Thrombolysis and Stroke

Thresholds in cerebral ischemia - the ischemic penumbra.

1981 • 2,780 citations

Prevalence of Total Coronary Occlusion during the Early Hours of Transmural Myocardial Infarction

1980 • 2,722 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Thrombosis and Acute Coronary-Artery Lesions in Sudden Cardiac Ischemic Death

1984 • 1,700 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Increased Plasma Levels of a Rapid Inhibitor of Tissue Plasminogen Activator in Young Survivors of Myocardial Infarction

1985 • 1,364 citations

The Harvard Cooperative Stroke Registry

1978 • 1,180 citations

On the Regulation and Control of Fibrinolysis

1980 • 1,139 citations

MOOD DISORDERS IN STROKE PATIENTS: IMPORTANCE OF LOCATION OF LESION

1984 • 1,079 citations

Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death

1984 • 893 citations

Comparative pharmacology of calcium antagonists: Nifedipine, verapamil and diltiazem

1980 • 865 citations

Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system

1971 • 808 citations

RANDOMISED TRIAL OF INTRAVENOUS RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR VERSUS INTRAVENOUS STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION

1985 • 756 citations

Correlation of Cerebral Blood Flow and Electroencephalographic Changes during Carotid Endarterectomy, with Results of Surgery and Hemodynamics of Cerebral Ischemia

1982 • 706 citations

HÆMOSTATIC FUNCTION AND CARDIOVASCULAR DEATH: EARLY RESULTS OF A PROSPECTIVE STUDY

1980 • 704 citations

Mechanism of Action of Calcium-Channel-Blocking Agents

1982 • 692 citations

Multicenter trial of hemodilution in ischemic stroke--background and study protocol. Scandinavian Stroke Study Group.

1985 • 681 citations

The pathophysiology of brain ischemia

1983 • 637 citations

Free radicals in cerebral ischemia.

1978 • 589 citations

Cerebrovascular Complications in Patients with Cancer

1985 • 587 citations

THE MECHANISM OF CLOT DISSOLUTION BY PLASMIN*

1959 • 581 citations

EVALUATION OF CEREBRAL PERFUSION RESERVE IN PATIENTS WITH CAROTID-ARTERY OCCLUSION

1984 • 576 citations

Calcium Channel Blocking Agents in the Treatment of Cardiovascular Disorders. Part II: Hemodynamic Effects and Clinical Applications

1980 • 551 citations

Early mortality following stroke: a prospective review.

1984 • 484 citations

Correlation of Continuous Electroencephalograms With Cerebral Blood Flow Measurements During Carotid Endarterectomy

1973 • 474 citations

IMPROVED SURVIVAL AFTER EARLY THROMBOLYSIS IN ACUTE MYOCARDIAL INFARCTION

1985 • 450 citations

The Regulation of Hemostasis: The Protein C System

1986 • 443 citations

Characteristics affecting fibrinolytic activity and plasma fibrinogen concentrations.

1979 • 426 citations

SERIAL OBSERVATIONS ON THE PATHOPHYSIOLOGY OF ACUTE STROKE

1983 • 424 citations

Fibrinolytic properties of one-chain and two-chain human extrinsic (tissue-type) plasminogen activator.

1982 • 415 citations

GLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS

1971 • 409 citations

Energy-requiring cell functions in the ischemic brain

1982 • 408 citations

Functional recovery of cortical neurons as related to degree and duration of ischemia

1983 • 396 citations

Coronary thrombolysis with recombinant human tissue-type plasminogen activator: a prospective, randomized, placebo-controlled trial.

1984 • 387 citations

Brain injury, edema, and vascular permeability changes induced by oxygen‐derived free radicals

1984 • 387 citations

Prevention of Myocardial Damage in Acute Myocardial Ischemia by Early Treatment with Intravenous Streptokinase

1985 • 382 citations

Recovery of brain mitochondrial function in the rat after complete and incomplete cerebral ischemia.

