The pharmacology of native N-methtl-D-aspartate receptor subtypes: Different receptors control the release of different striatal and spinal transmitters

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.

1993 • 978 citations

Neuropharmacology of quinolinic and kynurenic acids.

1993 • 920 citations

Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.

1993 • 828 citations

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

1992 • 626 citations

Zinc potentiates agonist-lnduced currents at certain splice variants of the NMDA receptor

1993 • 605 citations

Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing

1992 • 521 citations

Evidence for spinal N-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

2016 • 516 citations

Relief of post-herpetic neuralgia with the Symbol receptor antagonist ketamine: A double-blind, cross-over comparison with morphine and placebo

1994 • 483 citations

The role of glutamate in epilepsy and other CNS disorders.

1994 • 476 citations

Evidence for spinalN-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

1990 • 458 citations

Alternatively spliced isoforms of the NMDARI receptor subunit

1995 • 450 citations

Ketamine activates psychosis and alters limbic blood flow in schizophrenia

1995 • 438 citations

The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor

1989 • 434 citations

Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain

1993 • 415 citations

Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA

1994 • 405 citations

Ligand affinities at recombinant receptors depend on subunit composition

1994 • 381 citations

The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition

1994 • 373 citations

Organization of N‐methyl‐D‐aspartate glutamate receptor gene expression in the basal ganglia of the rat

1994 • 368 citations

Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C.

1993 • 347 citations

Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.

1986 • 339 citations

NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum

1995 • 323 citations

Distinct distributions of five N‐methyl‐<scp>D</scp>‐aspartate receptor channel subunit mRNAs in the forebrain

1993 • 316 citations

Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C.

1992 • 309 citations

The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias

1995 • 306 citations

Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

1995 • 300 citations

Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors.

1992 • 284 citations

Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

1993 • 278 citations

Continuous subcutaneous administration of the N -methyl-D-aspartic acid (NMDA) receptor antagonist ketamine in the treatment of post-herpetic neuralgia

1995 • 263 citations

Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells.

1995 • 252 citations

ROLE OF NITRIC OXIDE IN NMDA-EVOKED RELEASE OF [3H]-DOPAMINE FROM STRIATAL SLICES

1992 • 249 citations

Excitatory amino acid antagonists

1991 • 240 citations

Dextromethorphan and neuromodulation: old drug coughs up new activities

1989 • 205 citations

The pharmacotherapy of focal cortical ischaemia in the mouse

1990 • 151 citations

Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neurons

1993 • 140 citations

Regional Variations in the Pharmacology of NMDA Receptor Channel Blockers: Implications for Therapeutic Potential

1995 • 137 citations

Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism.

1991 • 127 citations

Distinct presynaptic regulation of dopamine release through NMDA receptors in striosome- and matrix-enriched areas of the rat striatum

1991 • 121 citations

Stimulation of dopamine release by GABA in rat striatal slices

1978 • 109 citations

Muscle relaxant action of excitatory amino acid antagonists

1985 • 100 citations

Pharmacological properties of recombinant N-methyl-d-aspartate (NMDA) receptors containing the ϵ4 (NR2D) subunit

1995 • 100 citations

The glycine/NMDA receptor antagonist, R‐(+)‐HA‐966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK‐801) in rodents

1993 • 94 citations

Selective Release of Spermine and Spermidine from the Rat Striatum by N‐Methyl‐<scp>d</scp>‐Aspartate Receptor Activation In Vivo

1992 • 86 citations

Quinolinate differentiates between forebrain and cerebellar NMDA receptors

1991 • 81 citations

The clinically tested N-methyl-d-aspartate receptor antagonist memantine blocks and reverses thermal hyperalgesia in a rat model of painful mononeuropathy

1995 • 78 citations

Regional Variations in [³H]MK801 Binding to Rat Brain N‐Methyl‐D‐Aspartate Receptors

1991 • 77 citations

Localization of NMDA receptor subunit mRNAs in the rat locus coeruleus

1995 • 76 citations

Analysis of Drug Interaction between Intrathecal Clonidine and MK-801 in Peripheral Neuropathic Pain Rat Model

1995 • 75 citations

Effects of phencyclidine and other N-methyl-D-aspartate antagonists on the schedule-controlled behavior of rats.

1989 • 70 citations

Identification of a novel NMDA receptor in rat cerebellum

1991 • 70 citations

Recombinant Human NMDA Homomeric NR1 Receptors Expressed in Mammalian Cells Form a High‐Affinity Glycine Antagonist Binding Site

1995 • 68 citations

Identification of a Novel N‐Methyl‐D‐Aspartate Receptor Population in the Rat Medial Thalamus

1992 • 67 citations

Blockade by ifenprodil of high voltage‐activated Ca²⁺ channels in rat and mouse cultured hippocampal pyramidal neurones: comparison with N‐methyl‐D‐aspartate receptor antagonist actions

1994 • 63 citations

Chemically-diverse ligands at the glycine B site coupled to (NMDA) receptors selectively block the late phase of formalin-induced pain in mice

1994 • 62 citations

N-methyl-D-aspartate antagonism and phencyclidine-like activity: a drug discrimination analysis.

