Protein-C: biochemistry, physiology, and clinical implications

Deficiency of protein C in congenital thrombotic disease.

1981 • 1,260 citations

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 831 citations

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

1982 • 709 citations

A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization.

1976 • 634 citations

Human Plasma Protein C

1979 • 511 citations

Preparation and properties of bovine factor VIII (antihemophilic factor)

1980 • 504 citations

Anticoagulant properties of bovine plasma protein C following activation by thrombin

1977 • 495 citations

Regulation of activated protein C by a new protein. A possible function for bovine protein S.

1980 • 460 citations

Regulation of activated protein C by protein S. The role of phospholipid in factor Va inactivation.

1981 • 397 citations

Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme

1982 • 385 citations

Inactivation of human coagulation factor V by activated protein C.

1983 • 374 citations

Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 330 citations

Generation of fibrinolytic activity by infusion of activated protein C into dogs.

1981 • 303 citations

Protein C Deficiency in a Dutch Family with Thrombotic Disease

1982 • 287 citations

Protein C inhibitor. Purification from human plasma and characterization.

1983 • 238 citations

Acquired Vitamin K-Dependent Carboxylation Deficiency in Liver Disease

1981 • 224 citations

DEFICIENCIES OF PROTEIN C, AN INHIBITOR OF BLOOD COAGULATION

1982 • 224 citations

Deficiency of protein C inhibitor in combined factor V/VIII deficiency disease.

1980 • 207 citations

Clearance of Thrombin from Circulation in Rabbits by High-affinity Binding Sites on Endothelium

1980 • 204 citations

Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C.

1983 • 202 citations

Protein C, an antithrombotic protein, is reduced in hospitalized patients with intravascular coagulation

1982 • 193 citations

Amino acid sequence of the light chain of bovine protein C.

1982 • 162 citations

Studies of the capacity of factor Xa to protect factor Va from inactivation by activated protein C.

1982 • 141 citations

beta-Hydroxyaspartic acid in vitamin K-dependent protein C.

1983 • 138 citations

Determination of functional levels of protein C, an antithrombotic protein, using thrombin-thrombomodulin complex

1984 • 137 citations

Activation of Purified Prothrombin to Autoprothrombin I or Autoprothrombin II (Platelet Cofactor II or Autoprothrombin II-A)

1961 • 131 citations

Activation of Protein C In Vivo

1982 • 128 citations

Use of endothelium cultured on microcarriers as a model for the microcirculation.

1982 • 98 citations

Activated protein C inhibits platelet prothrombin-converting activity

1979 • 95 citations

Interaction of calcium with bovine plasma protein C

1981 • 88 citations

Evidence of normal functional levels of activated protein C inhibitor in combined Factor V/VIII deficiency disease.

1982 • 77 citations

Autoprothrombin II-A: Thrombin removal and mechanism of induction of fibrinolysis

1973 • 65 citations

Inhibitory Effect of Activated Protein C on Activation of Prothrombin by Platelet-Bound Factor Xa

1980 • 63 citations

Human coagulation factor Va is a cofactor for the activation of protein C.

1983 • 53 citations

Quantitation of coagulant antigens and inhibition of activated protein C in combined factor V VIII deficiency

1982 • 32 citations

Isolation and Characterization of an in vivo Thrombin‐Induced Anticoagulant Activity

1974 • 10 citations

Protein C, a Regulator of Prothrombin Activation

1982 • 5 citations