The Generation of Neuronal Diversity in the Drosophila Embryonic Central Nervous System

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

1985 • 1,063 citations

Expression of engrailed proteins in arthropods, annelids, and chordates

1989 • 1,019 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

1987 • 756 citations

Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogaster

1988 • 720 citations

Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors

1990 • 533 citations

The midline of the drosophila central nervous system: A model for the genetic analysis of cell fate, cell migration, and growth cone guidance

1991 • 497 citations

Characterization and localization of the even-skipped protein of Drosophila.

1987 • 496 citations

Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans

1981 • 494 citations

On the phenotype and development of mutants of early neurogenesis inDrosophila melanogaster

1983 • 493 citations

From grasshopper to Drosophila: a common plan for neuronal development

1984 • 475 citations

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

1989 • 472 citations

Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communication

1989 • 452 citations

The prospero gene specifies cell fates in the drosophila central nervous system

1991 • 442 citations

Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells.

1991 • 441 citations

The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates

1990 • 430 citations

Subtle Cerebellar Phenotype in Mice Homozygous for a Targeted Deletion of the En-2 Homeobox

1991 • 416 citations

Regulation and function of the Drosophila segmentation gene fushi tarazu

1987 • 415 citations

Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein

1985 • 406 citations

Early events in insect neurogenesis

1985 • 403 citations

rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.

1990 • 389 citations

Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo

1988 • 381 citations

Early neurogenesis in wild-typeDrosophila melanogaster

1984 • 372 citations

Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes

1987 • 370 citations

The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product

1988 • 353 citations

Expression and Function of the Segmentation Gene fushi tarazu During Drosophila Neurogenesis

1988 • 342 citations

Early events in insect neurogenesis

1985 • 339 citations

The embryonic development of Drosophila melanogaster

1986 • 339 citations

The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures.

1990 • 326 citations

Fates of visual cortical neurons in the ferret after isochronic and heterochronic transplantation

1988 • 311 citations

The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system.

1990 • 299 citations

Localization of the fushi tarazu protein during Drosophila embryogenesis

1985 • 290 citations

Embryogenesis of an insect nervous system:I. A map of the thoracic and abdominal neuroblasts inLocusta migratoria

1976 • 283 citations

slit: An EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system

1988 • 281 citations

The expression of three members of the achaete-scute gene complex correlates with neuroblast segregation in Drosophila

1987 • 272 citations

The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes.

1988 • 271 citations

Control of neuronal fate by the Drosophila segmentation gene even-skipped

1988 • 264 citations

Molecular genetics of the single-minded locus: A gene involved in the development of the Drosophila nervous system

1988 • 254 citations

Decapentaplegic transcripts are localized along the dorsal-ventral axis of the Drosophila embryo.

1987 • 247 citations

Zygotically active genes that affect the spatial expression of the fushi tarazu segmentation gene during early Drosophila embryogenesis

1986 • 242 citations

Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm

1986 • 242 citations

A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo.

1988 • 238 citations

The role of segment polarity genes during Drosophila neurogenesis.

1989 • 235 citations

Pathfinding by neuronal growth cones in grasshopper embryos. I. Divergent choices made by the growth cones of sibling neurons

1983 • 226 citations

Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brain.

1988 • 225 citations

Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes.

1987 • 220 citations

I-POU: a POU-domain protein that inhibits neuron-specific gene activation

1991 • 217 citations

Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis.

1987 • 213 citations

Serotonin‐containing neurons in Drosophila melanogaster: Development and distribution

1988 • 209 citations

Cell determination and differentiation of identified serotonin- immunoreactive neurons in the grasshopper embryo

1984 • 205 citations

The correct activation of Antennapedia and bithorax complex genes requires the fushi tarazu gene

1986 • 201 citations

Regulation of segment polarity genes in the Drosophila blastoderm by fushi tarazu and even skipped

1988 • 194 citations

A multifaceted approach to neural development

1989 • 194 citations

A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner.

1990 • 185 citations

Cross-Regulatory Interactions Among Pair-Rule Genes in Drosophila

1986 • 184 citations

Defective neuroblast commitment in mutants of the achaete-scute complex and adjacent genes of D. melanogaster

1990 • 174 citations

Competence to develop sensory organs is temporally and spatially regulated in Drosophila epidermal primordia.

1990 • 174 citations

Isolation of two tissue-specific Drosophila paired box genes, Pox meso and Pox neuro.

1989 • 161 citations

Lateral inhibition and cell fate during neurogenesis in Drosophila: the interactions between scute, Notch and Delta

1990 • 159 citations

Postembryonic neurogenesis in the CNS of the tobacco hornworm, Manduca sexta. I. Neuroblast arrays and the fate of their progeny during metamorphosis

1987 • 157 citations

Distribution and function of the lethal of scute gene product during early neurogenesis in Drosophila

1991 • 136 citations

The achaete-scute complex is expressed in neurogenic regions of Drosophila embryos

1987 • 129 citations

Temporal and spatial relationships between segmentation and homeotic gene expression in Drosophila embryos: distributions of the fushi tarazu, engrailed, Sex combs reduced, Antennapedia, and Ultrabithorax proteins.

1988 • 117 citations

Neuronal determination during embryonic development of the grasshopper nervous system

1985 • 113 citations

Direct cell lineage analysis in Drosophila melanogaster by time-lapse, three-dimensional optical microscopy of living embryos.

1989 • 102 citations

Two groups of interrelated genes regulate early neurogenesis in Drosophila melanogaster

1988 • 87 citations

Tissue- and stage-specific control of homeotic and segmentation gene expression in Drosophila embryos by the polyhomeotic gene

1988 • 86 citations

Drosophila fasciclin I, a neural cell adhesion molecule, has a phosphatidylinositol lipid membrane anchor that is developmentally regulated.

1990 • 85 citations

Segmentation and homeotic gene function in the developing nervous system of Drosophila

1988 • 84 citations

Drosophila embryonic neuroblasts in culture: Autonomous differentiation of specific neurotransmitters

1989 • 79 citations

Control of bithorax complex functions by the segmentation gene fushi tarazu of D. melanogaster

1986 • 78 citations

polyhomeotic: a gene required for the embryonic development of axon pathways in the central nervous system of Drosophila.

1988 • 76 citations

Mutant Drosophila embryos in which all cells adopt a neural fate

1989 • 52 citations

Complex spatio-temporal accumulation of alternative transcripts from the neurogenic geneDeltaduringDrosophilaembryogenesis

1989 • 44 citations

Cell-cell interactions that specify certain cell fates in C. elegans development

1989 • 39 citations

Molecular and cellular interactions responsible for intrasegmental patterning during Drosophila embryogenesis.

1990 • 22 citations

Octopod, a homeotic mutation of the moth Manduca sexta, influences the fate of identifiable pattern elements within the CNS

1989 • 15 citations