Comparative pharmacology of calcium antagonists: Nifedipine, verapamil and diltiazem

Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth Muscle

1977 • 1,745 citations

Verapamil

1978 • 829 citations

Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors

1972 • 602 citations

Circadian variation of exercise capacity in patients with Prinzmetal's variant angina: role of exercise-induced coronary arterial spasm.

1979 • 506 citations

Existence and role of a slow inward current during the frog atrial action potential

1969 • 449 citations

Gating currents and charge movements in excitable membranes

2006 • 405 citations

Brief Reviews Exchange of Calcium Ions in the Mammalian Myocardium

1974 • 350 citations

Ionic channels in excitable membranes. Current problems and biophysical approaches

1978 • 326 citations

Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers.

1975 • 320 citations

Coronary arterial spasm and Prinzmetal's variant form of angina induced by hyperventilation and Tris-buffer infusion.

1978 • 304 citations

Myocardial contracture and accumulation of mitochondrial calcium in ischemic rabbit heart

1977 • 296 citations

Factors controlling cytoplasmic Ca ²⁺ concentration

1973 • 261 citations

Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium

1975 • 258 citations

Exertional angina pectoris caused by coronary arterial spasm: Effects of various drugs

1979 • 256 citations

Nifedipine, a new antihypertensive with rapid action

1977 • 246 citations

Physiological disposition of verapamil in man

1976 • 244 citations

Effects of nifedipine on myocardial perfusion and ischemic injury in dogs.

1978 • 239 citations

Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy. I. Hemodynamic effects.

1979 • 226 citations

Effect of the calcium antagonist verapamil on necrosis following temporary coronary artery occlusion in dogs.

1977 • 203 citations

Effect of drugs on conduction delay and incidence of ventricular arrhythmias induced by acute coronary occlusion in dogs

1977 • 198 citations

Prinzmetal's variant form of angina pectoris. Re-evaluation of mechanisms.

1975 • 191 citations

Trace Metals in Health and Disease

1980 • 191 citations

Inhibition of the slow inward current by nifedipine in mammalian ventricular myocardium

1977 • 189 citations

Effects of verapamil on myocardial performance in coronary disease.

1979 • 182 citations

Effect of Diltiazem on Electrical and Mechanical Activity of Isolated Cardiac Ventricular Muscle of Guinea Pig

1975 • 181 citations

The voltage- and time-dependent effects of (-)-verapamil on the slow inward current in isolated cat ventricular myocardium.

1978 • 176 citations

The metabolism of DL-[14C]verapamil in man.

1979 • 167 citations

Effect of verapamil studied by programmed electrical stimulation of the heart in patients with paroxysmal re-entrant supraventricular tachycardia.

1977 • 154 citations

Electrophysiologic and hemodynamic effects of verapamin. Correlation with plasma drug concentrations.

1978 • 150 citations

Differential effects of adenosine and nitroglycerin on the action potentials of large and small coronary arteries.

1979 • 145 citations

Gas chromatographic determination of nifedipine and one of its metabolites using electron capture detection

1979 • 140 citations

Effect of nifedipine on atrioventricular conduction as compared with verapamil. Intracardiac electrophysiological study.

1979 • 126 citations

Regional contractility. Selective depression of ischemic myocardium by verapamil.

1976 • 123 citations

On the mechanism underlying the action of D-600 on slow inward current and tension in mammalian myocardium.

1977 • 116 citations

Cardiac Purkinje fibres

1977 • 111 citations

Effects of some vasodilators on calcium translocation in intact and fractionated vascular smooth muscle

1979 • 108 citations

Reentrant ventricular arrhythmias in the late myocardial infarction period. 7. Effect of verapamil and D-600 and the role of the "slow channel".

1979 • 105 citations

Improvement of tissue perfusion with inhibitors of calcium ion influx

1980 • 99 citations

Pathogenesis and treatment of angina pectoris at rest as seen from its response to various drugs.

1978 • 97 citations

Effect of nifedipine on myocardial ischemia: Analysis of collateral flow, pulsatile heat and regional muscle shortening

1979 • 96 citations

Calciumantagonistische Therapie bei hypertroph-obstruktiver Kardiomyopathie

1976 • 94 citations

Pharmacological Preservation of the Ischemic Heart

1977 • 91 citations

Ionic basis of electrical activity in cardiac tissues

1978 • 91 citations

Effects of Calcium-Antagonistic Coronary Vasodilators on Myocardial Contractility and Membrane Potentials

1977 • 86 citations

Kinetics of inactivation and recovery of the slow inward current in the mammalian ventricular myocardium

1975 • 83 citations

Effects on atrio-ventricular conduction of calcium-antagonistic coronary vasodilators, local anaesthetics and quinidine injected into the posterior and the anterior septal artery of the atrio-ventricular node preparation of the dog

1976 • 82 citations

A Study on the Effects of Nifedipine in Hypertensive Crises and Severe Hypertension

1978 • 80 citations

The role of calcium antagonism in the therapeutic action of drugs

1979 • 74 citations

Structure-activity studies on nifedipine in isolated cardiac muscle

1979 • 72 citations

Pharmacokinetics of verapamil in man.

