Disruption of α3 Connexin Gene Leads to Proteolysis and Cataractogenesis in Mice

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

The Gap Junction Communication Channel

1996 • 1,896 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Connections with Connexins: the Molecular Basis of Direct Intercellular Signaling

1996 • 1,301 citations

Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes.

1991 • 600 citations

The role of proteases during apoptosis

1996 • 558 citations

Physiological properties of the normal lens

1997 • 393 citations

Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals.

1995 • 384 citations

The Lens: Development, Proteins, Metabolism and Cataract

1984 • 342 citations

Targeted disruption of the mouse αA-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein αB-crystallin

1997 • 332 citations

Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70.

1992 • 332 citations

Mutations in the founder of the MIP gene family underlie cataract development in the mouse

1996 • 266 citations

Molecular and cellular biology of the eye lens

1981 • 256 citations

A beta-galactosidase hybrid protein targeted to nuclei as a marker for developmental studies.

1987 • 232 citations

The crystalline lens. A system networked by gap junctional intercellular communication

1992 • 222 citations

The structural organization and protein composition of lens fiber junctions.

1989 • 216 citations

Chromatin Degradation in Differentiating Fiber Cells of the Eye Lens

1997 • 187 citations

In Situ Detection of β-Galactosidase in Lenses of Transgenic Mice with a γ-Crystallin/ lacZ Gene

1987 • 137 citations

Spatial and temporal patterns of distribution of the gap junction protein connexin43 during mouse gastrulation and organogenesis

1992 • 129 citations

Cellular and molecular features of lens differentiation: a review of recent advances

1996 • 128 citations

Evidence that α-crystallin prevents non-specific protein aggregation in the intact eye lens

1995 • 128 citations

[28] Application of LacZ gene fusions to postimplantation development

1993 • 125 citations

Distribution of gap junctions and square array junctions in the mammalian lens.

1989 • 122 citations

Review of selenite cataract

1992 • 121 citations

Localization of steady currents in the lens

1982 • 110 citations

Processing of the gap junction protein connexin50 in the ocular lens is accomplished by calpain.

1997 • 105 citations

Molecular and Cellular Biology of the Eye Lens

1982 • 105 citations

Dye Transfer Between Cells of the Lens

1996 • 93 citations

Calcium, cell signalling and cataract

1994 • 91 citations

Developmental Regulation and Structural Organization of Connexins in Epidermal Gap Junctions

1994 • 84 citations

Activation of the ΓE-crystallin pseudogene in the human hereditary Coppock-like cataract

1994 • 84 citations

Purification of calpain II from rat lens and determination of endogenous substrates

1986 • 84 citations

Rat lens γ-crystallins

1988 • 76 citations

Conversion of the substrate specificity of mouse proteinase granzyme B

1994 • 74 citations

A New Locus for Dominant “Zonular Pulverulent” Cataract, on Chromosome 13

1997 • 66 citations

Ubiquitin and ubiquitin conjugates in human lens

1992 • 62 citations

Liquefaction of cortical tissue in diabetic and galactosemic rat lenses defined by confocal laser scanning microscopy.

1996 • 62 citations

Calcium-induced opacification and proteolysis in the intact rat lens.

1990 • 60 citations

Changes in Connexin Expression and Distribution During Chick Lens Development

1995 • 60 citations

Distribution and Type of Morphological Damage in Human Nuclear Age-Related Cataracts

1996 • 50 citations

The degradation of alpha-crystallin at its carboxyl-terminal portion by calpain in bovine lens.

1986 • 36 citations

Human multidrug resistance 3-P-glycoprotein expression in transgenic mice induces lens membrane alterations leading to cataract.

1996 • 35 citations

DNA strand breakage during physiological apoptosis of the embryonic chick lens: Free 3' OH end single strand breaks do not accumulate even in the presence of a cation‐independent deoxyribonuclease

1994 • 31 citations

Gap junction formation during development of the mouse lens.

1993 • 28 citations

Age-related changes of calpain II and α-crystallin in the lens of hereditary cataract (Nakano) mouse

1985 • 26 citations

Cysteine Protease Activated by Expression of HIV-1 Protease in Transgenic Mice

1996 • 22 citations

Alterations in fiber cell membranes of Emory mouse cataract: A morphologic study

1987 • 19 citations

Characterization of Three Isoforms of a 9kDa γD-Crystallin Fragment Isolated From Human Lenses

1996 • 15 citations

The developmental expression of three mammalian lens fiber cell membrane proteins.

1993 • 9 citations