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IGF-1 signaling reduces neuro-inflammatory response and sensitivity of neurons to MPTP

Data up to Jan 2025

Published2008
Citations39
References56

Total Citations Per Year

Abstract

References (56)

Estimation of nuclear population from microtome sections

1946 • 4,378 citations

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

2006 • 3,752 citations

Some new, simple and efficient stereological methods and their use in pathological research and diagnosis

1988 • 2,948 citations

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

2006 • 2,130 citations

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

2002 • 2,057 citations

Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

2006 • 1,997 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

2001 • 1,210 citations

Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

2002 • 1,171 citations

Unbiased stereological estimation of the number of neurons in the human hippocampus

1990 • 1,146 citations

Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta.

1993 • 789 citations

Production of tumor necrosis factor-alpha by microglia and astrocytes in culture

1989 • 626 citations

Production of superoxide anions by a CNS macrophage, the microglia

1987 • 619 citations

Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1995 • 608 citations

The Insulin-Like Growth Factor System and Its Pleiotropic Functions in Brain

2005 • 468 citations

Role of Nitric Oxide in Inflammation‐Mediated Neurodegeneration

2002 • 424 citations

Replicating Huntington's disease phenotype in experimental animals

1999 • 410 citations

Inflammatory Process in Parkinsons Disease: Role for Cytokines

2005 • 406 citations

The Inflammatory Reaction Following 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Intoxication in Mouse

1999 • 372 citations

Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: Implications for Parkinson's disease

2002 • 366 citations

Activation of microglia by human neuromelanin is NF‐κB‐dependent and involves p38 mitogen‐activated protein kinase: implications for Parkinson's disease

2003 • 303 citations

Neuroinflammatory processes in Parkinson's disease

2005 • 292 citations

Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics

2003 • 249 citations

Enriched Environment Confers Resistance to 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine and Cocaine: Involvement of Dopamine Transporter and Trophic Factors

2003 • 209 citations

Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3‐nitroproprionic acid in SK‐N‐SH human neuroblastoma cells

2001 • 203 citations

Basic FGF, NGF, and IGFs Protect Hippocampal and Cortical Neurons against Iron-Induced Degeneration

1993 • 199 citations

Activation of murine microglial cell lines by lipopolysaccharide and interferon‐γ causes NO‐mediated decreases in mitochondrial and cellular function

2001 • 191 citations

RETRACTED: A new mechanism of neurodegeneration: A proinflammatory cytokine inhibits receptor signaling by a survival peptide

1999 • 190 citations

The mitogen activated protein kinase signal transduction pathway: From the cell surface to the nucleus

1994 • 187 citations

Protective effect of melatonin on 3‐nitropropionic acid‐induced oxidative stress in synaptosomes in an animal model of Huntington's disease

2004 • 137 citations

Insulin and IGF-I Receptors Signaling in Protection from Apoptosis

1999 • 133 citations

Protective effect of insulin-like-growth-factor-1 against dopamine-induced neurotoxicity in human and rodent neuronal cultures: possible implications for Parkinson’s disease

2001 • 115 citations

Implication of the Phosphatidylinositol-3 Kinase/Protein Kinase B Signaling Pathway in the Neuroprotective Effect of Estradiol in the Striatum of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mice

2006 • 106 citations

Experimental IGF-I Receptor Deficiency Generates a Sexually Dimorphic Pattern of Organ-Specific Growth Deficits in Mice, Affecting Fat Tissue in Particular

2001 • 98 citations

Role of TNF-α Receptors in Mice Intoxicated with the Parkinsonian Toxin MPTP

2002 • 88 citations

Neuroglial responses to the dopaminergic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse striatum

1995 • 80 citations

Effects of insulin-like growth factor-I on cytokine-induced sickness behavior in mice

2005 • 79 citations

Levodopa‐induced dyskinesia in MPTP‐treated macaques is not dependent on the extent and pattern of nigrostrial lesioning

2005 • 79 citations

Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies

2003 • 77 citations

Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice

2000 • 74 citations

Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine model of Parkinson’s disease

2007 • 69 citations

Mechanisms of MPTP toxicity and their implications for therapy of Parkinson's disease.

2005 • 69 citations

IGF-I receptor signalling: lessons from the somatotroph.

1996 • 68 citations

Time-course of the expression of inflammatory cytokines and matrix metalloproteinases in the striatum and mesencephalon of mice injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a dopaminergic neurotoxin

2003 • 66 citations

Tumor Necrosis Factor‐α Induces Neuronal Death by Silencing Survival Signals Generated by the Type I Insulin‐Like Growth Factor Receptor

2000 • 66 citations

The neurotoxicant MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) increases glial fibrillary acidic protein and decreases dopamine levels of the mouse striatum: Evidence for glial response to injury

1988 • 57 citations

TNFα-induced sickness behavior in mice with functional 55 kD TNF receptors is blocked by central IGF-I

2007 • 57 citations

Influence of chemical and ischemic preconditioning on cytokine expression after focal brain ischemia

2004 • 50 citations

Pattern of levodopa‐induced striatal changes is different in normal and MPTP‐lesioned mice

2003 • 45 citations

Rescue of TNF?-inhibited neuronal cells by IGF-1 involves Akt and c-Jun N-terminal kinases

2004 • 45 citations

Insulin‐like growth factor‐I ameliorates demyelination induced by tumor necrosis factor‐α in transgenic mice

2007 • 40 citations

Tumor necrosis factor-? regulation of insulin-like growth factor-I, type 1 IGF receptor, and IGF binding protein expression in cerebellum of transgenic mice

2002 • 38 citations

Simultaneous Detection of NO and ROS by ESR in Biological Systems

2005 • 32 citations

Chinonin, a novel drug against cardiomyocyte apoptosis induced by hypoxia and reoxygenation

2000 • 27 citations

Stereological evaluation of substantia nigra cell number in normal and hemispherectomized monkeys

1999 • 23 citations

The IGF/IGF-1 receptor signaling pathway as a potential target for cancer therapy

1999 • 17 citations

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