1979 • 379 citations

Tissue Plasminogen Activator Reduces Neurological Damage After Cerebral Embolism

1985 • 369 citations

Coronary Thrombolysis with Tissue-Type Plasminogen Activator in Patients with Evolving Myocardial Infarction

1984 • 362 citations

Evidence for the Occurrence of a Fast-Acting Inhibitor for Tissue-Type Plasminogen Activator in Human Plasma

1984 • 345 citations

Randomized clinical study of thiopental loading in comatose survivors of cardiac arrest

1987 • 338 citations

Lipoprotein(a) as a strong indicator for cerebrovascular disease.

1986 • 335 citations

Hemorrhagic cerebral infarction--a prospective study.

1986 • 333 citations

Calcium Channel Blocking Agents in the Treatment of Cardiovascular Disorders. Part I: Basic and Clinical Electrophysiologic Effects

1980 • 332 citations

Rethrombosis after reperfusion with streptokinase: importance of geometry of residual lesions.

1984 • 322 citations

Observations on brain embolism with special reference to the mechanism of hemorrhagic infarction.

1950 • 321 citations

Plasminogen activator inhibitor in the blood of patients with coronary artery disease.

1985 • 311 citations

Activated protein C decreases plasminogen activator-inhibitor activity in endothelial cell-conditioned medium

1985 • 305 citations

Immediate anticoagulation of embolic stroke: a randomized trial. Cerebral Embolism Study Group.

1983 • 303 citations

Acute coronary reocclusion after thrombolysis with recombinant human tissue-type plasminogen activator: prevention by a maintenance infusion.

1986 • 302 citations

The Role of Glutamate in Neurotransmission and in Neurologic Disease

1986 • 294 citations

Blood flow and vascular reactivity in collaterally perfused brain tissue. Evidence of an ischemic penumbra in patients with acute stroke.

1983 • 290 citations

Immediate anticoagulation of embolic stroke: brain hemorrhage and management options. Cerebral Embolism Study Group.

1984 • 267 citations

Anticoagulant therapy in cerebral infarction

1962 • 263 citations

Positron emission tomography and its application to the study of cerebrovascular disease in man.

1985 • 260 citations

Physiological responses to focal cerebral ischemia in humans

1984 • 258 citations

Cerebral embolism in the Michael Reese Stroke Registry.

1983 • 247 citations

Whole blood viscosity parameters and cerebral blood flow.

1982 • 247 citations

Plasma levels of a specific inhibitor of tissue-type plasminogen activator (and urokinase) in normal and pathological conditions

1984 • 240 citations

Cerebral Hyperperfusion after Carotid Endarterectomy: A Cause of Cerebral Hemorrhage

1984 • 233 citations

A pilot study of urokinase therapy in cerebral infarction.

1976 • 222 citations

Fibrinolysis with acyl-enzymes: a new approach to thrombolytic therapy

1981 • 217 citations

Thrombolytic therapy in stroke: possibilities and hazards.

1986 • 216 citations

Experimental ischemic stroke: a review.

1984 • 213 citations

Tissue Plasminogen Activator: Chemical and Physiological Aspects

1984 • 210 citations

NALOXONE REVERSAL OF ISCHAEMIC NEUROLOGICAL DEFICITS IN MAN

1981 • 208 citations

Thrombolytic Therapy

1984 • 208 citations

Flow thresholds of functional and morphological damage of brain tissue.

1983 • 207 citations

Anticoagulant‐related intracerebral hemorrhage

1985 • 207 citations

THROMBOLYSIS WITH FIBRINOLYSIN IN CEREBRAL ARTERIAL OCCLUSION

1958 • 205 citations

Prostaglandin I2 and indomethacin prevent impairment of post-ischemic brain reperfusion in the dog.

1979 • 202 citations

Lipoprotein(a) as a strong indicator for cerebrovascular disease.

1986 • 201 citations

Congenital Deficiency of α2-Plasmin Inhibitor Associated with Severe Hemorrhagic Tendency *

1979 • 201 citations

Protein-C: biochemistry, physiology, and clinical implications

1983 • 194 citations

The decline of stroke.

