Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance–linked ABCG2 transporter

Multidrug resistance in cancer: role of ATP–dependent transporters

2002 • 5,195 citations

Targeting multidrug resistance in cancer

2006 • 3,410 citations

Mammalian ABC Transporters in Health and Disease

2002 • 1,531 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.

1999 • 810 citations

Transmembrane Transport of Endo- and Xenobiotics by Mammalian ATP-Binding Cassette Multidrug Resistance Proteins

2006 • 740 citations

The Wide Pharmacological Versatility of Semicarbazones, Thiosemicarbazones and Their Metal Complexes

2004 • 723 citations

A Combined Assay of Cell Viability and in Vitro Cytotoxicity with a Highly Water-Soluble Tetrazolium Salt, Neutral Red and Crystal Violet.

1996 • 719 citations

Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System

2006 • 702 citations

Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan

2000 • 640 citations

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

1994 • 635 citations

P-glycoprotein and multidrug resistance

1996 • 549 citations

Predicting drug sensitivity and resistance

2004 • 517 citations

A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics

2006 • 486 citations

Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line.

1999 • 475 citations

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

2000 • 473 citations

Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.

2001 • 427 citations

The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells.

2002 • 398 citations

ABCG2: determining its relevance in clinical drug resistance

2007 • 373 citations

Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity

2003 • 347 citations

Overview: ABC transporters and human disease.

2001 • 342 citations

Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.

2001 • 338 citations

Pheophorbide a Is a Specific Probe for ABCG2 Function and Inhibition

2004 • 332 citations

Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport.

2003 • 303 citations

A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2)

2001 • 240 citations

Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein.

1990 • 223 citations

The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins

2005 • 208 citations

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance.

2000 • 196 citations

[37] Drug-stimulatable ATPase activity in crude membranes of human MDR1-transfected mammalian cells

1998 • 194 citations

Relation Between the Turnover Number for Vinblastine Transport and for Vinblastine-stimulated ATP Hydrolysis by Human P-glycoprotein

1997 • 190 citations

Selective Toxicity of NSC73306 in MDR1-Positive Cells as a New Strategy to Circumvent Multidrug Resistance in Cancer

2006 • 177 citations

Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines.

2000 • 176 citations

Thiopurine Metabolism and Identification of the Thiopurine Metabolites Transported by MRP4 and MRP5 Overexpressed in Human Embryonic Kidney Cells

2002 • 174 citations

Modulatory effects of plant phenols on human multidrug‐resistance proteins 1, 4 and 5 (ABCC1, 4 and 5)

2005 • 157 citations

A 190-Kilodalton Protein Overexpressed in Non-P-Glycoprotein-Containing Multidrug-Resistant Cells and Its Relationship to the MRP Gene

1994 • 143 citations

Modulation of the function of the multidrug resistance–linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin

2006 • 121 citations

Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter

2006 • 107 citations

The Calcium Channel Blockers, 1,4-Dihydropyridines, Are Substrates of the Multidrug Resistance-Linked ABC Drug Transporter, ABCG2

2006 • 99 citations

Importance of the Conserved Walker B Glutamate Residues, 556 and 1201, for the Completion of the Catalytic Cycle of ATP Hydrolysis by Human P-glycoprotein (ABCB1)

2002 • 94 citations

ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins

2004 • 89 citations

Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition

2004 • 81 citations

Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants

2003 • 81 citations

Oligomerization Domain of the Multidrug Resistance–Associated Transporter ABCG2 and Its Dominant Inhibitory Activity

2007 • 69 citations

Transport of SN-38 by the wild type of human ABC transporter ABCG2 and its inhibition by quercetin, a natural flavonoid.

2004 • 67 citations

Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2

2005 • 61 citations

Evidence for the Role of Glycosylation in Accessibility of the Extracellular Domains of Human MRP1 (ABCC1)

2002 • 54 citations

Multidrug Resistance Protein 4 (ABCC4)-mediated ATP Hydrolysis

2004 • 51 citations

Recent evaluations of thiosemicarbazones and semicarbazones and related compounds for antineoplastic and anticonvulsant activities.

1993 • 45 citations

Topoisomerase I Inhibitors in the Treatment of Gastrointestinal Cancer: From Intravenous to Oral Administration

2004 • 16 citations