1990 • 61 citations

Molecular diversity of glutamate receptors and their physiological functions

1994 • 61 citations

Reversal of parkinsonian symptoms by intrastriatal and systemic manipulations of excitatory amino acid and dopamine transmission in the bilateral 6-OHDA lesioned marmoset

1995 • 59 citations

Cardiovascular effects of the N-methyl-D-aspartate receptor antagonist MK-801 in conscious rats.

1989 • 59 citations

Alternatively spliced isoforms of the NMDAR1 glutamate receptor subunit: Differential expression in the basal ganglia of the rat

1993 • 58 citations

Effects of NMDA receptor antagonists and sigma ligands on the acquisition of conditioned fear in mice

1991 • 57 citations

The glycine/NMDA receptor antagonist, L-701,324 reverses isolation-induced deficits in prepulse inhibition in the rat

1995 • 55 citations

Subunit‐specific block of cloned NMDA receptors by argiotoxin₆₃₆

1993 • 54 citations

Neuroprotection following focal cerebral ischaemia with the NMDA antagonist dextromethorphan, has a favourable dose response profile

1993 • 50 citations

A comparison of N-methyl-D-aspartate-evoked release of adenosine and [3H]norepinephrine from rat cortical slices.

1990 • 47 citations

N-Methyl-di-aspartate receptors modulate neurotransmitter release and peristalsis in the guinea pig isolated colon

1995 • 47 citations

Noncompetitive N-methyl-D-aspartate antagonists affect multiple ionic currents.

1988 • 42 citations

The anticonvulsant and behavioural profile of L‐687,414, a partial agonist acting at the glycine modulatory site on the N‐methyl‐D‐aspartate (NMDA) receptor complex

1994 • 41 citations

Antagonists of the NMDA receptor-channel complex and motor coordination

1995 • 37 citations

Modulation of GABA release by α-amino-3-hydroxy-5-methylisoxazole-4-propionate and N-methyl-d-aspartate receptors in matrix-enriched areas of the rat striatum

1992 • 36 citations

The NMDA receptor antagonist eliprodil (SL 82.0715) blocks voltage-operated Ca2+ channels in rat cultured cortical neurons

1994 • 32 citations

Solubilization of Rat Brain Phencyclidine Receptors in an Active Binding Form That Is Sensitive to N‐Methyl‐d‐Aspartate Receptor Ligands

1988 • 32 citations

Block of the N-methyl-d-aspartate receptor by phenycyclidine-like drugs is influenced by alternative splicing

1995 • 29 citations

NMDA Receptors with Different Sensitivities to Magnesium and Ifenprodil Control the Release of [¹⁴C]Acetylcholine and [³H]Spermidine from Rat Striatal Slices in Vitro

1994 • 28 citations

Phencyclidine-induced retrograde amnesia in mice

1986 • 27 citations

Developmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil

1992 • 27 citations

Effects of TCP on Spatial Memory: Comparison with MK-801

1995 • 27 citations

Striatal NMDA receptor subtypes: the pharmacology of N-methyl-d-aspartate-evoked dopamine, γ-aminobutyric acid, acetylcholine and spermidine release

1995 • 27 citations

Competitive NMDA receptor antagonists attenuate the behavioural and neurochemical effects of amphetamine in mice

1994 • 25 citations

A splice variant of the (NMDAR1) receptor

1993 • 23 citations

NMDA Receptor Subtype Selectivity: Eliprodil, Polyamine Spider Toxins, Dextromethorphan, and Desipramine Selectively Block NMDA‐Evoked Striatal Acetylcholine but Not Spermidine Release

1995 • 22 citations

The effects of NMDA antagonists on punished exploration in mice

1991 • 21 citations

NMDA and Non‐NMDA Receptor‐Mediated Release of [³H]GABA from Granule Cell Dendrites of Rat Olfactory Bulb

1995 • 20 citations

Effects of D-cycloserine and (+)-HA-966 on the locomotor stimulation induced by NMDA antagonists and clonidine in monoamine-depleted mice

1994 • 16 citations

Pharmacological heterogeneity of NMDA receptors in cerebellar granule cells in immature rat slices. A microfluorimetric study with the [Ca2+]i sensitive dye indo-1

1995 • 14 citations

Noradrenaline but not dopamine involved in NMDA receptor-mediated hyperalgesia induced by theophylline in awake rats

1994 • 14 citations

Pharmacologically-distinct NMDA receptor populations of the cerebellum, medial thalamic nuclei and forebrain

1992 • 12 citations

Pharmacology of N-methyl-d-aspartate-evoked [3H]noradrenaline release in adult rat spinal cord

1996 • 11 citations

Block of P-type Ca2+ channels by the NMDA receptor antagonist eliprodil in acutely dissociated rat Purkinje cells

1995 • 10 citations

Differential neuropsychopharmacological profiles of NMDA antagonists: Ifenprodil-like, PCP-like and CPP-like compounds

1990 • 8 citations

Alternative approaches to the discovery of novel antipsychotic agents

1992 • 8 citations

Modulation of NMDA receptor - mediated release of [3H]arachidonate in hippocampal slices of immature rats

1995 • 6 citations