The role of recombinational hotspots in genome instability in mammalian cells

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

1989 • 3,180 citations

Double-strand breaks at an initiation site for meiotic gene conversion

1989 • 533 citations

Genetic and physical linkage of exogenous sequences in transformed cells

1980 • 486 citations

Recent progress in understanding mechanisms of mammalian DNA amplification

1989 • 469 citations

Escherichia coli K-12 restricts DNA containing 5-methylcytosine.

1986 • 325 citations

An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae

1989 • 305 citations

Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia

1987 • 293 citations

HOMOLOGOUS RECOMBINATION IN MAMMALIAN CELLS

1989 • 262 citations

The importance of circular DNA in mammalian gene amplification.

1989 • 234 citations

Hypervariable minisatellite DNA is a hotspot for homologous recombination in human cells

1990 • 226 citations

Association of Crossover Points with Topoisomerase I Cleavage Sites: A Model for Nonhomologous Recombination

1985 • 218 citations

DNA amplification is rare in normal human cells.

1990 • 192 citations

Normal diploid human and rodent cells lack a detectable frequency of gene amplification.

1990 • 179 citations

A sex chromosome rearrangement in a human XX male caused by Alu—Alu recombination

1987 • 154 citations

Molecular Analysis of the Hotspot of Recombination in the Murine Major Histocompatibility Complex

1986 • 154 citations

The Z-DNA motif d(TG)30 promotes reception of information during gene conversion events while stimulating homologous recombination in human cells in culture.

1990 • 147 citations

Large inverted duplications are associated with gene amplification

1986 • 147 citations

Characterization of an Episome Produced in Hamster Cells that Amplify a Transfected CAD Gene at High Frequency: Functional Evidence for a Mammalian Replication Origin

1987 • 137 citations

Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules.

1988 • 137 citations

Early dihydrofolate reductase gene amplification events in CHO cells usually occur on the same chromosome arm as the original locus.

1989 • 132 citations

Homologous recombination in E. coli: Multiple pathways for multiple reasons

1989 • 119 citations

Genomic rearrangements in a mouse cell line containing integrated SV40 DNA

1981 • 108 citations

Loss of polymorphic restriction fragments in malignant melanoma: implications for tumor heterogeneity.

1985 • 106 citations

Regional chromosome localization of human papillomavirus intergration sites near fragile sites, oncogenes, and cancer chromosome breakpoints

1988 • 98 citations

Chromosomal destabilization during gene amplification.

1990 • 94 citations

Gene amplification: an example of accelerated evolution in tumorigenic cells.

1985 • 94 citations

Novel submicroscopic extrachromosomal elements containing amplified genes in human cells

1987 • 85 citations

Molecular mechanisms of oncogenesis.

1989 • 84 citations

Hamster cells with increased rates of DNA amplification, a new phenotype

1987 • 83 citations

Recombination events during integration of transfected DNA into normal human cells

1990 • 77 citations

Molecular characterization of a meiotic recombinational hotspot enhancing homologous equal crossing-over.

1986 • 70 citations

Cloning and characterization of the integrated viral DNA from three lines of SV40-transformed mouse cells

1981 • 66 citations

Integration of human papillomavirus 16 DNA and genomic rearrangements in immortalized human keratinocyte lines.

1990 • 65 citations

Extremely large chromosomal deletions are intimately involved in genetic instability and genomic rearrangements inStreptomyces glaucescens

1989 • 53 citations

Moderate-Level Gene Amplification in Methotrexate-Resistant Chinese Hamster Ovary Cells is Accompanied by Chromosomal Translocations At or Near the Site of the Amplified DHFR Gene

1984 • 51 citations

High frequency DNA rearrangements associated with mouse centromeric satellite DNA

1986 • 46 citations

Inducible gene expression by DNA rearrangements in human cells.

1986 • 43 citations

Rearrangement of integrated viral DNA sequences in mouse cells transformed by simian virus 40

1981 • 39 citations

Chromosome instability associated with human alphoid DNA transfected into the Chinese hamster genome.

1988 • 38 citations

Integration sites and sequence arrangement of SV40 DNA in a homogeneous series of transformed rat fibroblast lines

1980 • 37 citations

A DNA sequence conferring high postmeiotic segregation frequency to heterozygous deletions in Saccharomyces cerevisiae is related to sequences associated with eucaryotic recombination hotspots.

1988 • 33 citations

[14] Host strains that alleviate underrepresentation of specific sequences: Overview

1987 • 33 citations

Requirements for Excision and Amplification of Integrated Viral DNA Molecules in Polyoma Virus-Transformed Cells

1982 • 33 citations

Factors which equalize the representation of genome segments in recombinant libraries

1986 • 32 citations

Moderate-level gene amplification in methotrexate-resistant Chinese hamster ovary cells is accompanied by chromosomal translocations at or near the site of the amplified DHFR gene.

1984 • 31 citations

Rearrangements of host and viral DNA in mouse cells transformed by Simian virus 40

1984 • 31 citations

Instability of integrated viral DNA in mouse cells transformed by simian virus 40.

1981 • 31 citations

Preferential amplification of rearranged sequences near amplified adenylate deaminase genes.

1988 • 31 citations

The role of acentric chromosome fragments in gene amplification

1987 • 30 citations

High frequency of large spontaneous deletions of DNA in tumor-derived CHEF cells.

1989 • 28 citations

Unstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification.

1987 • 26 citations

Integration, loss, and reacquisition of defective viral DNA in SV40-transformed mouse cell lines

1983 • 22 citations

The mutagenic and carcinogenic effects of gene transfer

1989 • 22 citations

Association of high rate of recombination with amplification of dominant selectable gene in human cells

1988 • 22 citations

Unstable expression and amplification of a transfected oncogene in confluent and subconfluent cells.

1985 • 20 citations

Spontaneous rearrangement of integrated simian virus 40 DNA in nine transformed rodent cell lines

1989 • 19 citations

Nucleotide sequence of an unequal sister chromatid exchange site in a mouse myeloma cell line.

1989 • 18 citations

Events preceding stable integration of SV40 genomes in a human cell line

1983 • 16 citations

Nucleotide sequence analysis of novel junctions near an unstable integrated plasmid in human cells

1989 • 15 citations

DNA Sequence Responsible for the Amplification of Adjacent Genes

1987 • 13 citations

Influence of cellular sequences on instability of plasmid integration sites in human cells

1990 • 11 citations

Preferential loss or inactivation of chromosome Z4APRT allele in CHO cells

1989 • 7 citations

Molecular Mechanisms of Oncogenesis

1990 • 6 citations

Unstable Expression and Amplification of a Transfected Oncogene in Confluent and Subconfluent Cells

1985 • 6 citations