Contribution of NF-kappa B and Sp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1: distinct patterns of viral growth are determined by T-cell types

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS

1984 • 3,566 citations

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1986 • 2,918 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)

1985 • 872 citations

Genome organization and transactivation of the human immunodeficiency virus type 2

1987 • 842 citations

The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat

1985 • 825 citations

In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity

1988 • 754 citations

Activation of the AIDS Retrovirus Promoter by the Cellular Transcription Factor, Sp1

1986 • 741 citations

Tat trans-activates the human immunodeficiency virus through a nascent RNA target

1989 • 644 citations

Commentary: “The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level”

2015 • 572 citations

Location of the Trans -Activating Region on the Genome of Human T-Cell Lymphotropic Virus Type III

1985 • 558 citations

HIV-1 tat trans-activation requires the loop sequence within tar

1988 • 551 citations

Trans -Acting Transcriptional Regulation of Human T-Cell Leukemia Virus Type III Long Terminal Repeat

1985 • 500 citations

Activation of the HIV-1 LTR by T Cell Mitogens and the Trans-Activator Protein of HTLV-I

1987 • 460 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

Nef Protein of HIV-1 Is a Transcriptional Repressor of HIV-1 LTR

1988 • 366 citations

Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat.

1989 • 357 citations

Characterization of a continuous T-cell line susceptible to the cytopathic effects of the acquired immunodeficiency syndrome (AIDS)-associated retrovirus.

1985 • 337 citations

Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappa B) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro.

1988 • 309 citations

Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation

1988 • 292 citations

The SV40 enhancer contains two distinct levels of organization

1988 • 286 citations

Human immunodeficiency virus type 1 LTR TATA and TAR region sequences required for transcriptional regulation.

1989 • 275 citations

A discrete element 3' of human immunodeficiency virus 1 (HIV-1) and HIV-2 mRNA initiation sites mediates transcriptional activation by an HIV trans activator.

1988 • 270 citations

Cooperativity and hierarchical levels of functional organization in the SV40 enhancer

1988 • 238 citations

trans activation of human immunodeficiency virus type 1 is sequence specific for both the single-stranded bulge and loop of the trans-acting-responsive hairpin: a quantitative analysis

1989 • 224 citations

Type C Virus-Producing Cell Lines Derived from Adult T Cell Leukemia

1982 • 215 citations

The NF-kappa B binding sites in the human immunodeficiency virus type 1 long terminal repeat are not required for virus infectivity

1989 • 215 citations

Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer

1990 • 193 citations

Role of SP1-binding domains in in vivo transcriptional regulation of the human immunodeficiency virus type 1 long terminal repeat

1989 • 188 citations

Constitutive and inducible Saccharomyces cerevisiae promoters: evidence for two distinct molecular mechanisms.

1986 • 181 citations

Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer elements.

1988 • 174 citations

Characterization of Antigen Receptor Response Elements within the Interleukin-2 Enhancer

1988 • 143 citations

Nuclear factor 1 interacts with five DNA elements in the promoter region of the human cytomegalovirus major immediate early gene.

1986 • 137 citations

Binding of transcription factors and creation of a large nucleoprotein complex on the human cytomegalovirus enhancer.

1987 • 123 citations

TAR independent activation of the human immunodeficiency virus in phorbol ester stimulated T lymphocytes.

1990 • 121 citations

Cooperative interactions between transcription factors Sp1 and OTF-1.

1990 • 114 citations

Effects of long terminal repeat mutations on human immunodeficiency virus type 1 replication

1989 • 105 citations

Applications of the Polymerase Chain Reaction in Retroviral-Mediated Gene Transfer and the Analysis of Gene-Marked Human TIL Cells

1990 • 98 citations

Variable role of the long terminal repeat Sp1-binding sites in human immunodeficiency virus replication in T lymphocytes

1991 • 90 citations

Constitutive and Inducible Saccharomyces cerevisiae Promoters: Evidence for Two Distinct Molecular Mechanisms

1986 • 52 citations

xB elements strongly activate gene expression in non-lymphoid cells and function synergistically with NF1 elements

1989 • 8 citations