p53-Regulated Apoptosis Is Differentiation Dependent in Ultraviolet B-Irradiated Mouse Keratinocytes

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Histopathology of the skin

1975 • 2,630 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.

1994 • 664 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis.

1994 • 377 citations

Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

1995 • 365 citations

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.

1995 • 351 citations

The human sunburn reaction: Histologic and biochemical studies

1981 • 283 citations

Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients.

1993 • 278 citations

Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo

1995 • 240 citations

Human epidermal cancer and accompanying precursors have identical p53 mutations different from p53 mutations in adjacent areas of clonally expanded non-neoplastic keratinocytes.

1996 • 156 citations

Evidence that a slowly cycling subpopulation of adult murine epidermal cells retains carcinogen.

1986 • 131 citations

Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines

1993 • 127 citations

Alternatively Spliced Forms in the Carboxy-Terminal Domain of the p53 Protein Regulate Its Ability to Promote Annealing of Complementary Single Strands of Nucleic Acids

1995 • 107 citations

Decreased DNA repair but normal apoptosis in ultraviolet-irradiated skin of p53-transgenic mice.

1996 • 105 citations

The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity.

1995 • 101 citations

p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein.

1995 • 95 citations

Two Pathways for Induction of Apoptosis by Ultraviolet Radiation in Cultured Human Keratinocytes

1997 • 92 citations

Evidence that cutaneous carcinogen-initiated epithelial cells from mice are quiescent rather than actively cycling.

1997 • 84 citations

Isolation of a full-length mouse cDNA clone coding for an immunologically distinct p53 molecule.

1985 • 78 citations

Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells.

1994 • 71 citations

Differentiation-dependent p53 regulation of nucleotide excision repair in keratinocytes.

1997 • 67 citations

Differential regulation of c-fos, fosB, c-jun, junB, bcl-2 and bax expression in rat skin following single or chronic ultraviolet irradiation and in vivo modulation by antisense oligodeoxynucleotide superfusion.

1994 • 63 citations

Mutant p53 expression in solar keratosis: an immunohistochemical study

1992 • 56 citations

Ultraviolet radiation induction of squamous cell carcinomas in p53 transgenic mice.

1995 • 52 citations

Isolation of a Full-Length Mouse cDNA Clone Coding for an Immunologically Distinct p53 Molecule

1985 • 38 citations

Site-specific comparison of p53 immunostaining in squamous cell carcinomas

1995 • 28 citations

Activities and response to DNA damage of latent and active sequence-specific DNA binding forms of mouse p53

1997 • 24 citations

Endogenous p53 Protein Generated from Wild-Type Alternatively Spliced p53 RNA in Mouse Epidermal Cells

1994 • 19 citations

Differential expression of the regularly spliced wild-type p53 and its COOH-terminal alternatively spliced form during epidermal differentiation.

1997 • 14 citations