1984 • 187 citations

Cerebral Blood Flow and Neurologic Outcome When Nimodipine is Given after Complete Cerebral Ischemia in the Dog

1984 • 177 citations

Thrombolytic therapy in the eighties

1986 • 177 citations

Cardiopulmonary Cerebral Resuscitation.

1982 • 177 citations

Effect of pretreatment with the calcium antagonist nimodipine on local cerebral blood flow and histopathology after middle cerebral artery occlusion

1985 • 173 citations

Hemorheology of the cerebral circulation in stroke.

1985 • 172 citations

Calcium-Antagonist Drugs

1985 • 172 citations

Cerebral Hemorrhage in Carotid Artery Surgery

1963 • 159 citations

LOCALIZATION OF FIBRINOLYTIC ACTIVITY IN TISSUES

1964 • 157 citations

Delayed postischemic hypoperfusion

1979 • 155 citations

The role of postischemic recirculation in the development of ischemic neuronal injury following complete cerebral ischemia

1981 • 151 citations

EARLY AND LATE MECHANISMS OF INCREASED VASCULAR PERMEABILITY FOLLOWING EXPERIMENTAL CEREBRAL INFARCTION

1979 • 144 citations

Correlation between rCBF and histological changes following temporary middle cerebral artery occlusion.

1980 • 144 citations

The effects of nimodipine on the clinical course of patients with acute ischemic stroke

1984 • 143 citations

Biological and Thrombolytic Properties of Proenzyme and Active Forms of Human Urokinase – I. Fibrinolytic and Fibrinogenolytic Properties in Human Plasma In Vitro of Urokinases Obtained from Human Urine or by Recombinant DNA Technology

1984 • 141 citations

Intracerebral hemorrhage following carotid endarterectomy: a hypertensive complication?

1978 • 139 citations

Inhibitors of the Fibrinolytic Enzyme System

1984 • 138 citations

Blood Fibrinolytic Activity in Diabetes Mellitus and Its Bearing on Ischaemic Heart Disease and Obesity

1963 • 136 citations

THE RELATIONSHIP BETWEEN CBF, EVOKED POTENTIALS AND THE CLINICAL FEATURES IN CEREBRAL ISCHAEMIA

1980 • 132 citations

Cerebral hemorrhagic infarction at autopsy: cardiac embolic cause and the relationship to the cause of death.

1986 • 127 citations

Randomized comparison of intravenous versus intracoronary streptokinase for myocardial infarction

1984 • 127 citations

Focal cerebral hyperemia in acute stroke. Incidence, pathophysiology and clinical significance.

1981 • 117 citations

Vascular recanalizing techniques in interventional neuroradiology

1985 • 115 citations

Biology and therapeutic potential of prostacyclin.

1983 • 113 citations

Brain Ischemic Anoxia

1984 • 110 citations

PROGNOSIS OF CEREBRAL EMBOLISM

1965 • 110 citations

Hypertension in Acute Ischemic Strokes

1985 • 108 citations

The beneficial effect of intracarotid urokinase on acute stroke in a baboon model.

1986 • 105 citations

Angiographic manifestations in postrecanalized cerebral infarction

1977 • 103 citations

Streptokinase in acute myocardial infarction: a controlled multicentre study in the United Kingdom.

1976 • 97 citations

Biological and Thrombolytic Properties of Proenzyme and Active Forms of Human Urokinase – III. Thrombolytic Properties of Natural and Recombinant Urokinase in Rabbits with Experimental Jugular Vein Thrombosis

1984 • 96 citations

The clinical spectrum of hemorrhagic infarction.

1986 • 93 citations

FIBRINOLYTIC EFFECTS OF DIGUANIDES PLUS ETHYLŒSTRENOL IN OCCLUSIVE VASCULAR DISEASE

1967 • 93 citations

Thrombolysis, clot selectivity, and kinetics.

