUNOGLOBULIN GENE REARRANGEMENT IN MAMMALS

1989 • 144 citations

Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.

1988 • 138 citations

Transgenic Mice with Immunoglobulin Genes

1987 • 137 citations

VH gene family utilization in colonies derived from B and pre-B cells detected by the RNA colony blot assay.

1986 • 127 citations

V_H‐gene expression in murine lipopolysaccharide blasts distributes over the nine known V_H‐gene groups and may be random

1985 • 122 citations

The organization of the mouse Igh-V locus. Dispersion, interspersion, and the evolution of VH gene family clusters.

1988 • 116 citations

Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes

1990 • 91 citations

A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice

1988 • 75 citations

Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene.

1991 • 73 citations

Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice.

1987 • 72 citations

Organization of the murine immunoglobulin VH complex in the inbred strains.

1987 • 59 citations

Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse.

1989 • 55 citations

Rearrangement and expression of endogenous immunoglobulin genes occur in many murine B cells expressing transgenic membrane IgM.

1988 • 55 citations

Immunoglobulin V_H region genes of the mouse are organized in overlapping clusters

1987 • 51 citations

Stable propagation of the active transcriptional state of an immunoglobulin μ gene requires continuous enhancer function

1988 • 48 citations

Allelic exclusion in transgenic mice carrying mutant human IgM genes.

1988 • 42 citations

Endogenous V_H gene family expression in immunoglobulin-transgenic mice: evidence for selection of antibody repertoires

1991 • 31 citations

Endogenous immunoglobulin expression in mu transgenic mice

1991 • 25 citations

Quantitative analysis of idiotypic mimicry and allelic exclusion in mice with a mu Ig transgene.

1989 • 18 citations