Human multidrug resistance 3-P-glycoprotein expression in transgenic mice induces lens membrane alterations leading to cataract.

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Requirement of Human Renal Water Channel Aquaporin-2 for Vasopressin-dependent Concentration of Urine

1994 • 870 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia.

1993 • 761 citations

Mammalian Membrane-bound Adenylyl Cyclases

1995 • 722 citations

Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules.

1988 • 669 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

1990 • 386 citations

Antibodies to intermediate filament proteins in the immunohistochemical identification of human tumours: an overview

1983 • 324 citations

Aquaporins: water channel proteins of plant and animal cells

1994 • 304 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

The human MDR3 P‐glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

1994 • 278 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Water Channel Properties of Major Intrinsic Protein of Lens

1995 • 248 citations

Tetrameric assembly of CHIP28 water channels in liposomes and cell membranes: a freeze-fracture study.

1993 • 238 citations

Molecular biology and genetics of gap junction channels

1992 • 225 citations

The crystalline lens. A system networked by gap junctional intercellular communication

1992 • 222 citations

Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies.

1991 • 212 citations

Protein Involvement in Transmembrane Lipid Asymmetry

1992 • 200 citations

Tissue distribution of the human MDR3 P-glycoprotein.

1994 • 153 citations

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance.

1992 • 140 citations

Overexpression of the vimentin gene in transgenic mice inhibits normal lens cell differentiation.

1989 • 139 citations

Distribution of gap junctions and square array junctions in the mammalian lens.

1989 • 122 citations

Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA.

1990 • 121 citations

Multidrug resistance mediated by P-glycoproteins.

1991 • 113 citations

Deletion mutation in an eye lens beta-crystallin. An animal model for inherited cataracts.

1991 • 106 citations

Square arrays and their role in ridge formation in human lens fibers

1984 • 99 citations

Development of Junctions During Differentiation of Lens Fibers

1974 • 98 citations

Lens gap junctions and orthogonal arrays are unrelated

1980 • 85 citations

Aquaporins: water selective channels in biological membranes. Molecular structure and tissue distribution

1994 • 80 citations

Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genes.

1991 • 77 citations

Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P‐glycoprotein

1993 • 74 citations

Two Members of the Mouse mdr Gene Family Confer Multidrug Resistance with Overlapping but Distinct Drug Specificities

1990 • 69 citations

Electron microscopic observations of reconstituted proteoliposomes with the purified major intrinsic membrane protein of eye lens fibers.

1987 • 62 citations

Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects

1992 • 61 citations

Cytological study of philly mouse cataract

1980 • 60 citations

Plasma membrane-cytoskeleton damage in eye lenses of transgenic mice expressing desmin.

1990 • 59 citations

A possible cataractogenic factor in the Nakano mouse lens

1978 • 56 citations

Lipid composition of lens plasma membrane fractions enriched in fiber junctions.

1991 • 53 citations

Differential synthesis and degradation of protein in the hereditary Philly mouse cataract

1980 • 49 citations

Proctor lecture. Disorganization of membranes and abnormal intermediate filament assembly lead to cataract.

1991 • 49 citations

Cloning and Characterization of a Second Member of the Mouse mdr Gene Family

1988 • 45 citations

Cytokeratin expression and early lens development

1992 • 44 citations

Transgenic expression of the muscle-specific intermediate filament protein desmin in nonmuscle cells.

1989 • 42 citations

Regulation of vimentin gene expression in the ocular lens

1990 • 39 citations

Regional distribution of lipids and phospholipase A₂activity in normal and cataractous rat lens

1985 • 39 citations

A gene location for the inheritance of the Cataract Fraser (Cat^Fr) mouse congenital cataract

1987 • 38 citations

Animal models for the study of maturity-onset and hereditary cataract

1990 • 38 citations

Aberrant expression of the gene for lens major intrinsic protein in the CAT mouse

1993 • 33 citations

Hereditary cataract of the Nakano mouse

1990 • 31 citations

Genetical and biochemical studies of a dominant cataract mutant in mice

1984 • 30 citations

Rodent models of congenital and hereditary cataract in man.

1991 • 29 citations

Calcium Activated Proteolysis and Protein Modification in the U18666A Cataract

1993 • 25 citations

Analysis of lens protein synthesis in a cataractous mutant mouse: The Cat Fraser

1990 • 22 citations

Alterations in fiber cell membranes of Emory mouse cataract: A morphologic study

1987 • 19 citations

Catalytic subunit isoforms of mammalian lens Na, K-ATPase

1994 • 18 citations

High‐performance liquid chromatography of the main polypeptide (MP26) of lens fiber plasma membranes solubilized with n‐octyl β‐D‐glucopyranoside

1988 • 17 citations

Immunochemical comparison of the major intrinsic protein of eye-lens fibre cell membranes in mice with hereditary cataracts

1991 • 14 citations

Alterations of Urea-Insoluble Membrane Fraction, MP26, of Emory Mouse Lenses in Aging and Cataractogenesis

1990 • 12 citations

Does MIP play a role in cell–cell communication?

1993 • 12 citations

Lens-specific expression of a major histocompatibility complex class I molecule disrupts normal lens development and induces cataracts in transgenic mice.

1995 • 11 citations

Functional Analysis of Chimeric Genes Obtained by Exchanging Homologous Domains of the Mouse mdr1 and mdr2 Genes

1991 • 9 citations

Na,K-ATPases of the Lens Epithelium and Fiber Cell: Formation of Catalytic Cycle Intermediates and Na+:K+ exchange

1994 • 8 citations

Biochemical and Structural Properties of the Protein Constituent of Junctional Domains in Eye Lens Fiber Plasma Membranes

1990 • 7 citations

Restriction fragment length polymorphisms associated with the gene for the major intrinsic protein of eye-lens fibre cell membranes in mice with hereditary cataracts

1991 • 6 citations

Changes in lens proteins induced at the early stage of cataractogenesis in cac (Nakano) mice

1989 • 5 citations

GAP Junctional Communication During Mouse Development

1992 • 4 citations