1984 • 92 citations

Clinical pharmacology in patients with evolving myocardial infarction of tissue-type plasminogen activator produced by recombinant DNA technology.

1985 • 92 citations

Anticoagulants Plus Streptokinase Therapy in Progressive Stroke

1964 • 86 citations

Fibrinolytic Enhancement by Stanozolol: A Double Blind Trial

1972 • 85 citations

Thrombolytic Therapy for Thromboembolism of Vertebrobasilar Artery

1983 • 85 citations

Transient Focal Ischemia in Subhuman Primates

1983 • 85 citations

Evaluation of the risk of immediate anticoagulant treatment in patients with embolic stroke of cardiac origin.

1983 • 85 citations

Successful Warfarin Anticoagulation Despite Protein C Deficiency and a History of Warfarin Necrosis

1986 • 84 citations

Urokinase Pulmonary Embolism Trial

1971 • 83 citations

CT-detected hemorrhagic infarction; relation with the size of the infarct, and the presence of midline shift

2009 • 82 citations

Sequential computerized tomographic appearance of strokes.

1983 • 81 citations

Temporary Regional Cerebral Ischemia in the Cat

1977 • 81 citations

Cerebral infarct in apparent transient ischemic attack

1985 • 80 citations

The source of 'paradoxical lateralization' of cortical evoked potentials to posterior tibial nerve stimulation

1987 • 77 citations

Anticoagulant-related hemorrhage in acute cerebral embolism.

1984 • 77 citations

Coronary thrombolysis in dogs with intravenously administered human pro-urokinase.

1985 • 77 citations

Failure of flunarizine to improve cerebral blood flow or neurologic recovery in a canine model of complete cerebral ischemia.

1984 • 76 citations

The effects of a calcium antagonist (nimodipine) on basal cerebral blood flow and reactivity to various agonists.

1984 • 75 citations

Eicosapentaenoic acid: effect on brain prostaglandins, cerebral blood flow and edema in ischemic gerbils.

1984 • 74 citations

Baseline hemodynamic state and response to hemodilution in patients with acute cerebral ischemia.

1985 • 72 citations

A double blind trial of naloxone in the treatment of acute stroke.

1984 • 71 citations

Dose-dependent thrombolysis, pharmacokinetics and hemostatic effects of recombinant human tissue-type plasminogen activator for coronary thrombosis

1986 • 71 citations

Coronary thrombolysis and infarct size reduction after intravenous infusion of recombinant tissue-type plasminogen activator in nonhuman primates.

1985 • 70 citations

Cerebral angiography in acute cerebral infarction.

1977 • 69 citations

Emotional problems after stroke.

1984 • 69 citations

Cerebrovascular Complications of Streptokinase Infusion

1985 • 69 citations

Stroke rehabilitation units: concepts, evaluation, and unresolved issues.

1985 • 68 citations

Naloxone therapy during focal cerebral ischemia evaluation in a primate model.

1984 • 66 citations

Biological and Thrombolytic Properties of Proenzyme and Active Forms of Human Urokinase – II. Turnover of Natural and Recombinant Urokinase in Rabbits and Squirrel Monkeys

1984 • 66 citations

Studies of Coagulation and Fibrinolysis of the Arterial and Venous Blood in Normal Subjects and Patients with Atherosclerosis

1963 • 66 citations

Pathophysiology of ischemic cell death: I. Time of onset of irreversible damage; importance of the different components of the ischemic insult.

1983 • 66 citations

Physiologic and Pharmacologic Enhancement of Fibrinolysis

1984 • 65 citations

Cerebral Embolism

1959 • 64 citations

Computed tomography of cerebral infarction: Hemorrhagic, contrast enhancement, and time of appearance

1977 • 63 citations

Blood coagulation and plasma fibrinolytic enzyme system pathophysiology in stroke.

1976 • 62 citations

The role of plasma lipids in carotid bifurcation atherosclerosis

1985 • 62 citations

A dose-escalation study of large doses of naloxone for treatment of patients with acute cerebral ischemia.

