Discrimination between RelA and RelB Transcriptional Regulation by a Dominant Negative Mutant of IκBα

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1991 • 746 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

1992 • 731 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

Transcriptional Regulation of the Intercellular Adhesion Molecule-1 Gene by Inflammatory Cytokines in Human Endothelial Cells

1995 • 540 citations

Improved resolution of myofibrillar proteins with sodium dodecyl sulfate-polyacrylamide gel electrophoresis

1977 • 532 citations

The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers

1993 • 506 citations

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

1995 • 477 citations

Inducible Nuclear Expression of Newly Synthesized IκBα Negatively Regulates DNA-Binding and Transcriptional Activities of NF-κB

1995 • 442 citations

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

1988 • 427 citations

The precursor of NF-κB p50 has IκB-like functions

1992 • 409 citations

Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis

1995 • 392 citations

Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B.

1992 • 373 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus.

1993 • 330 citations

NF-κB Subunit Regulation in Nontransformed CD4 ⁺ T Lymphocytes

1992 • 322 citations

Interactions of cellular proteins involved in the transcriptional regulation of the human immunodeficiency virus.

1987 • 306 citations

The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation.

1992 • 258 citations

Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation.

1992 • 245 citations

Three NF-χB sites in the IχB-α promoter are required for induction of gene expression by TNFα

1994 • 219 citations

Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivo.

1996 • 197 citations

Contribution of NF-kappa B and Sp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1: distinct patterns of viral growth are determined by T-cell types

1991 • 191 citations

Interaction of the COOH-terminal Transactivation Domain of p65 NF-κB with TATA-binding Protein, Transcription Factor IIB, and Coactivators

1995 • 157 citations

Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells

1993 • 149 citations

The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element.

1992 • 134 citations

Domain Organization of IκBα and Sites of Interaction with NF-κB p65

1995 • 124 citations

IκBα Overexpression in Human Breast Carcinoma MCF7 Cells Inhibits Nuclear Factor-κB Activation but Not Tumor Necrosis Factor-α-induced Apoptosis

1997 • 121 citations

Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity.

1994 • 114 citations

NK-kappa B subunit-specific regulation of the I kappa B alpha promoter.

1994 • 110 citations

Regulation of cytokine gene expression in T helper cell subsets.

1994 • 102 citations

Differential Transcriptional Activation in Vitro by NF- κB/Rel Proteins

1995 • 101 citations

Both N- and C-Terminal Domains of RelB Are Required for Full Transactivation: Role of the N-Terminal Leucine Zipper-Like Motif

1993 • 87 citations

The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus.

1993 • 85 citations

Dominant negative mutant of c-Jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription.

1994 • 81 citations

c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1.

1996 • 81 citations

NF-κB activation by tumor necrosis factor α in the jurkat T cell line is independent of protein kinase A, protein kinase C, and Ca2+-regulated kinases

1991 • 72 citations

Function of NF-κB/Rel Binding Sites in the Major Histocompatibility Complex Class II Invariant Chain Promoter Is Dependent on Cell-Specific Binding of Different NF-κB/Rel Subunits

1994 • 62 citations

NF-κB Sites Function as Positive Regulators of Expression of the Translocated c-myc Allele in Burkitt's Lymphoma

1994 • 54 citations

Inactivation of NF-κB Inhibitor IκBα: Ubiquitin-Dependent Proteolysis and Its Degradation Product

1995 • 53 citations

Promoter trans-activation of protooncogenes c-fos and c-myc, but not c-Ha-ras, by products of adenovirus early region 1A.

1987 • 52 citations

Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ

1996 • 51 citations

I kappa B alpha can localize in the nucleus but shows no direct transactivation potential.

1993 • 41 citations

Induction of Interleukin-2 Receptor-α Gene Expression Is Regulated by Post-translational Activation of κ B Specific DNA Binding Proteins

1989 • 32 citations

Nuclear Rel-A and c-Rel protein complexes are differentially distributed within human thymocytes.

1997 • 15 citations