1979 • 70 citations

The effect of -adrenoceptor and Ca2+ antagonist drugs on the hypoxia-induced increase in resting tension

1978 • 69 citations

Verapamil and Nifedipine Inhibition of Contractions Induced by Potassium and Noradrenaline in Human Mesenteric Arteries and Veins

1979 • 69 citations

CORONARY VASODILATORY AND CARDIAC ADRENERGIC BLOCKING EFFECTS OF IPROVERATRIL

1965 • 66 citations

4-(2’-ニトロフェニル)-2,6-ジメチル-1,4-ジヒドロビリジン-3,5-ジカルボン酸ジメチルエステル(ニフェジピン),BAY-a-1040の薬理作用

1972 • 65 citations

Effects of verapamil on ventricular rhythm during acute coronary occlusion

1978 • 64 citations

Electrophysiologic Effects of Diltiazem, a New Slow Channel Inhibitor, on Canine Cardiac Fibers

1977 • 63 citations

Tetrodotoxin and Manganese Ion: Effects on Action Potential of the Frog Heart

1965 • 63 citations

The effects of nifedipine on contraction and monophasic action potential of isolated cat myocardium

1977 • 61 citations

Uncoupling cation effects on cardiac contractility and sarcolemmal Ca2+ binding

1979 • 60 citations

Investigations on the structure-activity relationships of verapamil

1978 • 59 citations

A study of compounds which inhibit vascular smooth muscle contraction

1973 • 59 citations

THERAPEUTIC TRIALS IN HAMSTER DYSTROPHY *

1979 • 51 citations

2nd International Adalat® Symposium

1975 • 48 citations

Effects of Coronary Vasodilators on Large and Small Coronary Arteries of Dogs

1977 • 45 citations

Pharmacokinetics and bioavailability of diltiazem (CRD-401) in dog.

1977 • 43 citations

Relationship of antiarrhythmic to inotropic activity and antiarrhythmic qualities of the optical isomers of verapamil

1976 • 42 citations

Does verapamil have a clinically significant antihypertensive effect?

1978 • 40 citations

"Variant" Angina Pectoris

1974 • 38 citations

Differences in the cardiac actions of the calcium antagonists verapamil and nifedipine.

1976 • 36 citations

Pharmacological evaluation of new calcium antagonists: 2-substituted 3-dimethylamino-5,6-methylenedioxyindenes.

1977 • 35 citations

Effects of nifedipine on coronary and systemic hemodynamics in the conscious dog.

1979 • 34 citations

The Effect of a Calcium‐antagonistic Drug, Nifedipine, on the Mechanical and Electrical Activity of the Isolated Rat Atrium

1975 • 33 citations

Comparison of hemodynamic effects between .BETA.-blocking agents and a new antianginal agent, diltiazem hydrochloride.

1979 • 31 citations

Haemodynamic effects of a new anti-anginal drug, diltiazem hydrochloride.

1977 • 31 citations

HYPOTENSIVE ACTION OF N-ETHOXYCARBONYL-3-MORPHOLINOSYDNONIMINE, SIN-10

1970 • 30 citations

Haemodynamic effects of supraventricular tachycardias and their alterations by electrically and verapamil induced termination

1978 • 30 citations

PANEL DISCUSSION ON THE VARIANT FORM OF ANGINA PECTORIS

1978 • 30 citations

Effect of diazoxide, verapamil and compound D600 on isoproterenol and calcium-mediated dose-response relationships in isolated rabbit atrium

1977 • 30 citations

Sites of action and active forms of lidocaine and some derivatives on cardiac Purkinje fibers.

1978 • 28 citations

Reversible inhibition of potassium contractures by optical isomers of verapamil and D 600 on slow muscle fibres of the frog

1976 • 27 citations

Hemodynamic effects caused by i.v. administration of verapamil in healthy subjects.

1976 • 24 citations

The Effect of the Calcium-Antagonistic Drug Nifedipine on Coronary and Left Ventricular Dynamics in Patients with Coronary Heart Disease

1980 • 23 citations

Hemodynamic Studies on Adalat in Healthy Volunteers and in Patients

1975 • 23 citations

Suppression of Repeatedly Occurring Ventricular Fibrillation with Nifedipine in Variant Form of Angina Pectoris

1977 • 20 citations

Investigations on the Metabolism and Protein Binding of Nifedipine

1975 • 20 citations

Application of Calcium Antagonists in Patients with Prinzmetal Angina Pectoris

1980 • 12 citations

The Effect of Verapamil on the Contractility of Smooth Muscle and on Excitation-Secretion Coupling in Adrenergic Nerve Terminals

1971 • 12 citations

On the action of nifedipine under conditions of variable stimulation patterns and [Ca2+]0 in guinea-pig atrium

1976 • 11 citations

1st International Nifedipine [Adalat] Symposium : new therapy of ischemic heart disease

1975 • 7 citations

Nifedipine in the Treatment of Life Threatening Prinzmetal Angina

1979 • 7 citations

Effects of D 600 and papaverine on the inotropic response to isoprenaline on left guinea-pig atria under the graded influence of changes of frequency and temperature.

1977 • 2 citations

[The effect of nifedipine on the pulmonary artery pressure in patients with coronary heart disease (author's transl)].

1978 • 1 citations