1986 • 61 citations

Effects of early intracoronary streptokinase on infarct size estimated from cumulative enzyme release and on enzyme release rate: A randomized trial of 533 patients with acute myocardial infarction

1986 • 61 citations

Factor VIII related antigen, antithrombin III, spontaneous platelet aggregation and plasminogen activator in ischemic cerebrovascular disease

1979 • 59 citations

The treatment of cerebrovascular thromboses and embolism with fibrinolytic agents

1960 • 56 citations

Cerebral infarction with transient signs (CITS): do TIAs correspond to small deep infarcts in internal carotid artery occlusion?

1984 • 56 citations

Fibrinogen, blood viscosity, and cerebral ischemia.

1985 • 55 citations

Randomized double-blind trial of intravenous streptokinase for acute myocardial infarction

1986 • 54 citations

Activation of coagulation and fibrinolytic systems following stroke

1983 • 54 citations

Neuronal survival and revival during and after cerebral ischemia

1983 • 52 citations

Conversion of Ischemic to Hemorrhagic Infarction by Anticoagulant Administration

1983 • 52 citations

Delayed high dose contrast CT: identifying patients at risk of massive hemorrhagic infarction

1981 • 51 citations

Failure of naloxone to reverse Vascular neurologic deficits

1983 • 47 citations

Stroke-in-progression.

1985 • 47 citations

Triglyceride-Rich Lipoproteins Are Responsible for Thrombin Generation Induced by Lipid Peroxides

1984 • 46 citations

The assessment of contractile reserve after thrombolytic therapy for acute myocardial infarction

1986 • 46 citations

A study of hemostasis in ischemic cerebrovascular disease I. Abnormalities in factor VIII and antithrombin

1982 • 45 citations

Monitoring activity of fibrinolytic agents

1984 • 44 citations

Treatment of acute focal cerebral ischemia with prostacyclin.

1983 • 43 citations

Stroke and Blood Coagulation

1973 • 39 citations

Neuropeptides and stroke: current status and potential application.

1983 • 39 citations

Opiate antagonists in the treatment of stroke.

1984 • 38 citations

Double-blind controlled trial of the therapeutic effects of prostacyclin in patients with completed ischaemic stroke.

1985 • 38 citations

Stroke-in-progression.

1985 • 38 citations

Calcium antagonist PY 108-068: demonstration of its efficacy in various types of experimental brain ischemia.

1984 • 37 citations

The Role of Fibrinolysis in Disease Processes

1984 • 37 citations

Abnormalities in Clotting and Thrombolysis as a Risk Factor for Stroke

1974 • 36 citations

A study of hemostasis in ischemic cerebrovascular disease III. Abnormalities in vascular plasminogen activators, antiactivators and α2-antiplasmin

1982 • 36 citations

Pathophysiology of ischemic cell death: II. Changes in plasma membrane permeability and cell volume.

1983 • 36 citations

Evidence for Abnormalities in Clotting and Thrombolysis as a Risk Factor For Stroke

1973 • 34 citations

FIBRINOLYTIC AND DEFIBRINATING EFFECT OF PHENFORMIN PLUS ETHYLŒSTRENOL IN VIVO

1969 • 32 citations

Plasma betathromboglobulin and serum fragment E in acute partial stroke

1982 • 32 citations

A Study of Blood Coagulation Following an Acute Stroke

1971 • 31 citations

Pathophysiology of ischemic cell death: III. Role of extracellular factors.

1983 • 31 citations

Relations between Activation and Inhibition of Fibrinolysis in the Walls of Human Arteries and Veins

1977 • 29 citations

Clinical Predictors of Outcome in Ischemic Stroke

1983 • 29 citations

Naloxone ameliorates the pathophysiologic changes which lead to and attend an acute stroke in stroke-prone/SHR.

1984 • 28 citations

Hemodilution in acute stroke.

1985 • 28 citations

Thromboelastographic Studies in Cerebral Infarction

1974 • 27 citations

Venous and arterial thromboembolic disease in women using oral contraceptives

1982 • 25 citations

Effect of ethyloestrenol on fibrinolysis in the vessel wall.

1976 • 25 citations

Special Problems Associated With Surgical and Thrombolytic Treatment of Strokes

1966 • 25 citations

The effect of intramuscular stanozolol on fibrinolysis and blood lipids

1982 • 24 citations

Effects of Naloxone on Canine Cerebral Vascular Smooth Muscle

1984 • 24 citations

OBSERVATIONS ON ANTICOAGULANT THERAPY IN THROMBOEMBOLIC DISEASE OF THE BRAIN.

1964 • 23 citations

Decreased incidence and mortality of stroke.

1984 • 23 citations

Cerebral resuscitation after cardiac arrest: Summaries and suggestions

1983 • 23 citations

Quantitation of Fibrinolytic Activity in Venous and Prosthetic Arterial Grafts

1974 • 22 citations

EFFECTS OF PLASMA LIPIDS ON FIBRINOLYSIS

1964 • 22 citations

Haemostatic studies in retinal vein occlusion. Fibrinolytic response to venostasis as a prognostic factor for spontaneous recanalization

1981 • 22 citations

Lysis of Intracerebral Thromboembolism With Fibrinolysin

1964 • 21 citations

Altered Endogenous Fibrinolysis and Biochemical Factors in Atherosclerosis

1974 • 19 citations

Releasable vascular plasminogen activator and thrombotic strokes

1985 • 19 citations

Serum lipids, platelets, and fibrinolytic activity in cerebrovascular disease.

1978 • 18 citations

Intracoronary thrombolysis in acute myocardial infarction: Clinical course following successful myocardial reperfusion

1984 • 18 citations

A basic study on the global coagulation and fibrinolysis of hyperlipaemic and atherosclerotic patients

1970 • 17 citations

[Indications for the use of thrombolytics in cases of cerebrovascular thrombosis also treated with hyperbaric oxygenation (2 ATA)].

1977 • 17 citations

Usefulness of residual plasma fibrinogen after intravenous streptokinase for predicting delay or failure of reperfusion in acute myocardial infarction

1986 • 16 citations

Naloxone ameliorates the pathophysiologic changes which lead to and attend an acute stroke in stroke-prone/SHR.

1984 • 16 citations

Fibrinolysis in Grafted Arteries and Veins

1978 • 14 citations

Diagnosis of reversible versus irreversible cerebral ischemia by the intravenous administration of naloxone.

1985 • 14 citations

Fibrinolytic Activity in Human Atherosclerotic Coronary Arteries

1967 • 14 citations

Understanding stroke and its rehabilitation.

1983 • 13 citations

A Study of Patients with Atherosclerosis and Renal Disease with Respect to Lipoprotein Types, Fibrinolysis, and Carbohydrate Tolerance

1972 • 12 citations

CEREBRAL PROTECTION DURING CAROTID ENDARTERECTOMY

1967 • 12 citations

Increased releasable vascular plasminogen activator and a bleeding diathesis

1984 • 9 citations

Identification of Individuals With Covert Ischemic Thrombotic Cerebrovascular Disease: A Discriminant Function Analysis

1972 • 9 citations

A basic study on the global coagulation and fibrinolysis of hyperlipaemic and atherosclerotic patients

1970 • 8 citations

Familial vascular plasminogen activator deficiency: a cause of cerebrovascular thrombosis.

1979 • 6 citations

In Vitro Effects of Lipids on Fibrinolysis

1973 • 4 citations

[Fibrinolytic activity and coronary heart disease].

1987 • 4 citations

Contrast enhancement CT scan and post-endarterectomy hemorrhage.

1986 • 3 citations

Angiographical extravasation of contrast medium in hemorrhagic infarction. Case report.

1976 • 3 citations

Deleted Work

1955 • 0 citations